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'Cell explosions' can trigger instant cancers " _1 r7 { Q. x# t0 j
January 8th, 2011 % J! u8 i1 k7 y3 V6 t2 j! U" H
IANS http://www.deccanchronicle.com/g ... instant-cancers-193
' T9 D* x) q) B! A+ i: ?+ ]0 SBritish scientists have decoded the mystery of why 'instant cancers' seemingly appear out of nowhere.) H1 I6 T+ t0 G: j" \! I
The finding from the Wellcome Trust Sanger Institute in the UK contradicts the long-held theory that thousands of mutations over a lifetime cause cancer. 5 S/ h: C6 O A
It also helps explain why some people are diagnosed with cancer only months after x-rays or other tests fail to detect traces of the disease, the journal Cell reports.
7 y' ]6 E; U! E: A RThe discovery was based on the genetic flaws in 750 tumours. In most cases, the damage to chromosomes upheld the conventional picture of cancer creeping up over the years, according to the Daily Mail.
; u }4 Z; B: W' _' a% A+ ~& tBut at least one tumour in 40 didn't fit the pattern. Instead, the damage appeared to have been done almost overnight.0 U/ o& e8 }9 M
Researcher Peter Campbell said: "The results astounded us. It seems that in a single cell, in a single event, one or more of the chromosomes explode - literally into hundreds of fragments." u: p! b: i# ?
If the cell then botches the repair, stitching the fragments back together in a 'higgledy piggledy' fashion, the damage to its genome, or cache of DNA, leaves it ripe for the rapid development of cancer.' x/ h! |: p' S# @) `% L
Campbell said: "They attempt to reconstruct the unreconstructable and they wind up with a disastrous genome that shortens the road to cancer."
2 R s2 A( `# J6 i9 g1 F3 O# n$ h# kThe phenomenon is particularly common in bone cancers, where the distinct pattern of damage is seen in up to one in four cases. But it is thought to be to blame for more than one in 40 of all cases of the disease.3 L' A+ a% k/ S) h4 C, u
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p* s3 n. b* [# K, r) q- EThe Mystery of "Instant Cancers" 4 r: T1 {5 c' `9 X& f9 R
#0, by emeline, 07 January 2011 09:52 AM http://tinfoilpalace.eamped.com/ ... of-instant-cancers/( Y& L. E* A% E1 r: u0 l7 t# U
Why some cancers seems to develop in an instant - cells can explode wreaking havoc in DNA7 v, v8 P8 l M) c: J4 H
The mystery of 'instant cancers' - tumours that seem to appear out of nowhere - has been solved by British scientists.
, o6 X( x- @3 l( ], V) d) g* f! mIn some cases, a single apocalyptic ‘explosion’ in a cell can cause as much damage to the DNA as decades of hard living.
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1 w* b. v: K k: ?( x! _( b$ aA model of a DNA Molecule. Scientists have found one in 40 cancers could develop rapidly after an unexpected cell explosion causes DNA damage# n5 o! [; z; |3 {- l
The finding, from the Wellcome Trust Sanger Institute near Cambridge, contradicts the long-held theory that cancer is the consequence of hundreds, or thousands, of mutations that build up over a person’s lifetime.
Z6 m' ~# `0 |! YIt suggests that no matter how healthy some people try to be, fates is conspiring against them. And it helps explain why some people are diagnosed with cancer only months after x-rays or other tests found no trace of the disease.5 L0 E" f" \% j; f L
The discovery was made from the study of the genetic flaws in 750 tumours.! X. B, B% u6 z6 k
In most cases, the damage seen to the chromosomes fitted with the conventional picture of cancer creeping up over many years.9 D& f3 n% C @
But at least one tumour in 40 didn’t fit the standard pattern, the journal Cell reports.
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; u) e, S7 E4 VScientists ‘Crack’ Mystery behind Instant Cancers 4 D- t* V7 x4 W5 @. G4 W
Submitted by Davell Wilkins on Fri, 01/07/2011 - 08:57 http://topnews.us/content/232009 ... ind-instant-cancers
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Claiming to have cracked the suspense shrouding the occurrence of tumours that appear from nowhere, British scientists say the so-called 'instant cancers' may be due to an abrupt ‘cell explosion’ called DNA damage. This sudden cell explosion could be a cause of cancer in one in 40 cases.% Y5 _7 c& i! o9 ~- w
Done by the Wellcome Trust Sanger Institute near Cambridge, the discovery took into account the study of the genetic flaws in as many as 750 tumours.
9 q, E+ ]7 w2 a0 s; o/ XAlso, this discovery contradicts the prevailing theory that the lethal disease cancer resulted out of hundreds, or even thousands, of cell alternations that take place in a human body.
$ f& w, A- Y5 h: M5 N. o0 ~According to the scientists, one in 40 cancer cases could be a result of unexpected cell explosion, which subsequently rapidly damages the DNA. And in a few cases, the scientists say, the damage caused to the DNA by a single apocalyptic ‘explosion’ in a cell was equivalent to about as much as 10 years of hard living.
0 \& @7 y5 I- l2 F“It seems that in a single cell in a single event, one or more chromosomes basically explode - literally into hundreds of fragments”, said study leader Dr. Peter Campbell, from the Wellcome Trust Sanger Institute in Hinxton.7 D1 v4 C2 T# [0 @
And in some cases, DNA repair machinery tries to attach the chromosomes back together but gets it disastrously wrong, says Dr. Campbell, adding out of the hundreds of mutations that result, several promote the development of cancer.
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发表于 2011-1-8 23:57
发表于 2011-1-9 00:24
