|
- 积分
- 2172
- 威望
- 2172
- 包包
- 6551
|
Dynamic regulation of mitochondrial function in preimplantation embryos and embryonic stem cells
$ i4 p' H+ `+ p' \6 S4 o0 |0 H% D: L4 u' U) S. C9 D
Alexandra Harveya, 1, Tiffini Gibsona, c, Thomas Lonergand and Carol Brennera, b,( e9 O' P, h }% w! H8 B: K, B9 J
a Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, United States
# H0 J( R4 O1 z7 M1 M. Kb Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, 48201, United States- ^1 T3 O. v/ S0 Q
c Carribbean Primate Research Center, Sebana Seca, Puerto Rico
' \- q; T8 E2 g$ Yd Department of Biological and Environmental Sciences, Western Connecticut State University, Danbury, CT 06810, United States! {' l7 t7 M% \! c8 \5 o
Received 11 May 2010; revised 6 December 2010; accepted 9 December 2010. Available online 17 December 2010
( ?( I: P9 [6 F) v- x6 y/ B0 A
, V' G+ E# S4 o' N原文来源自
) C- W* K; i/ c! Z5 U0 E/ s5 mhttp://www.sciencedirect.com/sci ... searchtype=a#cr0005
3 c- z8 `7 _' b由干细胞之家新闻小组成员Hyde翻译（转帖请注明）
5 i% ]+ }+ p# h% Y, T _摘要：; J5 s4 [; w/ v% ` h, s
线粒体的功能与生物合成和生物动力学相关。大量的研究表明这些细胞器在胚胎移植前和ESCs中的重要性，但是在很多方面我们知之甚少，比如对于它们如何通过调节形态、活动应对微环境的直接变化，以及扰乱这些过程是否会对移植和分化造成重大的影响。我们从两个方向总结了现有的一些文献，细胞核和线粒体的交叉关系，通过调节线粒体生物合成、形态、活动来进行功能调节的过程中存在的动力学过程,着重于胚胎和ESCs。6 [; I/ j/ k0 {7 \9 L, d
8 {+ Y5 L6 o' P( n
Abstract$ f+ _" I; h& t% u6 r! m4 U8 t6 \
Mitochondrial function is dependent upon regulation of biogenesis and dynamics. A number of studies have documented the importance of these organelles in both preimplantation embryos and embryonic stem cells (ESCs), however it remains unclear how mitochondria respond to their immediate microenvironment through modulation of morphology and movement, or whether perturbations in these processes will have a significant impact following differentiation/implantation. Here we review existing literature on two key aspects of nuclear–mitochondrial cross-talk and the dynamic processes involved in mediating mitochondrial function through regulation of mitochondrial biogenesis, morphology and movement, with particular emphasis on embryos and ESCs.7 b8 S1 V7 q* J$ R4 ]
Keywords: Mitochondria; Preimplantation embryo; Embryonic stem cell; Biogenesis; Dynamics; Development
+ C2 P" x/ j( Y4 f S! X) B/ g& [& \; G% s4 o
个人翻译，理解不准确的语句还望大家积极指出。9 k, g5 p& e1 x. n. x7 }
|
-
总评分: 威望 + 20
包包 + 100
查看全部评分
|
发表于 2010-12-27 14:56
