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作者：信莲 来源：中国日报网 发布时间：2011-9-25 1 ~+ j0 _; K5 _ T
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这种病毒名为腺相关病毒2型（AAV2）。（来源：英国媒体）
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" Z) I' ~ _6 ?你相信有一种病毒能在7天内杀死乳腺上的癌细胞吗？美国科学家找到了一种神奇的病毒，它可能为乳腺癌的治疗带来新方法。: _: }7 e$ I" [0 A6 D3 _4 L: x
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综合国外媒体9月23日报道，这种病毒名为腺相关病毒2型（AAV2），约有80%的人携带这种病毒，它会对人体产生影响，但是不会致病。宾夕法尼亚州州立医学院的研究人员2005年发现，该病毒可导致宫颈癌患者的癌变细胞死亡。随后他们针对不同阶段乳腺癌病变细胞进行试验，在使用AAV2对付癌变细胞后，所有癌变细胞在7天内都消失了。$ f" o& J b, R7 P
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微生物学与免疫学方向的助理研究员萨米纳·阿拉姆指出：“如果可以判定哪些病毒基因发挥了作用，我们就可以将这些基因引入治疗方法中，如果我们能够确定AAV2触动了哪些路径，就可以研制出启动那些路径的药物，或者可以只用该种病毒本身来治病。”2 g0 \4 |* b- `, b7 X3 l1 ]
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美国疾病控制中心人员表示，在美国女性中，乳腺癌是最为常见的一种癌症，造成的死亡人数也较多。有关专家认为，由于乳腺癌患者发现自己患癌时所处阶段不同，所以治疗方法也不同。“在治疗乳腺癌患者时，你不能采用同一种方法，”微生物学与免疫学教授克雷格·迈耶斯说。2 H6 p4 ]+ x6 V- j% w
: ?1 p/ |! E* k3 W' o7 P研究人员通过一项正在进行的研究发现，AAV2还可以杀死身体其他部位的癌变细胞，如前列腺癌、鳞状细胞癌及黑素瘤等。目前的试验对象都是小老鼠，不久后，研究人员将把近阶段所取得的成果进行刊发。
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2 C# f, I( d' K3 R4 Q7 q% S.....Virus that does not cause disease kills human breast cancer cells in lab/ T, T. O% Z U, C
By ANI | ANI – Fri, Sep 23, 2011.........Washington, Sept 23 (ANI): A study has found that a non disease causing virus kills human breast cancer cells in the laboratory, creating opportunities for potential new cancer therapies.2 s& r( A& h8 q0 u, K
; B; ~( x2 H p: }Penn State College of Medicine researchers, who tested the virus on three different breast cancer types that represent the multiple stages of breast cancer development, made the findings.; D, s' \- _3 l* Z! c/ U: H) M0 ?) H
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Adeno-associated virus type 2 (AAV2) is a virus that regularly infects humans but causes no disease. Past studies by the same researchers show that it promotes tumour cell death in cervical cancer cells infected with human papillomavirus. 7 n" }8 d3 X! L% f3 } e
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Researchers used an unaltered, naturally occurring version of AAV2 on human breast cancer cells.
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"Breast cancer is the most prevalent cancer in the world and is the leading cause of cancer-related death in women. It is also complex to treat," said Samina Alam, Ph.D., research associate in microbiology and immunology.
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Craig Meyers, Ph.D., professor of microbiology and immunology, said breast cancer is problematic to treat because of its multiple stages.# h% i3 I0 F! d
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"Because it has multiple stages, you can't treat all the women the same. Currently, treatment of breast cancer is dependent on multiple factors such as hormone-dependency, invasiveness and metastases, drug resistance and potential toxicities," Meyers said. ) K& n! z/ C' Z x% B9 M
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"Our study shows that AAV2, as a single entity, targets all different grades of breast cancer," he stated.
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In tissue culture dishes in the laboratory, 100 percent of the cancer cells are destroyed by the virus within seven days, with the majority of the cell death proteins activated on the fifth day. 9 x; {* E! G1 ^+ n
* q2 V4 E& @8 x3 I. HIn another study, a fourth breast cancer derived cell line, which is the most aggressive, required three weeks to undergo cell death.
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Research needs to be completed to learn how AAV2 is killing cancer cells and which of its proteins are activating the death pathways. (ANI)3 r$ l8 J- m6 E1 F1 {+ }: _1 Q
: l! X# R' n& z1 v" rhttp://in.news.yahoo.com/virus-d ... east-113809461.html
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发表于 2011-9-25 12:52
发表于 2011-9-25 19:55
