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"Without knowing more clinical detail, there's little I can say. In more general terms ... I remain concerned about the long-term safety of unpurified grafts of embryonic stem cell derivatives. Time will tell."--Steve Goldman, chairman of the department of neurology at the University of Rochester in New York.
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"I thought maybe caspases could also induce iPS cells instead of the four transcriptional factors that Yamanaka used. If that was true, it would be very exciting...It is now becoming clear that caspases don't just kill, but they can change the cell's fate. They could be a mediator of epigenetic changes in multi-cellular organisms."--University of Colorado Cancer Center researcher Chuan-Yuan Li.2 q9 ]) _( G6 Q. P* a
, z; e; W% y4 Z3 o"There is no doubt that this is the dawn of the stem cell age. This is the first time that the really most potent stem cells have been allowed to be used in man. We can only do so much to animals, now's the time to see if they really work in man...This pivotal clinical trial is a major morale boost for scientists, clinicians and most of all patients by finally commencing the transformation of stem cells from a scientific curiosity into advanced healthcare."--Chris Mason, a professor of regenerative medicine at the University College, London.
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* a$ L$ a6 ~9 b"We've known from laboratory studies that the potential of human embryonic stem cells is enormous. But until you show you can actually translate the laboratory findings into the clinics, you are really speculating that they can be used therapeutically."--Dr Stephen Duncan, the director of the regenerative medicine program at the Medical College of Wisconsin.
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"If it works, there will hopefully be far fewer critics of research on human embryonic stem cells, especially in the USA.If it does not, the critics will no doubt be rejoicing, but they will be foolish to do so. Other trials will follow soon, for a range of clinical problems -- and even if just one works well, it will all be worthwhile."--Robin Lovell Badge of the National Institute of Medical Research at Britain's Medical Research Council. \9 G0 x; d1 `, _
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"This is very exciting news, however, it is very important to appreciate that the objective of trials at this stage is to confirm first of all that no harm is done to patients, rather than to look for benefits. Once that has been confirmed then the focus moves on to development and assessment of the new treatment."--Sir Ian Wilmut, director of the MRC Centre for Regenerative Medicine at Edinburgh University.' Z$ H( |" m3 d, o
, X9 w2 R6 m5 x% g4 d( t9 s"This is the dawn of a new era in medical therapeutics. We are leaving behind the days of using pills to treat symptoms, and entering a new era where we're using living human cells to permanently restore organ function damaged by a disease or an injury...We can only admit one patient a month for the first few patients, so it will take about six months to a year before we have enough rigorous data to be able to say something about safety and any possible efficacy that we detect"--Tom O'Karma, president and CEO of Geron Corporation.
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"This is a huge milestone for the field, marking the first time a product of a human [embryonic stem cell] has been transplanted into a patient. It has taken years and reams of regulatory documentation to get to this milestone. I hope the trial proceeds safely and that this represents just the first of many trials to follow...This is only the first attempt and we should anticipate lots of failures before we learn how to deliver cells safely and effectively," Daley said. "I wish this brave patient well."--Dr. George Daley, director of Stem Cell Transplantation at Children's Hospital Boston and the Dana-Farber Cancer Institute in Boston.
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$ [ l9 y' j2 L0 y/ K: h1 P$ B"This is an important milestone. Nonetheless, we must bear in mind that there is a real concern about safety, since these cells have not been used clinically before. If the cells do prove to be safe in this trial, that would represent another milestone that would make it easier to perform future trials involving cells obtained from [human embryonic stem] cells. If they observe adverse events in the patients, such as tumor formation, this could really set the field back."--Sean Morrison, director of the Center for Stem Cell Biology at the University of Michigan in Ann Arbor.- J. S6 P& q2 W% x: J1 y( j) o/ o
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"It is remarkable that only 12 years after the discovery of human embryonic stem cells, regenerative medicine therapies based this technology are entering clinical trial. Much of the preliminary data on the safety and efficacy of this treatment is of course proprietary, so it is difficult to assess its likelihood of success, but the entire stem cell field will be watching the progress of this trial very carefully."--Martin Pera, professor and foundation director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.
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0 O5 o+ V& B# D& W9 K- c; F) y5 g"There is great hope that these revolutionary treatments will be effective, not only in spinal cord injury but also in other diseases, including Parkinson's disease, ALS, forms of heart disease, diabetes and more. However, it is only with such careful clinical trials that we can accurately determine if embryonic stem cell therapies truly can treat these major diseases without excessive risks."--Dr. Timothy Kamp, co-director of the Stem Cell and Regenerative Medicine Center at the University of Wisconsin Medical School in Madison. p! V; k, P! M$ R1 l+ f8 n
: f2 c3 n0 w9 T, L4 o"Let me give you two scenarios. First the wildly optimistic: that thirty years from now we will look back on today as one of the most significant in the history of modern medicine; the day everything began to change. The second is pessimistic: that in the near future we will see that embryonic stem cells did not live up to the hype, dashing the hopes of patients."--Fergus Walsh of BBC news.* d, K# r) S+ K& G
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# ]. E+ G4 I; S( g3 PThis issue:
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- g% F! |- n4 U* E3 u6 QVideo news:9 x1 {0 }% l1 j$ x* R
More People Injecting Stem Cells into their Hearts0 j+ h# c$ o9 `/ ]% v1 S8 Y
http://www.redorbit.com/news/vid ... their_hearts/25723/ |
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发表于 2010-10-19 19:52
