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回复 a2782953 的帖子8 y5 I4 c( e! K3 g" z
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"Shinya Yamanaka says the Myc genes may hold the key to other aspects of reprogramming."
. c) `/ f8 w2 z# b0 j+ z"Myc family genes can promote reprogramming independent of their ability to make tumors."3 v/ R: H" ]/ ^6 C
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"...Yamanaka warns, merely eliminating Myc or integrating factors does not guarantee the0 v1 T& ?/ T$ f) F
safety of iPS cells."
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O+ }6 d4 e# r. E"Some iPS cell–derived tumors could be caused by reactivating the gene encoding Myc, others by residual undifferentiated cells that resist cues for differentiation, a property that correlates with the tissue from which the iPS cells were originally derived3. And, according to Yamanaka, there may be other causes..."
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总体来说，即便去掉外源性Myc，iPS的成瘤风险仍然无法排除。听起来还是比较不那么乐观。 |
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发表于 2011-3-10 22:40
发表于 2011-3-11 10:08
