|
  
- 积分
- 553
- 威望
- 553
- 包包
- 2483
|
主题：NIH（美国国立卫生研究院）评审委员会批准增加干细胞系——2010年12月10日5 t @& y5 A7 A5 [4 O$ c1 U
" Y7 q( I2 O2 g& L
说明：新闻来源nature.com 由干细胞之家新闻小组成员 飞翔的十字架 翻译
8 `" ^; Z& y$ H( K6 X' W( g' l0 V' c6 n/ b% r9 G* z
翻译内容：
) M- }2 F" R1 e; J* Y$ d; V* e& X/ w& Z/ t7 Z6 M: o* `
NIH的主任顾问小组已经在12月9日提议增加4个hESC（人的胚胎干细胞）细胞系用于由美国政府资助的研究项目。如果代理主任Francis Collins 在接下来数天批准这个提案，那么可用于资助项目的细胞系数将由现在的82变成86。新增加的细胞系中的两个来自印度班加罗尔的进行高级科学研究的Jawaharlal Nehr中心，另两个来自瑞典的生物技术公司Cellartis。
' R( ?) ?7 N4 G9 S1 G/ E- j
. C6 u G# V0 G! ~2 e但是委员会对于另外几种细胞系的讨论（从09年12月开始，其中几种已经被否决）显示其审批流程任然十分紊乱。草率马虎的一致同意流程将芝加哥Children's Memorial Hospital 递交的3个细胞系拒之门外。
~- G8 d+ N- r/ }6 J( V% F" C还有一个例子，由于一个可翻译为“样本”或“胚胎”的中文翻译问题，委员会搁置了对由广州医学院提供的6个细胞系的讨论，直到有华裔专家的参与。
( L3 o9 a& I0 w( L. {! n+ f8 J
; i0 ~; X1 G% l; u0 Z在一场力求阻止美国政府资助胚胎干细胞研究诉讼的关键辩论数天之后，事情变得明朗，至少有一个妇产科诊所提出申请，撤出涉及到使来源于剩余胚胎的干细胞系得到政府资助的一项工程。" L& ?- u. m% T% `6 [" G6 L
6 `! s( c; Y/ \3 _6 a8 C- I" e
消息显示，根据Texas Health Science Center大学的干细胞科学家Rick Wetsel 在10月26日给NIH的email，自从8月州地方法院签发初步禁令，暂时停止联邦资助的研究，作为胚胎来源的试管受精中心就中断了与他的合作交流。Wetsel 正在搜寻相关文件同时想得到NIH对于其实用细胞系的许可或支持。
# O$ k \7 A% u* h# F4 v3 r0 g7 l/ x4 [" ]
Wetsel的邮件：（略）( u3 E9 x& f- o' H# S U7 |; F, T
! U& w: c3 S3 B. k) l
事务委员会对于Texas 州法院的决定提交了报告，但最终被咨询委员会以其他理由驳回，包括明显的草率同意流程。
' v$ Q5 e2 l ?/ s9 K* v* h" i( z3 K. q/ [. g0 ~
Story Landis，NIH中神经疾病与中方国立研究院主任，也是审批流程的官方监督员，他注意到委员会投票之后反馈到委员会的意见正在下降。Story Landis 说：“我们已经着手处理那些积压的工作（从George W. Bush时代开始累积）。有这样的可能性，那些对各个干细胞系进行审核的委员会工作小组成员能够商业领域抽身，除了一些外国的捐赠。”
. ?: l, M. F9 k" V5 I" K: r7 F' n1 H8 s K" i, R
原文及连接：; M7 z5 {6 B" a. X1 I- ^7 ]# C
) y# l6 O5 `. F0 M4 H' ]' A8 \" zhttp://blogs.nature.com/news/thegreatbeyond/2010/12/nih_panel_approves_9_new_stem.html
" U0 K4 O! U% @+ X$ X
7 i6 c" N4 _! i( cA key advisory panel to the National Institutes of Health (NIH) director has recommended that four additional human embryonic stem cell lines be added to those eligible for US funding. If agency director Francis Collins concurs in coming days with the advice offered on 9 December by his advisory committee, as is widely expected, the number of fundable lines will rise to 86 from the current 82. Two of the new lines come from the Jawaharlal Nehru Centre for Advanced Scientific Research in Bangalore, India and two from Swedish biotech company Cellartis.
- n0 y' {* E9 D' d. l
: p4 L3 p2 _7 E- bBut the committee's discussion of several other lines, some of which it rejected, revealed that the approval process that began one year ago this month can still be a tangled web. Sloppy consent procedures torpedoed three lines submitted by the Children's Memorial Hospital in Chicago. (See, for example, pages 16,18 and 22 at this link. The informed consent forms were used by the fertility clinic where couples donated the embryos -- the Midwest Fertility Center in Downer's Grove, Illinois.) $ U# |9 j$ s* d! {
- f, u6 G: l6 U W+ F! NAnd in one case, problems with the translation of a single Chinese word -- that can be translated as both "specimen' and "embryo"-- led to the tabling, until expert native-Chinese speakers can weigh in, of a decision on six lines from Guangzhou Medical College in China. (For the full plethora of Guangzhou-related documents, see here and here.)' I6 i# p6 M% J! [# W1 P* d/ }
, h, e" Q ^1 W: f: A/ ? ]
And, days after key oral arguments in a lawsuit seeking to block US funding for human embryonic stem cell research, it became clear from another application that at least one US infertility clinic has pulled back from participating in a process which would allow stem cell lines derived from its leftover embryos to receive US funding.
2 z. h4 x6 J+ X; W" P
( [. ` b6 B+ X4 u Y% J+ \6 E) [$ @1 E9 q& P0 M9 z Z4 E) e
According to an October 26 email to NIH from stem cell scientist Rick Wetsel at the University of Texas Health Science Center at Houston, which owns the relevant lines, the IVF clinic that was the source of the embryos from which the lines were derived has stopped communicating with him since a preliminary injunction was issued by a US district court in August, temporarily blocking federal funding for the research. Wetsel was seeking documentation from the clinic as part of the effort to win NIH approval for the lines.
3 g- R6 L, C9 S: m7 \8 q/ y( r% ^" T& [4 B7 }
Wetsel wrote:" S- m% C; Y# o3 k
' n6 V$ ~* `. `: V"Before the injunction was filed, [name redacted] had said that she would retrieve the clinical consents, but that they were offsite and it would take her a couple of weeks," Wetsel writes to Ellen Gadbois, the key NIH staffer facilitating the approval process. "However, once the injunction was filed, [name redacted ]will no longer answer my emails or phone calls. I am assuming that she is afraid that the fertiliy clinics involved in the approved NIH hESC lines may be sued if the federal judges agree in the end with [the] injunction. She was always very responsive to our questions prior to the injunction....Of course, this has really upset our financial donor, who donated a considerable amount of money in the hope that someday UT would have their own early passage hESCs for federally funded research.". M7 F7 h4 |& r5 W" j& W( z
6 H$ N D0 H2 I7 n( H+ d
The report of the committee's working group on the Texas submission can be found here. In the end, it was voted down by the advisory committee for other reasons, including the sloppy consent procedures visibile, for instance, on pages 11, 12 and 14 here.8 s! i* `* L9 F) h2 b" m' t
) U7 b/ Q* O; L
Story Landis, the director of NIH's National Institute of Neurological Diseases and Stroke, who is the agency's top official overseeing the approval process, noted after the committee's votes were taken that the volume of submissions coming into the committee is falling off. "I think we have caught up with the backlog," that accumulated during the George W. Bush era, Landis said. "There’s the possibility that [the committee working group assigned to stem cell line reviews] could go out of business, except for foreign donations.'
0 }* [2 n6 |0 @8 E, L) H0 [! Z* A# _+ B& d7 ]
注明：第一段是新闻主体吧，后面的忧郁对背景不是很熟悉，只凭字面翻译，请大家指正: P) F" v$ W- k7 X
+ b% s! C- z$ q, o6 h6 F# h
. \- y/ g+ @$ C$ z: P: W# p! e# \
|
-
总评分: 威望 + 20
包包 + 100
查看全部评分
|
发表于 2010-12-12 17:04
