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标题: Citation Advantage of Open Access Articles [打印本页]

作者: 春天的风筝    时间: 2009-4-23 09:05     标题: Citation Advantage of Open Access Articles

1 Centre for Global eHealth Innovation, University Health Network; and Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
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. W& E9 U+ {$ o& s  yOpen access (OA) to the research literature has the potential to accelerate recognition and dissemination of research findings, but its actual effects are controversial. This was a longitudinal bibliometric analysis of a cohort of OA and non-OA articles published between June 8, 2004, and December 20, 2004, in the same journal (PNAS: Proceedings of the National Academy of Sciences). Article characteristics were extracted, and citation data were compared between the two groups at three different points in time: at ※quasi-baseline§ (December 2004, 0–6 mo after publication), in April 2005 (4–10 mo after publication), and in October 2005 (10–16 mo after publication). Potentially confounding variables, including number of authors, authors' lifetime publication count and impact, submission track, country of corresponding author, funding organization, and discipline, were adjusted for in logistic and linear multiple regression models. A total of 1,492 original research articles were analyzed: 212 (14.2% of all articles) were OA articles paid by the author, and 1,280 (85.8%) were non-OA articles. In April 2005 (mean 206 d after publication), 627 (49.0%) of the non-OA articles versus 78 (36.8%) of the OA articles were not cited (relative risk = 1.3 [95% Confidence Interval: 1.1–1.6]; p = 0.001). 6 mo later (mean 288 d after publication), non-OA articles were still more likely to be uncited (non-OA: 172 [13.6%], OA: 11 [5.2%]; relative risk = 2.6 [1.4–4.7]; p
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' h/ r' e: D; r/ _/ A  E. h5 b$ o1 A0 X# @0 rFunding. The author received no specific funding for this study." g) K, [7 [0 T, A7 `+ X3 X
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E-mail: geysenba@uhnres.utoronto.ca
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Introduction
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/ {; z% K; K& z$ B+ gOpen access (OA) to the scientific literature means the removal of barriers (including price barriers) from accessing scholarly work. There are two parallel ※roads§ towards OA: OA journals and self-archiving [1,2]. OA journals make published articles immediately freely available on their Web site, a model mostly funded by charges paid by the author (usually through a research grant). The alternative for a researcher is ※self-archiving§ (i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites [including so-called repositories or archives]), which is a practice allowed by many scholarly journals.
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' M) a4 m8 S( _OA raises practical and policy questions for scholars, publishers, funders, and policymakers alike, including what the return on investment is when paying an article processing fee to publish in an OA journal, or whether investments into institutional repositories should be made and whether self-archiving should be made mandatory, as contemplated by some funders [3].
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* e3 H$ R  U  V4 T, y  lAmong the arguments of OA proponents (and an expectation of scientists who publish OA articles) is that ※open§ work is more quickly recognized, as measured by citations. Critics of OA dispute this fact and argue that there is ※no evidence that this will happen.§ [4] Representatives of traditional publishers argue that the ※established system of scientific/technical/medical publishing provides excellent levels of open access to scientists and the public alike,§ implying that scientists have access to the literature anyway and that there would be little advantage to publish OA. [5]* G$ ?0 V  E6 b

6 G! |! w2 ~0 y* r. q2 r3 hIn fact, the evidence on the ※OA advantage§ is controversial. Previous research has based claims of an OA citation advantage mainly on studies looking at the impact of self-archived articles or articles that are found online (※openly accessible,§ which some have argued to be different from open access in the narrower sense [6]). Most studies show an association between being online and being cited more often [1,7–9], although another study in the field of pediatrics seemed to suggest the opposite [10].
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All these previous studies are cross-sectional and are subject to numerous limitations.( n' E1 [! s" m- y" d8 h' ]$ d

' B+ x! R# s) t7 k" J. Y. {: F& a# vThe first problem is self-selection. As most of these previous studies broadly define OA as ※being found freely available online,§ [7,9] alternative explanations for citation differences include that important (high-citation) articles are more likely to be posted online by authors or users as a result of the articles' importance; for example, because they are used for journal clubs [6] or coursework, or because authors post them on their homepages because they get so many requests from peers (Wren found that online accessible papers are clearly biased towards publications with ※higher popular demand§ [6]). In other words, one could argue that the articles are online because they are highly cited, rather than being highly cited because they are online. A mere association in a cross-sectional study tells us nothing about the direction of the relationship. Kurtz even argues that ※the claims that the citation rate ratio of papers openly available on the internet versus those not available is caused by the increased readership of the open articles#(※OA advantage§) are somewhat overstated.§ [11] Similarly, while the usual line of argument is that self-archiving leads to higher citations [8], alternative explanations include that top authors are more likely to be at top institutions that may be more likely to have an institutional repository, which smaller institutions do not have, or that authors selectively self-archive their best work as a ※trophy.§ [6] A recent analysis of articles published in four mathematics journals indicates that articles deposited in the arXiv (http://arXiv.org) received more citations than nondeposited articles, but the authors do not attribute OA as the cause of more citations, but self-selection (quality differential) [12].
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Secondly, especially in fields like physics, where pre- and post-publication on http://arXiv.org is quasi-standard, a relationship between self-archiving and higher citation may be due to other factors, such as earlier dissemination of results through preprints [11], a quality improvement through discussion of preprints [13,14], or an ※outsider§ position of authors who do not self-archive.! v7 r9 `+ Z" S1 v: e  l
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Thirdly, previous studies reported crude, unadjusted rate ratios, where differences in author and article characteristics between OA and non-OA publications were not taken into account and corrected for. One could argue that the observed citation advantages of self-archived papers are a result of confounders; for example, publications with more authors are more likely to be self-archived (as it takes only one author to self-archive) and are also (independently from any OA effect) cited more often (e.g., through increased self-citations or because they might be of higher quality).5 {3 b* r9 Q* n5 _. J+ s8 z

8 w# }' V- O% d4 }/ U% dLimited or no evidence is available on the citation impact of articles originally published as OA that are not confounded by the various biases and additional advantages of self-archiving or ※being online§ that contribute to the previously observed OA effects. A ※journal-level§ analysis of journal impact factors concluded that OA journals are more often in the lower half of their subject category, although within the collection of OA titles, these journals ranked higher by immediacy index than by impact factor [15]. However, comparing the impact of OA journals against non-OA journals ignores differences in the journals' novelty, editorial policies, quality of peer review, and acceptance policies, which are strong confounders that are difficult to adjust for.
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$ K, u6 f: p) BTo answer the question of whether OA publications lead to a citation advantage I chose an article-level approach, comparing the bibliometric impact of a cohort of articles from the same journal (Proceedings of the National Academy of Sciences [PNAS]) that offers both an OA and a non-OA publishing option, adjusted for different article and author characteristics.3 H: F7 P1 q$ c. I4 k8 n" s

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Article and Author Characteristics  A1 [5 x+ E6 h  p. i% D
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A total of 1,492 original articles were included: 212 (14.2% of all articles) were published as immediate OA articles on the journal site, and 1280 (85.8%) as non-OA articles. On December 31, 2004, the articles in the cohort had been published (in most cases, electronically before print publication) within the last 194 d (mean, 101 d; SD = 57.5), with OA articles being on average younger (83.6 d; SD = 50.2) than non-OA articles (104.0 d; SD = 58.1) (p
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Article Characteristics. i% x2 n, X  B8 f3 `

: {* x0 u1 _( M# I$ e2 F! OAuthors came from 39 different countries, with the majority (n = 981; 65.8%) from the United States. Together, 12 countries constituted 95% of all the articles, and all had a minimum of ten articles each; other countries were aggregated in an ※other§ category. Among these 12 countries, Japan had the highest proportion of OA articles (13/67; 19.4%), followed by Israel (3/16; 18.8%), Germany (11/70; 15.7%), and the United States (152/981; 15.5%). Countries with the lowest proportion of OA articles included Switzerland (0/22), the Netherlands (0/17), Sweden (1/31; 3.2%), the United Kingdom (7/84; 8.3%), and Canada (3/31; 9.7%).
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% A; Y+ @, B  g1 Y3 u* o8 U' v& I4 U- `The majority (1,304/1,492, or 87.4%) of papers were from one of 14 major subject areas; the remaining smaller subjects were aggregated into an ※other§ category. Biochemistry was the largest article category (n = 190; 12.7%), followed by medical sciences (n = 152; 10.2%) and neuroscience (n = 149; 10.0%). The subject areas with the largest proportion of OA articles were microbiology (21/91; 23.1%), genetics (18/90; 20.0%), and evolution (12/71; 16.9%), while plant biology (2/53; 3.8%), chemistry (4/62; 6.5%), and biophysics (11/136; 8.1%) were subject areas with the lowest proportion of OA articles.2 ]7 R- \# I& [  u- G% H# k
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There was a borderline-significant trend towards OA first authors having more lifetime publications, with no significant differences between the groups for last authors' publication counts (first authors: OA median = 70.5 versus non-OA = 38.0; Z = 2.013, p = 0.0441; last authors: OA = 194.5 versus non-OA = 170.5; Z = 0.670, p = 0.503), perhaps pointing to the fact that first authors tended to be more senior in the OA group. There were significant differences between the groups in the authors' lifetime average citations per paper, with first authors being ※stronger§ in the non-OA group, and last authors being better in the OA group (first authors: OA median = 7.77 versus non-OA = 8.98; Z = 2.304, p = .02; last authors: OA = 13.64 versus non-OA = 16.35; Z = 3.456, p
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Among the 237 participants of the author survey (response rate, 75.4%), there were no statistically significant differences between the groups in self-rated relative urgency, importance, and quality of their particular PNAS article (p > 0.05).
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Citations
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! u  m* x6 g, t+ `% L9 B7 }Crude analysis. In the crude analysis, the mean number of citations as well as the proportion of articles cited at least once was significantly higher in the OA group in both the April 2005 and the October 2005 analyses, with the relative ※risk§ for non-OA articles of not being cited increasing over time (Table 2).
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% h8 X' n* V8 ?6 K( jCrude (Unadjusted) Analysis
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. k+ ^- y. h" D2 GIn an analysis stratified by subject, there was a trend for an OA citation advantage in almost all subjects, although, due to the limited number of articles per subject area, few of these differences reached statistical significance (unpublished data).& h9 q! h( F' _* r5 F. O0 K

2 g4 a' ^% M% k) ?. |; ZAdjusted analyses. A number of potential confounders must be considered and adjusted for to correct for differences in the number of authors, past productivity (or author seniority), time since publication, and submission track, which differ between the article groups and could be independently related to the probability of getting cited.% o( I8 p0 q. w8 _( R0 W5 }

9 ^; D' l  B# H+ CAs shown above, in the crude analysis, the proportion of uncited articles differed significantly between the groups at all three analysis points (Table 2). In order to determine whether these differences remained significant when adjusted for potential confounders, a logistic regression predicting ※cited§ status as dependent variable and with stepwise backwards elimination of potential predictors and confounders that were not statistically significant was conducted, controlling for first and last author's lifetime publication count, first and last author's lifetime average citations per paper, number of days since publication (categorized), number of authors (categorized), country of the corresponding author (12 most common countries and ※other§), funding type, subject area (14 most common subjects and ※other§), and submission track. OA status remained an independent predictor for being cited for all three analysis points, with an increasing odds ratio over time in favor of OA articles (Table 3).) `$ O) |1 a0 J8 z; f0 h; v3 q

0 E, c: M+ w) n5 b/ nOdds Ratios (with 95% Confidence Intervals) of Significant Predictors from a Stepwise Backward Logistic Regression Model (for Three Points in Time) with ※Cited§ Status as the Dependent Variable and OA Status as Well as Potential Confounders as Independent Variables$ R5 a0 g" p) T8 c- r3 D$ C

$ C$ v5 B2 ?# @/ N% r# A0 ?Similarly, using a stepwise backward linear regression model including the same covariates, OA status remained a significant independent predictor for the number of citations (transformed on a logarithmic scale) both in the April 2005 analysis (beta for OA status = 0.187; p 5 Z) R* j& P( n5 A) |

8 o% Z3 d# k  h6 G0 zSecondary Analysis
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PNAS allows authors to ※self-archive§ their research on the Internet even if they choose the non-OA option. This means that some of the articles in the non-OA group may in fact have been ※openly accessible§ online through the author's homepage or an institutional repository. In a secondary analysis I also analyzed citations of ※self-archived OA§ articles (i.e., self-archived or otherwise openly accessible on other Web sites than http://www.pnas.org or http://pubmedcentral.org), with the explicit caveat that articles which are found on the Internet are subject to self-selection and other biases as discussed in the introduction (i.e., it is impossible to discriminate whether they are on the Internet because they are important, or whether they are highly cited because they are on the Internet).& R2 B+ f: s! }5 R) d
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Citation rates (as of October 2005) of four separate subgroups were analyzed, as an article could be either published under the PNAS immediate OA option or ※self-archived,§ or both, or none. There was a clear relationship between the level of openness and the citation levels (Table 4).
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Secondary Analysis with ※Self-Archived§ (Openly Accessible Articles Found on the Authors' Homepages, in Institutional Repositories, or Elsewhere on the Internet) as Separate Subgroup (October 2005 Analysis, 10–16 mo after Publication)% @- V4 }! H( o' {0 ^

7 V& W) z, [" Y1 U% G: AWhile 36 of 212 (17.0%) of immediate journal OA articles were also self-archived, only 121 of 1,280 (10.6%) of non-OA papers on the journal site were self-archived (i.e., papers published originally as OA were more likely to be self-archived [Fisher's exact test p = 0.002]).- J% N. t8 b4 d& S
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The 1,159 papers which were neither self-archived nor immediate journal OA articles had on average 4.4 citations, whereas the 334 papers which were either self-archived or published originally as OA (or both) had 5.9 (Z = 4.215, p * m, l9 P# a7 z( |  H  `

8 E* T2 v0 c" J/ u8 l" lWhile in the crude analysis self-archived papers had on average significantly more citations than non–self-archived papers (mean, 5.46 versus 4.66; Wilcoxon Z = 2.417; p = 0.02), these differences disappeared when stratified for journal OA status (p= 0.10 in the group of articles published originally as non-OA articles, and p = 0.25 in the group of articles published originally as OA).3 ~7 R8 \/ V! O" S# x
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In a logistic regression model with backward elimination, which included original OA status and self-archiving OA status as separate independent variables as well as all potential confounders, self-archiving OA status did not remain a significant predictor for being cited. In a linear regression model, the influence of the covariate ※article published originally as OA, without being self-archived§ (beta = 0.250, p
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" m( ~. f3 j/ s+ f' p% wDiscussion
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4 Q+ w3 H- r3 d8 @- BMain Findings$ J# g* x) o3 h

& k* f5 A& v! N4 W; R; |This comparison of the impact of OA and non-OA articles from the same journal in the first 4–16 mo after publication shows that OA articles are cited earlier and are, on average, cited more often than non-OA articles. To my knowledge, this is the first longitudinal study of a cohort of OA and non-OA articles providing direct and strong evidence for preferential or earlier citation of articles published originally as OA. It is also the first study showing an advantage of publishing an article as OA on the journal site over self-archiving (i.e., making the article otherwise online accessible).! {  l; X$ G1 z# F. p
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The strength of the OA effect is particularly surprising because PNAS is a widely available journal that is accessible for most researchers through their library. In addition, articles are made freely available to nonsubscribers 6 mo after publication. The effect of OA publishing may be even higher in fields where journals are not widely available and where articles from the control group remain ※toll-access.§
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, i; L( t4 u" M; _0 QLimitations2 u. G( s, `# }7 ?* x2 @% {

' S  [' v* w1 g) L( g$ eThis study offers only a short-term glimpse at what happens at the left-hand (early) side of the temporal citation curve. A citation curve plotting over time the number of new citations per year to articles published in a certain year would show a sharp increase of new citations with a citation peak after 1 or 2 y (which is typically the time needed for citing authors to prepare and publish their papers), with a slow and steady decline of new citations year after year. Despite the narrow observation window of this study, it appears that publishing OA does not merely lead to a steeper increase and ※left-shift§ of the citation curve by 6 mo, because such a left-shift is incompatible with the observation in this study that there are still increased citation rates for OA articles at our third observation point 10–16 mo after publication. Rather, there seems to be a sustained effect on the absolute number of citations. In other words, there seems to be not only an advantage in terms of immediacy (defined as the average number of times that an article, published in a specific year within a specific journal, is cited over the course of the same year), but also in terms of total impact (as measured by the absolute number of citations received over a longer period of time). Future follow-up analyses following this cohort over a number of years will provide a more complete picture on how long-lasting the citation advantage of OA articles is.
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As this was an observational study and not a randomized trial, we were able to statistically control only for known confounders. There is a possibility of selection bias in authors judging the importance of their work and making a deliberate decision to publish their most important work as OA, with quality differences between articles contributing to citation differences. However, results from our author survey〞in which we asked authors to self-rate the importance and quality of their work〞did not show significant differences between the groups and do not make this likely, in particular because PNAS is a high-impact journal and most of the authors considered their work high quality in the first place.
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PNAS has a broad interdisciplinary scope and different submission tracks, which are features that should enhance the generalizability of the results. However, it has to be acknowledged that our data come from a single, rather atypical journal, and should be replicated with data from other newer hybrid (※author-choice OA§) journals. Other publishers have started to offer an author-choice option, but only recently and with limited sample sizes both in terms of articles and in terms of citations. While a study on these journals is under way, these results will be available only in a few years.. D3 w" a' _6 K  r
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This study used citations as a proxy for impact, and some may argue that ※it is hard to see how science will benefit by increased citation rates [of OA articles].§ [4] Our data do suggest that OA articles are more quickly recognized and their results are picked up and discussed by peers to a larger extent. It is hard to see how faster and increased utilization and uptake of research results will not benefit science, at least in terms of accelerating the speed by which new results are verified, falsified, or built upon by others. By focusing on citations this study only addresses the impact on other research users, not on the knowledge user (i.e., policymakers, consumers, or health professionals), but it can be hypothesized (and should be tested in future studies) that there is also a ※knowledge translation advantage§ in terms of increased and accelerated knowledge uptake by consumers and policymakers.2 ?' `  V- r( r
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Conclusions; X$ U% n) Y0 J& E! E6 d; Z
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OA journals and hybrid journals like PNAS, as well as traditional publishers like Blackwell Publishing (※Online Open§), Oxford University Press (※Oxford Open§), and Springer (※Springer Open Choice§) are now offering authors an immediate OA option if the author pays a fee. Researchers, publishers, and policymakers confronted with the question of whether or not to invest in OA publishing have reason to believe that OA accelerates scientific advancement and knowledge translation of research into practice. While more work remains to be done to evaluate citation patterns over longer periods of time and in different fields and journals, this study provides evidence and new arguments for scientists and granting agencies to invest money into article processing fees to cover the costs of OA publishing. It also provides an incentive for publishers seeking to increase their impact factor to offer an OA option.
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4 I8 _2 B7 x% y7 Y. RThe findings indirectly also support policies of granting agencies which made (or consider to make) OA publishing (be it only through self-archiving) mandatory for grantees [3], as it illustrates the advantage of openess in the dissemination of knowledge. However, this study suggests that publishing papers as OA articles on the journal site facilitates knowledge dissemination to a greater degree than self-archiving, presumably because few scientists search the Internet or Google for articles if they have encountered an access problem on the journal Web site.( V. ?& X# N7 T" \
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Materials and Methods
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( W7 G4 O& X# x1 V4 tArticle cohort.
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PNAS announced on June 8, 2004, that authors could pay US$1,000 if they wanted their article to be immediately OA [16] (as opposed to the usual non-OA ※moving wall§ model, where articles become freely accessible after 6 mo). The resulting mix of OA and non-OA articles published between June 8, 2004 (page 8745 of Volume 101), and December 20, 2004, in PNAS constituted the article cohort. Included were the article types ※Journal Article,§ ※Clinical Trials,§ and ※Case Reports,§ excluding editorials, commentaries, biographies, retractions, and retracted articles, ※classics§ papers, and supplement articles. To determine citation rates, Web of Science (Thomson ISI, Stamford, Connecticut) was searched on December 31, 2004, April 4, 2005, and again on October 4, 2005, for all articles citing papers from the cohort. Citation errors (e.g., wrong volume or misspelling of the author name) were manually corrected. The following article characteristics were extracted and used in the multivariate models in order to control for potential confounders: days since publication, number of authors, article type, country of the corresponding author, funding (as indexed in Medline), subject area (as classified in the PNAS Table of Contents), and submission track. PNAS has three different submission tracks: the majority (80%) of submissions are made through a regular submission track (called ※track II§), where authors submit manuscripts to the editorial office, which assigns an Academy member as editor to guide the paper through peer review [17]. PNAS has two further unique peer-review and submission models, called track I (authors submit their work directly to an Academy member, who solicits two reviews and then sends it to the editorial office for publication) and track III (Academy members can send their own articles to the editorial office, accompanied by peer-review reports which they themselves solicited) [18]. Including the submission track into the multivariate models allows control of different levels of rigor in peer review and quality of the contributions.
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To control for possible differences in ※author quality,§ information on the first and last authors' total number of published articles and lifetime citations up to 2004 was gathered from Web of Science and was also included as adjustment variables in the multivariate models.
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In addition, in order to test equivalence of article quality between the OA and non-OA groups, all authors with published and valid e-mail addresses (n = 313) received a Web-based survey in which they were asked to rate the relative urgency, importance, and quality of their particular PNAS article relative to other articles on a five-point Likert scale.
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9 j# z5 F  u2 c7 t; j. s- j- m& ZSecondary analysis.
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2 J" G8 D  L+ ^; X5 {& bTo identify ※self-archived§ articles I used a computer program (in-house development, see Acknowledgments) that conducted for each article a Google (http://www.google.com) phrase search, with the first sentence from the results section of the article or, if this did not lead to any hits, the digital object identifier as query. An article was considered ※self-archived§ if the article was found on Web sites other than on http://www.pnas.org or http://pubmedcentral.org. While this is not a perfect method (as Web coverage by search engines is incomplete [19]), it is currently the best we have, and if an article is not accessible through Google, it may not be found by the research community anyway and may not be considered ※openly accessible.§% z/ z% `9 C- {1 h9 m

3 z! |* v( I, L! zStatistics.4 y2 I$ R- @0 J: X* f0 b
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For crude comparisons of continuous variables (number of days since publication, number of authors, and citations), the nonparametric two-sided Wilcoxon Mann-Whitney test was used, as these data were not normally distributed. Proportions were compared using the Fisher's exact test, while categorical variables with multiple categories were compared between the two groups using the Freeman-Halton test (an extension of Fisher's exact test for r by c tables).4 Q$ t0 N% u+ {8 ^' o6 c) \

* H9 `4 L) C2 UIn multivariate models I tried to predict the number of citations from several article characteristics, including OA status, adjusted for potential confounders as independent variables. In a linear regression model, the number of citations as the dependent variable was transformed into a log scale, as the distribution was skewed, predicting log(citations 1). In a logistic regression model, the number of citations as the dependent variable was dichotomized into 0 (uncited) and ≡ 1 (cited).
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) G0 z* z, n; u! f- S( @+ T; XAll data were analyzed using SAS, version 8.02 (Cary, NC).
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6 \/ a4 Z, G, z% e" AAcknowledgments
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0 V, O( j6 f0 G% _" L9 zMJ Suhonos, Jean-Sebastian Dumais, Ali Faizan, and Alf Eaton coded various software applications for data collection, based on algorithms developed by the author.
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All cited Web pages in this article have been archived using WebCite (http://www.webcitation.org) [20] to allow future scholars to access cited online documents.
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Author contributions. GE conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, and wrote the paper.
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References
/ E* A  y. T; S; t
# P7 M" w9 y, A" v0 hHarnad S, Brody T, Vallieres F, Carr L, Hitchcock S, et al. (2004) The access/impact problem and the green and gold roads to open access Serials Review 30.+ a% t3 {0 [% r3 Z

" l% q; I2 h( _' J- k9 [8 a) O! SAnonymous. (2002 February) Budapest Open Access Initiative Available: http://www.webcitation.org/queryid=3046. Accessed 17 Nov 2005.$ L5 ~% Q; z% n9 q, I

" {) y; k! d. F' h8 s: G3 QAnonymous. (2005) RCUK position statement on access to research outputs Available: http://www.webcitation.org/queryid=3066. Accessed 17 Nov 2005.
" B* ]7 d0 j: Z+ e! H0 ~" ?8 v. x4 t1 [6 d7 P& h" L+ y
Aronson JK (2005) Open access publishing: too much oxygen BMJ 330:759.3 N( L8 _. }. B6 l- l1 x4 F+ b- @* X7 u

3 S# z( e7 j; I5 p& N. o+ aHunter K (2005) Critical issues in the development of STM journal publishing. Learned Publishing 18:51–55.
+ ]3 A  d4 S( o' o; d
  I' j' U/ k6 j  A) }Wren JD (2005) Open access and openly accessible: A study of scientific publications shared via the internet. BMJ 330:1128.
9 v( ?, R# |" ~. q
; h8 N, L7 g6 V; g% D" E8 qLawrence S (2001) Free online availability substantially increases a paper's impact. Nature 411:521.1 R% Y5 _; U4 `% T' C# I1 [7 F' R# U
% J" x/ Y: q9 j( k  A
Harnad S, Brody T (2004) Comparing the impact of open access (OA) vs. non-OA articles in the same journals. D-Lib Magazine 10.
: F6 V: E& q3 g. i* l6 @" Y* E: u3 [. C8 D9 Q
Antelman K (2004) Do open access articles have a greater research impact College and Research Libraries 65:372–382.2 Q9 |% G0 g8 f0 B9 M
! v5 K+ n4 V' ^4 B3 h' b9 I0 A
Anderson K, Sack J, Krauss L, O'Keefe L (2001) Publishing online-only peer-reviewed biomedical literature: Three years of citation, author perception, and usage experience J Electr Publ 6.
8 h5 k" `  L2 E& C/ V: k7 v' N9 W. p( O) r* g; |( e5 G$ Y
Kurtz MJ, Eichhorn G, Accomazzi A, Grant C, Demleitner M, et al. (2005) The effect of use and access on citations Available: http://arxiv.org/abs/cs.DL/0503029. Accessed 17 Nov 2005.
& ~; Z8 `- A" f( _7 M  V
( C1 d/ V6 s2 xDavis PM, Fromerth MJ (2006) Does the arXiv lead to higher citations and reduced publisher downloads for mathematics articles [draft manuscript. Last updated Mar 20, 2006] Available: http://arxiv.org/ftp/cs/papers/0603/0603056.pdf. Accessed 21 Mar 2006.
2 p, x$ ]0 l; G2 F- u
9 f$ N4 m1 ]5 S) x6 Z2 s9 M0 \Eysenbach G (2000) The impact of preprint servers and electronic publishing on biomedical research. Curr Opin Immunol 12:499–503.
. ]" \$ L7 W" D
, Q6 f9 _; c/ v0 OEysenbach G (1999) Challenges and changing roles for medical journals in the cyberspace age: Electronic pre-prints and e-papers. J Med Internet Res 1:e9.
# V* _! m; \1 l1 q6 j2 Z4 v9 [4 a$ {" c* r3 J
McVeigh ME (2004) Open access journals in the ISI citation databases: Analysis of impact factors and citation patterns Available: http://www.webcitation.org/queryid=95154. Accessed 13 Dec 2005.
+ ]. s, \" {* z0 f( q/ i' r) t. p7 P4 F" ~
Cozzarelli NR (2004) An open access option for PNAS [editorial]. Proc Natl Acad Sci U S A 101:8509.9 u( L7 c# p  T) {, J/ D. t. s* Z! U  J! e
: f7 D3 V/ E  q3 @( \2 \
Cozzarelli NR (2003) PNAS at volume 100 [editorial]. Proc Natl Acad Sci U S A 100:3005–3006.
; V6 |$ v0 A2 W% E
, n! j4 l! ~: m2 S; [3 HAnonymous. (2006) PNAS Information for Authors Available: http://www.webcitation.org/queryid=1139005746706997. Accessed 3 Feb 2006.6 o- M+ T* A, L3 @
2 l* \$ C% ?1 y, r2 r, Y
Lawrence S, Giles CL (1999) Accessibility of information on the web. Nature 400:107–109.! {# z! p  d8 Z% K5 B8 I
# s3 M" @* [! D8 U4 V* V6 j
Eysenbach G, Trudel M (2005) Going, going, still there: Using the WebCite service to permanently archive cited web pages. J Med Internet Res 7:e60.(Gunther Eysenbach)
作者: beautylive    时间: 2015-5-29 08:35

我想要`~  
作者: immail    时间: 2015-6-14 14:06

说的不错  
作者: beautylive    时间: 2015-6-17 20:43

天啊. 很好的资源
作者: xuguofeng    时间: 2015-6-27 12:03

这个贴好像之前没见过  
作者: 昕昕    时间: 2015-8-3 20:27

不错 不错  比我强多了  
作者: 命运的宠儿    时间: 2015-8-5 19:18

每天都会来干细胞之家看看
作者: marysyq    时间: 2015-8-21 06:53

不看白不看,看也不白看  
作者: biobio    时间: 2015-8-24 15:01

每天早上起床都要看一遍“福布斯”富翁排行榜,如果上面没有我的名字,我就去上班……  
作者: sky蓝    时间: 2015-9-19 11:01

有才的不在少数啊  
作者: marysyq    时间: 2015-9-19 22:53

干细胞之家
作者: 依旧随遇而安    时间: 2015-10-5 11:27

不错啊! 一个字牛啊!  
作者: aakkaa    时间: 2015-10-28 19:00

干细胞之家是国内最好的干细胞网站了
作者: haha3245    时间: 2015-11-4 16:27

ding   支持  
作者: tuanzi    时间: 2015-11-28 17:27

其实回帖算是一种没德德,所以我快成圣人了  
作者: tempo    时间: 2015-12-7 09:55

不错,看看。  
作者: aakkaa    时间: 2016-1-8 15:35

观看中  
作者: biobio    时间: 2016-1-26 21:42

角膜缘上皮干细胞
作者: xiao2014    时间: 2016-2-29 14:17

必须顶  
作者: HongHong    时间: 2016-3-6 16:05

不错的东西  持续关注  
作者: na602    时间: 2016-3-29 20:54

回复一下  
作者: doc2005    时间: 2016-4-7 08:27

楼主,支持!  
作者: 8666sea    时间: 2016-4-7 16:35

不错不错,我喜欢看  
作者: 我学故我思    时间: 2016-4-23 12:17

强人,佩服死了。呵呵,不错啊  
作者: doc2005    时间: 2016-4-26 19:43

不错啊! 一个字牛啊!  
作者: 温暖暖    时间: 2016-7-25 11:27

干细胞研究还要面向临床
作者: 糊涂小蜗牛    时间: 2016-8-2 14:32

回贴赚学识,不错了  
作者: pcr    时间: 2016-8-3 07:18

留个脚印```````  
作者: 命运的宠儿    时间: 2016-8-8 06:39

对不起,我走错地方了,呵呵  
作者: biodj    时间: 2016-8-21 20:26

自己知道了  
作者: 罗马星空    时间: 2016-9-9 16:41

谁都不容易啊 ~~  
作者: 杏花    时间: 2016-9-12 17:41

我在顶贴~!~  
作者: tuanzi    时间: 2016-9-17 18:01

天啊. 很好的资源
作者: tian2006    时间: 2016-10-22 12:27

你还想说什么啊....  
作者: apple0    时间: 2016-12-26 01:00

不错!  
作者: dypnr    时间: 2017-2-8 15:08

进行溜达一下  
作者: 石头111    时间: 2017-3-5 15:54

希望可以用些时间了~````  
作者: yunshu    时间: 2017-3-17 12:35

好啊,谢楼主
作者: 碧湖冷月    时间: 2017-4-13 16:41

顶顶更健康,越顶吃的越香。  
作者: dada    时间: 2017-5-17 21:06

不对,就是碗是铁的,里边没饭你吃啥去?  
作者: ringsing    时间: 2017-5-19 14:01

文笔流畅,修辞得体,深得魏晋诸朝遗风,更将唐风宋骨发扬得入木三分,能在有生之年看见楼主的这个帖子。实在是我三生之幸啊。  
作者: 风云动    时间: 2017-5-29 14:43

不是吧  
作者: xiao2014    时间: 2017-6-8 22:26

好啊,,不错、、、、  
作者: marysyq    时间: 2017-6-20 14:27

原来这样也可以  
作者: 王者之道    时间: 2017-6-28 01:10

自己知道了  
作者: 修复者    时间: 2017-7-21 17:34

干细胞研究还要面向临床
作者: 蝶澈    时间: 2017-8-15 08:54

顶的就是你  
作者: 墨玉    时间: 2017-9-1 16:10

生殖干细胞
作者: tuanzi    时间: 2017-9-2 13:34

彪悍的人生不需要解释。  
作者: 小倔驴    时间: 2017-9-11 01:05

今天没事来逛逛  
作者: mk990    时间: 2017-9-23 02:54

说的真有道理啊!
作者: 旅美学者    时间: 2017-9-23 10:28

一个有信念者所开发出的力量,大于99个只有兴趣者。  
作者: awen    时间: 2017-10-14 03:43

努力,努力,再努力!!!!!!!!!!!  
作者: 桦子    时间: 2017-10-24 11:27

不对,就是碗是铁的,里边没饭你吃啥去?  
作者: 若天涯    时间: 2017-10-28 16:10

每天到干细胞之家看看成了必做的事情
作者: 糊涂小蜗牛    时间: 2017-11-19 16:26

干细胞研究人员的天堂
作者: heart10    时间: 2017-11-29 15:27

很好!很强大!  
作者: xuguofeng    时间: 2017-12-1 21:35

谢谢分享  
作者: aakkaa    时间: 2017-12-16 03:56

干细胞之家是不错的网站
作者: HongHong    时间: 2017-12-31 14:17

不错!  
作者: marysyq    时间: 2018-1-24 05:01

说的不错  
作者: ladybird    时间: 2018-2-13 07:15

彪悍的人生不需要解释。  
作者: nosoho    时间: 2018-2-21 05:59

皮肤干细胞
作者: 张佳    时间: 2018-3-21 06:35

来上茶~~~~  
作者: lab2010    时间: 2018-4-14 13:01

表观遗传学
作者: dreamenjoyer    时间: 2018-4-20 01:15

既然来了,就留个脚印  
作者: 丸子    时间: 2018-5-20 08:10

哈哈,有意思~顶顶 ,继续顶顶。继续顶哦  
作者: Kuo    时间: 2018-6-4 04:45

这个贴不错!!!!!  
作者: 橙味绿茶    时间: 2018-6-20 00:57

好帖子,要顶!
作者: renee    时间: 2018-7-8 22:58

哈哈 瞧你说的~~~  
作者: hmhy    时间: 2018-7-13 15:09

风物长宜放眼量  
作者: xuguofeng    时间: 2018-7-16 03:09

我是来收集资料滴...  
作者: doc2005    时间: 2018-7-17 23:30

怎么就没人拜我为偶像那?? ~  
作者: tuting    时间: 2018-7-19 14:09

好贴坏贴,一眼就看出去  
作者: 小敏    时间: 2018-7-29 10:35

转基因动物
作者: 龙水生    时间: 2018-8-6 11:01

爷爷都是从孙子走过来的。  
作者: awen    时间: 2018-8-21 05:49

慢慢来,呵呵  
作者: doors    时间: 2018-8-26 23:53

小生对楼主之仰慕如滔滔江水连绵不绝,海枯石烂,天崩地裂,永不变心.  
作者: 石头111    时间: 2018-9-4 03:31

好啊,谢楼主
作者: 科研人    时间: 2018-9-8 23:43

今天无聊来逛逛  
作者: 与你同行    时间: 2018-9-10 20:41

一楼的位置好啊..  
作者: 8666sea    时间: 2018-9-29 00:18

干细胞之家 我永远支持
作者: dr_ji    时间: 2018-10-10 19:17

哈哈,有意思~顶顶 ,继续顶顶。继续顶哦  
作者: 石头111    时间: 2018-10-15 17:43

厉害!强~~~~没的说了!  
作者: changfeng    时间: 2018-11-7 02:44

脂肪干细胞
作者: 分子工程师    时间: 2018-11-26 16:27

说的不错  
作者: 海小鱼    时间: 2018-11-26 23:20

干细胞存储  
作者: immail    时间: 2018-12-7 03:05

肿瘤干细胞
作者: myylove    时间: 2018-12-9 18:13

胚胎干细胞
作者: lalala    时间: 2018-12-24 02:38

越办越好~~~~~~~~~`  
作者: dmof    时间: 2018-12-31 19:19

孜孜不倦, 吾等楷模 …………  
作者: 丸子    时间: 2019-1-16 14:51

干细胞之家 我永远支持
作者: netlover    时间: 2019-1-21 06:10

我又回复了  
作者: s06806    时间: 2019-2-15 09:17

哈哈 瞧你说的~~~  
作者: happyboy    时间: 2019-2-21 18:34

也许似乎大概是,然而未必不见得。  
作者: whyboy    时间: 2019-2-27 08:09

努力,努力,再努力!!!!!!!!!!!  
作者: 剑啸寒    时间: 2019-3-11 13:54

干细胞疾病模型
作者: ikiss    时间: 2019-3-20 15:35

帮你项项吧  
作者: 咕咚123    时间: 2019-4-16 11:00

感觉好像在哪里看过了,汗~  
作者: popobird    时间: 2019-4-19 11:27

加油啊!!!!顶哦!!!!!  




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