Foundations of Systems Biology: Using Cell Illustrator and Pathway Databases (Computational Biology) ; H9 L; p6 @! R0 z @( E
Publisher: Springer |. l3 ]: n T9 {& O: \. O! ZNumber Of Pages: 156 . ~! P4 s/ e9 H/ I; `( i8 z3 Y* D: l4 E
Publication Date: 2009-04-30 ( X! h) O: D+ O, q. L" L9 H) i* a
ISBN-10 / ASIN: 1848820224 ; X8 I, V |; U1 O! VISBN-13 / EAN: 9781848820227 - q/ w3 ]1 n8 R
, R8 Y* u U9 X" y * h$ C" E5 E) W( _" a5 a! l# L, V( a& KProduct Description: : P" C3 F& T5 U& h! t0 F! S7 }5 K) g ' f' r4 d, K% j$ `& a5 V* z3 p% P& l5 b G
Navigating safely through a wealth of genome, protein and metabolite information, as well as a host of information processing tools, without getting lost is crucial for successful research in – and teaching of - molecular biology.7 Q; X3 Q: K; _ T* u
6 ?' }) W' P* l' U8 CThis concise, easy-to-follow textbook/guide serves as a valuable introduction to contemporary cell biology for readers and offers insight into the key research directions in the field. It begins with an overview of existing tools for finding, designing and investigating metabolic, genetic, signalling and other network databases. This practical guide then introduces Cell Illustrator, a software tool for biological pathway modelling and simulation, developed by the authors. In-depth discussion reveals how this tool can be used for creating, analysing and simulating biological models, thereby explicating and testing current understanding of basic biological processes. Readers do not require prior knowledge of differential equations or programming.; ]9 O D/ _4 E' ?3 \
. Y. |' j) q# m8 }: a) F$ SFeatures:& F Y: k5 I; W3 D! P
6 Z9 L8 C$ D8 g, u4 u• Provides many helpful learning aids, such as detailed examples throughout, and exercises and solutions + Z' N: W0 P; I) G% w0 \, w3 m4 U 5 V* i, z7 B- C, {, w' Q• Designed and structured to be part of a semester-long course, e& Q# X$ j) x& Z/ \( ^
A D- C$ W5 N, x/ M6 m• Discusses the computational functionalities required for Systems Biology- h- ^3 q( R" b$ ^
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• Addresses practical issues surrounding software tools L8 H' ?+ Y6 j* e% {+ ~* v1 e: X5 C& x1 O0 `
• Introduces the current big bio-databases such as TRANSPATH® by Biobase, and explains why and how they can be used to develop and support systems biology research; Y0 G6 r* I8 @5 \
. ^! N* H: t1 R- {$ g, F• Includes a CDrom containing Cell Illustrator that allows readers to create highly complex pathways and simulations % R- M) c) L3 U! {1 e# K1 J- B0 I5 Q8 t6 Y4 f
• Explains important pathway databases and software tools, together with their related concepts 2 c, j; V: G G( d0 g+ T8 p4 @6 Q) p1 E N) `
• Guides the reader to model pathways in a step-by-step and clear manner8 }: X3 n: L5 N0 U; A% H
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• Contains a Foreword written by Professor Andreas Dress, Director CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences% `) a' C) r/ O
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Written for undergraduates, this reader-friendly introduction to the field of Systems Biology offers insight and teaches sound expertise in the subject. It will also prove valuable to graduate students and professionals wishing to develop and support their systems-biology research.! U6 q- ^: `4 C" e3 P0 A. V
Stem Cells and Cancer (Cancer Drug Discovery and Development) . @$ c% U4 S! J# H r6 z/ r ?. F1 [ 6 M. J6 d: U3 F& d; a7 I2 l( b: mPublisher: Humana Press q! W5 G- d5 @' H+ J2 qNumber Of Pages: 330 + w4 g: V0 z* x8 L: D# Y( p
Publication Date: 2009-05-07 / _4 T$ c6 f5 P9 C
ISBN-10 / ASIN: 1603279326 ! v2 K4 q# l( }1 d3 W. E, DISBN-13 / EAN: 9781603279321 # L ~% M* F1 O, z. q8 N4 o
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7 R- K9 l2 O1 y: }! _& _$ [The discovery of stem cells has ignited a field of discovery in many human disease areas including diabetes, neurology, and cancer. The tissues from which stem cells have been derived for research have become controversial over the years. Stem cells hold promise in the treatment of debilitating diseases as a new source of therapy. While stem cells may provide therapeutic benefit under certain conditions, stem cells have most recently been implicated in the progression and aggressiveness of certain cancers. 9 Q$ ?. ~1 O- H8 a# E4 l8 u) J1 i& \2 h+ `% e2 M
Stem cells are characterized by the potential to self-renew, to differentiate, and can sustain tumor growth. Cancer stem cells have been implicated in a variety of tumor types including gliomas, breast, colon, and prostate carcinomas. Hematopoietic stem cell malignancies have been demonstrated in contributing to hematological malignancies such as leukemia. Mesenchymal stem cells have also been implicated in progression of disease. The stem cell niche or microenvironment also plays an important role in nurturing stem cells until their release and mobilization towards sites of active tumorigenesis.' u9 @+ Y$ X- E# X
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Product Description: 6 f, i' `" H0 z% Q4 ?
/ a- Q$ }: r0 m1 I- m3 x2 f 9 M" S: n% E4 o+ SThe sense of smell has varied roles in locating food, detecting predators, navigating, and communicating social information, whereas the taste system is focused on decision-making in food intake. The last decade has witnessed massive advances in understanding the molecular logic of chemosensory information processing, and the results for taste sensation were found to differ in interesting ways from those for smell sensation. The 12 chapters of this book cover the current knowledge about the chemosensory systems in mammalian, fish and insect models. The advantages of the different model systems are emphasized. The genomic characteristics and evolution of olfactory and gustatory receptor gene families are analyzed, rules for odorant receptor gene choice and axonal projection of the corresponding receptor neurons are discussed, and the similarities and dissimilarities of pheromone vs. odorant sensing are examined as well as the molecular logic of mammalian sweet taste, bitter taste, and fat perception. Olfactory-guided and taste-guided behaviors are discussed, with a particular emphasis on the insect system.+ U w3 a. `& ~' j
4 W8 M" k8 J% V& B! H0 m9 W5 E http://rapidshare.com/files/225536626/GGP369.pdf作者: telomerase 时间: 2009-4-27 20:19
Trends in Stem Cell Biology and Technology Y0 k2 K; L7 Z7 Z$ j
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Publisher: Humana Press , L8 i w! N. O" [
Number Of Pages: 419 5 i- ?0 O) A: F: F* [9 b! {$ `Publication Date: 2009-05-12 4 y5 C3 A( j! l p
ISBN-10 / ASIN: 1603279040 5 K; H2 q$ m; ], Q4 y4 E' D0 |
ISBN-13 / EAN: 9781603279048 * {1 B" Q3 L* [4 o
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Product Description: ) z' \2 e2 T" R( t6 d! A, @* o 6 ]8 L2 d2 y7 E2 z1 M1 f. S . m- u; p, \; N7 ZThe study of stem cell research has recently gained the attention from a growing, multidisciplinary community of scientists; this exponential growth of interest is driven by the hope of discovering cures for several diseases through transplantation medicine. Trends in Stem Cells Biology and Technology aptly serves this developing community as it reveals new aspects of stem cell research by specifically covering studies focused on spermatogonial stem cells, uniparental embryonic stem cell lines, the generation of gametes from stem cells, reprogramming germ cells to stem cells, nuclear and somatic cell genetic reprogramming, tissue engineering and mechanotransduction of stem cells and finally the development of stem cell technologies for the treatment of deafness, heart disease, corneal injury and diabetes. @/ Z- X$ w) B2 E 7 m$ B( W+ s5 a) r9 C$ o1 ]With contributions by leading scientists and renowned scholars, Trends in Stem Cells Biology and Technology offers a wide audience cutting edge information at a crucial time in this ever expanding field.+ {5 Y* B; e- {+ S+ F! t, {& F
Emerging Technology Platforms for Stem Cells . S4 c: n' D* M" m# A+ F% I
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Publisher: Wiley ' D! X% C1 h; d* `: xNumber Of Pages: 505 . @) N4 I& j/ R6 C' C( l3 R
Publication Date: 2009-04-06 ) T" y% e! E7 f
ISBN-10 / ASIN: 0470146931 $ F. y$ X. Z- \( b0 a* uISBN-13 / EAN: 9780470146934 . W, v5 r5 J/ N$ B7 h) ^" m9 j! B' r4 y( @2 l4 w, }
. R: ]5 W" w& ~1 r% LProduct Description: 9 [4 n9 A0 f' T3 Y- a. s
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This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for professionals working in stem cell science, it presents the general principles and methodologies in stem cell research and covers topics such as derivitization and characterization of stem cells, stem cell culture and maintenance, stem cell engineering, applications of high-throughput screening, and stem cell genetic modification with their use for drug delivery.. c0 @7 l) n" q7 K2 ~+ H8 W
Regulatory Networks in Stem Cells (Stem Cell Biology and Regenerative Medicine) . n+ t* Y( t- d h# l $ ?* e# j- r! q; y- uPublisher: Humana Press p' b$ D' F& \" L4 y! w2 s9 gNumber Of Pages: 1126 ) R$ b! f: w" ?! P. E2 L
ISBN-10 / ASIN: 1603272267 6 w3 q' D" n; C& Q7 a- Q! lISBN-13 / EAN: 9781603272261 6 W7 y J9 k! ]+ l' u" g3 @- Y! v3 m y) {7 R. y* r$ b% |
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3 ?8 ` K4 c( N4 @0 } 7 H2 u. v1 A3 _" }5 |+ PThis book brings together current advances in embryonic, adult, neural, hematopoietic, mesenchymal and pancreatic stem cell functions. The chapters are authored by top-notch scientists in specialized areas of stem cell biology. Topics of the book focus on: Improved characterization of stem cells, Genomic alterations in stem cells during aging, Differential gene expression profiling during Quiescence, Self renewal and Differentiation, Stem Cell Transcriptomics and Proteomics, Regulatory feed back loops by stem cell transcription factors and post-transcriptional controls, Molecular Signaling Cross-talks in Stem cells, Transcriptional logics behind Nuclear Reprogramming, Clinical perspectives of Emerging Stem cell specific novel small RNAs (Piwi RNAs and MiRNAs), Epigenetic regulation and stem cell specification, and Stem cell niche and its functional significance in therapeutic interventions. The book will be an invaluable resource for researchers, scientists, and clinicians in the rapidly progressing field of stem cells and regenerative medicine.- v3 g, X* r' j0 _9 O) y1 l4 b
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Modelling Urban Development with Geographical Information Systems and Cellular Automata * p8 ^$ g- Q; Z; j; K) Q. B, f; H' o, y% {" d6 H# c, L
By Yan Liu ' D" y; G1 t% B" W# e6 h- y$ S4 b" u5 u% @. B; _
(December 10, 2008)4 J+ k# L3 z2 G9 e" q
, o: J- }. P8 a0 A7 pPublisher: CRC : t5 x2 X2 K4 D+ Y FNumber Of Pages: 240 8 L6 A5 `. W8 D2 x: f. WISBN-10 / ASIN: 1420059890 . r/ y2 F$ P. b( N! M
ISBN-13 / EAN: 9781420059892 ! M( a% I" k; |9 m6 \
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Urban development and migration from rural to urban areas are impacting prime agricultural land and natural landscapes, particularly in the less developed countries. These phenomena will persist and require serious study by those monitoring global environmental change. To address this need, various models have been devised to analyze urbanization and the physical, socioeconomic, and institutional factors impacting urban development. * \3 f0 K# R2 m! g! C- _. k2 E3 ~3 { ) n; X! ?4 \- [5 LThe most promising and rapidly developing of these paradigms take advantage of new Geographical Information System (GIS) technology. Modelling Urban Development with Geographical Information Systems and Cellular Automata presents one such cutting-edge model that is more than just predictive. It describes how the model simulates the urbanization process, and it provides theoretical context to promote understanding. Starting with a practical overview of the modelling techniques used in urban development research, the author focuses on the cellular automata model and its greatest strength – the incorporation of fuzzy set and fuzzy logic approaches through which urban development can be viewed as a spatially and temporally continuous process. % o2 Y/ h+ e2 i& y' [" T2 \, `0 t
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Real-Life Application to Develop Future Planning Methods " t! a! |" P& [# LThe text describes a landmark study underway, in which the fuzzy constrained cellular automata model has been implemented in a GIS environment to simulate urban development in Sydney, Australia. Featuring a survey of associated research and a geographical database for the Sydney simulation, this book answers many general “what if” questions for urban planners and details a new approach that they can adapt to their own testing and evaluation needs. This modeling method will provide researchers and planners with the means to not just predict population trends, but to better prepare for their consequences. 6 G* A; S' ^ V k9 I j
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4 j% E5 C. K7 G. O" W7 ]+ Q6 J9 T http://rapidshare.com/files/2060 ... llular_Automata.rar作者: telomerase 时间: 2009-4-27 20:26
Stem Cell Research (Introducing Issues With Opposing Viewpoints) 3 @" @, Y! d4 t" x9 U
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By Jennifer L. Skancke 4 L" L* W) o- u# H1 n9 H/ i, Y$ {% ~ P0 g: ?/ Q) o0 H
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/ p, m, i9 z9 R5 O8 o" o1 ]" u- r: Q ' u; a# ~# p! Z" a# {3 V/ t* S" }By Mary J. Laughlin, Hillard M. Lazarus * O& l' ?6 g3 c8 W* t P% k! y& W! @! K6 E; p; `' K 1 j: @+ c6 T, E$ q% o. z, @& l1 l" M
Publisher: Humana Press 3 z/ o8 Q0 v* P& d. O' Z
Number Of Pages: 454 5 M2 j" ^7 E. X9 K( f, Y9 h C, q1 b
Publication Date: 2002-11-08 " E. M7 m) ~; |6 _5 r0 B
ISBN-10 / ASIN: 089603979X % A. X% K, ?, T" S! MISBN-13 / EAN: 9780896039797 7 h' O) x, { {1 O" Y; n4 h; f1 C 9 t7 i4 S7 f& P: X' { 9 J6 {" e& r7 m, d+ @# a3 Q; e1 QProduct Description: 5 {5 T f# F) l5 L7 r1 l
. Q1 q+ k7 _& {0 w+ VCase Western Reserve Univ., Cleveland, OH. Text, for clinicians, presents a concise review of new developments, new findings on the kinetics of immune reconstruction, decision-tree analyses, and more. Comprehensive and current information on best clinical practice is included. DNLM: Hematopoietic Stem Cell Transplantation. 7 X+ ?$ K+ u; F0 `9 `: y! k/ O) R6 l0 o( L7 `* N http://ifile.it/lwn2ym8/089603979X.zip作者: telomerase 时间: 2009-4-27 20:30
The Proteus Effect: Stem Cells and Their Promise for Medicine & o n+ d3 c- @3 g. r, P
By Ann B. Parson+ Y( E2 h# x6 h3 n2 J( q6 n5 M
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Publisher: Joseph Henry Press $ x$ v- r5 t- V( Z: Y
Number Of Pages: 312 ) t* ^& f4 j+ y) d! L, W G# ~' p4 HPublication Date: 2004-09-21 : J* D, v2 _7 ^4 @8 h1 p8 BISBN-10 / ASIN: 0309089883 / J. m8 U. ?) z1 L g8 _ISBN-13 / EAN: 9780309089883 " l; D1 t# ]; H0 x; ]- I1 a # w% t: o' L+ t" i+ n( P8 G* Z4 D# u
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"Stem cells hold particular promise for unlocking life-saving secrets of the cell..." -- National Academy of Sciences 1 w6 a0 D: {& B! ]* Z5 b4 w
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Cutting edge stem cell research could pave the way to a bold new era in medicine, providing cell-based treatments -- perhaps even cures -- for scores of diseases and illnesses. But what exactly are these biological wonders -- these things called stem cells? And what promise do they really hold for medicine? As acclaimed author Ann Parson suggests, one way to measure the future is to first search back through the past to take stock of how humans have gradually awakened to these distinctive, often camouflaged, cells in our midst and slowly come to recognize their worth. ! k3 m; H [: t% V: i' B0 v
" F; d( v1 z0 q4 E$ MThe story of stem cell technologies is at once compelling, controversial, and remarkable. Part detective story, part medical history, The Proteus Effect describes early scientific discoveries that date back as far as 1740 before proceeding into the present to recount the incredible events leading to the discovery of stem cells in animal tumors, in the blood of mice, in the brains of canaries, in human embryos, and then in the skin, liver, and other organs of grown humans. It looks at the explosive potential of these special cells for the future of medicine. % m4 N& S: H, b) ~
; ]* d6 _; O. n9 g, PStem cells are the clay of life waiting for the cellular signal that will coax them into taking on the shape of the beating muscle cells of the heart, insulin-producing cells of the pancreas, or message-carrying cells of the central nervous system. Manipulate them the right way, turn them into the right type of cell, and it’s possible that stem cells could be used to counter (or cure) diseases such as Parkinson's, diabetes, heart disease, autoimmune disorders -- even infertility or baldness! 6 n, C! v& Q; j0 y, S6 ~2 E3 o* U% E
But should scientists be allowed to pick apart five-day-old embryos in order to retrieve stem cells? And when stem cells whisper to us of immortality -- they can divide and perpetuate new cells indefinitely -- how do we respond? Stem cells are forcing us not only to reexamine how we define the beginning of life but how we come to terms with the end of life as well. But these cells are such stunning creations that anyone stopping to peer at them cannot help but admire them for the qualities that go far beyond their uses as simple tools for human medicine. In the end, stem cells open our eyes to the presence of forces in Nature that are far greater than anything humans could imagine or invent. " S3 X6 Z- h: S0 `8 Z7 Z% [$ X% T" c7 H/ q
Meticulously researched, artfully balanced, and engagingly told, Ann B. Parson chronicles a scientific discovery in progress, exploring the ethical debates, describing the current research, and hinting of a spectacular new era in medicine. The Proteus Effect is as timely as it is riveting.( |" R) k& K r0 S) g
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9 _# O7 K' j' i1 {, X' E 4 S$ k) \) t' n4 }Summary: Well written - though vital info wasn't cited ( l0 I* t- c7 u# x' n% q, URating: 1$ N2 l3 s; }5 R& e. D6 ^
. |2 l7 v$ E$ N# G0 g! r; n5 [# JMs. Parson has the human touch of rendering scientific literature in a reader-friendly way, and for that she's to be commended. But as I mentioned in my much lengthier review of "Stem Cell Now" (by Scott), the reason I rated this with only one star, is solely because I wanted to get the message across that many stem cell authors, such as Parson & Scott, have omitted vital info. Namely, the electronic aspect of the body, and that injuries (or "salt-in-wound effect" and, IMO, also the UV-activated densely-packed salt at Dead Sea) create a "Current Of Injury" and that's what stimulates regeneration, as researched by Dr. Robert Becker (brilliant author of The Body Electric). ' d# Y% B+ F; O, `& m2 U2 j1 M
2 X; f6 h) T6 ]) DMany stem cell researchers & authors don't explain (as Becker did) about the importance of enabling a neuro-epidermal junction, such that channels remain open between the neurons and blastema, nor do they explain that positive & negative electromagnetic pulsing expedites the regenerative process, and that salamanders, who regenerate very easily have a higher proportion of neurons concentrated at their extremities than humans do, which is why they may heal so much more efficiently than humans. That's why Becker applied electronic pulses to expedite the healing process, and why his patient, who suffered an osteomyelitic, shattered leg, was so fortunate to have Becker as his doctor, rather than most other ponderously robotic quacks of the antiquated system. 2 c) C, Q8 r& [- }
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[ahem] you never know, maybe Ms. Parson, Mr. Scott, or some other science author will come across these reviews, and be motivated to write books which are more all-encompassing of the issues I hashed out, particularly the last few paragraphs of the Stem Cell Now review. N2 [- a3 f9 T
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Summary: Well balanced & engaging6 ]* n4 H! P2 B2 \0 P
Rating: 5/ i4 s k. ~1 B$ s% v( R0 h' \+ M
' b4 [/ C% G( {* s/ OParson has done an excellent job in presenting various aspects of the stem cell field in an engaging & vivid manner. Supported by her extensive research & interviews, the content of 'The Proteus Effect' is well balanced, with fascinating & concise information in areas including: history, science, people, commercial potential, political & ethical issues. It is refreshing to see how Parson managed to make a complicated science come to life. 7 @4 f* [$ d! W5 B : p$ Y' p6 W: P - F# J5 s x$ V W# ?4 Z
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Summary: A historical look at the discovery of the stem cell ! p1 ?/ u' x1 x% eRating: 5) B2 t- @0 x7 n* Q* K
& R# f, k3 h5 a% jAbraham Trembley and the hydra, Roy Stevens and Mouse 129, and the purple cell. ( t% Z% b* D: p3 p- J
8 o) a5 T& g4 V$ xThis is an important book to read because Anne Parson ties together the historical events and patterns that establish the modern understanding of the Stem Cell. / }- g3 q& \6 [9 B2 O
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Blood Stem cells. 25 Trillion blood cells exist in the blood and every second 2 million blood cells die and are replaced. The key was to find the pluripotent stem cell that differentiated into the blood cell. Find the original parent was like looking for a needle in a haystack. Researcher found that mice with defective bone marrow (damaged by radiation) could be restored by translates of marrow stem cells injected directly in the blood. The bone marrow transplant in essence restored the bone marrow stem cells to functional and normal status. u" i2 @" N7 |6 S; O T/ Y * h) R: d, c3 T" z( |2 \2 y* wHuman leukocyte antigens (HLA) protein are found on the surface of the the cell. The HLA help the immune system decide what cells are foreign and should be destroyed. The immune system destroys the cells by creating antibodies and other substances. 8 M L; ^4 g; T, A; |2 i
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In syngeneic transplants, patients receive stem cells from their identical twin. : G, X7 V! I( o- M" o! r) d- D$ o* y: w
Allogeneic transplants. The patients receive stem cells from someone other than the patient or an identical twin. For a bone marrow transplant to work, the recipient's immune system needs to have a way to keep the immune system (T-Cells) from destorying the donated marrow. The HLA in the donated donated marrow cells must be identical. - a% J8 x/ c% |5 X1 V c4 e 2 e6 ^: M; d; `& ^6 e4 C! q! NHLA-A, HLA-B, and HLA-DR were used to determine a match between a donor and recipient. A total of six antigens from the donor must match the six antigens of the recipient. 0 t) _$ G8 g3 w4 y' R: W" e
: \' g6 H; Z- y1 ?6 m. I* O* @Autologous transplants. The patient receives the harvested stem cells and these stem cell integrate and produce new blood cells. The harvested stem cells come from the blood, peripheral blood stem cell transplantation. The stem cells are frozen until they are ready to be transplanted. The patient receives the stem cells back into their blood. 5 ]; v M6 J# U' S0 v2 {. s1 k( f8 |# N8 z' L$ \
After entering the bloodstream, the stem cells travel to the bone marrow, where they begin to produce new white blood cells, red blood cells, and platelets in a process known as "engraftment." + u X7 l. T" U h6 L5 F' l
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Neurogensis. Female Canary bird brains could increase in size by introducing a hormone causing maleness destroying the myth that neurons did not produce after birth. In 1960, Joseph Altman found evidence of new cells in the hippocampus of an adult rat brain. In 1988, scientist showed the adult human brain produces new neurons. Stem cells in the brain produce either neurons or glia, the glue that holds the neurons together. After the neuron is generated, it migrates to a specific part of the brain and differentiates, as a, sensory neuron or motor neuron or interneuron. As the brain develops, molecular signals from other cells help determine the shape and location. s* E! q3 w- j( N! S
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Summary: A look at what research into fetal stem cells has to say I; X6 S4 w2 }; e- MRating: 5 ! V9 [( t& ?; d g$ i0 f2 J2 m* @( w6 d3 J+ j
Science journalist Ann B. Parson presents The Proteus Effect: Stem Cells And Their Promise For Medicine, a fascinating look at what research into fetal stem cells has to say about not only the latest modern medicine, but also the aging process and the destiny of humanity itself. Going from scientific discoveries in 1740 to the cutting-edge research of the modern day, The Proteus Effect looks at not only issues of research and learning, but also political and social concerns regarding stem cell research and ethical questions of a morally slippery slope. An absolute must-read for anyone seeking to learn more about this controversial research and the new discoveries constantly being gleaned from it. B0 g7 O5 \+ s ?- c3 k
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Summary: Unique treatment of an important subject 3 [/ V9 [6 ^$ T& h8 cRating: 53 v$ Z+ c# Z/ Y1 q/ N! ?2 K
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I have been active in biomedical research advocacy for many years, and in stem cell advocacy for the past four years , and Ann Parson's book is, without a doubt, the best treatment of this subject I have seen yet. Whether you have a science background, are a patient or patient's family member, or just wondered what Ron Reagan was doing at the Democratic convention, you have probably struggled to understand the complexity of stem cell technology. This is a task that has been complicated by all the media "noise" surrounding the field -- the ethical debates, the economic stakes, and the adversarial political climate. 8 t( k. c' L, D ! x. F6 {: s4 ?Ann Parson doesn't ignore these issues, but she cuts through and moves beyond them by doing something no one else has thought of doing: she deconstructs the science of stem cells. She takes us back to 1740, to the very earliest biological inquiry into animal regeneration properties, and then brings us forward in time to the present, stacking up the building blocks of acquired knowledge, experiment by experiment, scientist by scientist, until we find ourselves immersed in the goals and implications of stem cell science. Parson gives us lots of scientific information, but suffuses it with human interest and context, making it eminently readable by people of all backgrounds. If you feel like you have a citizen's obligation to figure out what the debate is all about - from the historical, medical, ethical and political perspectives - this is the book to start with. ' Y0 j5 N1 ^0 R. ]9 U% V % M" P# _+ k: Jhttp://ifile.it/j2k0q79/0309089883.zip作者: telomerase 时间: 2009-4-27 20:33
The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy (Basic Bioethics) ' c( y; A3 s7 ?4 l) q) D( W' a
6 q, l3 h4 D# b7 s( a% T" oPublisher: The MIT Press - I. f @, b% o" n
Number Of Pages: 288 ) O1 G4 n- u% G0 U5 W5 U1 d% _( kPublication Date: 2001-09-01 & B& ^" d- G/ _8 A: T0 [ISBN-10 / ASIN: 0262582082 + W6 ]5 I$ p0 w1 u! W5 b& [ISBN-13 / EAN: 9780262582087 * }* H5 w3 y$ W* g( T. E: N
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Product Description: ) l5 @0 v: T, V4 h5 K/ G
8 y$ Q2 g) D0 @9 y, g( rHuman embryonic stem cells can divide indefinitely and have the potential to develop into many types of tissue. Research on these cells is essential to one of the most intriguing medical frontiers, regenerative medicine. It also raises a host of difficult ethical issues and has sparked great public interest and controversy. This book offers a foundation for thinking about the many issues involved in human embryonic stem cell research. It considers questions about the nature of human life, the limits of intervention into human cells and tissues, and the meaning of our corporeal existence. The fact that stem cells may be derived from living embryos that are destroyed in the process or from aborted fetuses ties the discussion of stem cell research to the ongoing debates on abortion. In addition to these issues, the essays in the book touch on broader questions such as who should approve controversial research and what constitutes human dignity, respect, and justice. The book contains contributions from the Ethics Advisory Board of the Geron Coroporation; excerpts from expert testimony given before the National Bioethics Advisory Commission, which helped shape recent National Institutes of Health policy; and original analytical essays on the implications of this research.; p& T" T( D1 H0 e8 a
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Summary: Bought for a class, but pretty interesting- F+ A8 D& l. t- n: k
Rating: 4 + E+ K7 j }. [9 K7 h2 V- L+ y3 a: ]! O' z6 d% ]7 i
I bought this book for a class, but it's pretty interesting anyway. The Catholic viewpoints in here are a bit... unrepresentative, though. The Jewish viewpoints were very enlightening.9 F0 q9 W! Y- F3 z( B0 R6 o
* t. Y0 f$ y' }* r8 J" N! ]$ T+ Z . R5 d$ {. H7 [( d, f 7 D1 z! m# d+ ~/ u; {; uSummary: It's a start, but where's the debate? , ?9 \8 }9 L4 V. J* KRating: 3, H7 G: |/ y7 s$ N) E( q
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Holland et al. created a good introduction to the public policy and science behind the current embryonic stem cell research (ESCR) debate, but while this book has "debate" in its title, there was little material disagreement between most of the contributors. A more robust, representative exchange of ideas would have made this book 5-star material. , x5 D3 w' a( C' w, e) f0 \! i7 G8 {2 {2 G/ ? o( O, u" i& k0 w
The book is divided into several themes.The first three chapters are on the basic science and history of stem cell research, and the editors' choice of contributors is impeccable: they include James Thomson, who first isolated human embryonic stem cells, and Thomas Okarma, president and CEO of Geron Corp., which is the private firm that has spearheaded the development of Thomson's discoveries. ; s- O2 d8 }" Q* T4 L 1 F- W3 A' `$ X6 w# B3 U3 TThe second section segues from history to public policy and ethics, including analyses of the National Bioethics Advisory Committee's report on stem cells in 1999. This by and large was a good introduction to how the government, and specifically the Clinton administration, began to respond to stem cells. Erik Parens has a good article on how people tried to differentiate between the morality of experimenting on embryos from IVF clinics and embryos made specifically for research, and a few other dilemmas stemming from current human embryonic stem cell (hES) sources and protocols.! _; q' i0 ~& N
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We then go into the third section, which contains religious perspectives on ESCR. This is where I found the term "debate" a misnomer, as for the exception of Gilbert Meilaender, a Protestant thelogian, all the religious commentators tried to show how their traditions could tolerate, if not actively approve of, ESCR. Now I know that many religious people approve of ESCR, but the deafening silence on the opposition's part (excepting Dr. Meilaender's rather short piece) concerns me. Ironically, in the following section, sociologists Paul Root Wolpe and Glenn McGee note that the majority of the ESCR dialogue has been within a scientific community with an active interest in promoting ESCR. This seems to be just the case in this book. " k) Y+ L$ T6 P7 X) U0 d1 X8 v) ?' |9 _( a& {, \
The fourth chapter is a public policy section, with the aforementioned good essay by Wolpe and McGee on the nature of the ESCR debate. The essays treat issues like whether pressure will be exerted on women in fertility clinics to donate unused embryos to labs, whether the poor will get stem cell therapy, government oversight, and several other practical concerns that must be addressed if one promotes ESCR and any future applications it may bring. A few essays bear particular note: throughout the debates on ESCR in past three years 1999, I didn't hear much of the minority or feminist viewpoint on ESCR, so the opinions of Suzanne Holland (who appears earlier in Section II), Margaret McLean, and Cynthia Cohen were particularly handy. Thomas Shannon had some good points about whether the ESCR funding would deprive people of more basi public health programs.3 G" o! B/ r) s8 K1 m
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On the whole, this is a useful book, but I suggest that in addition to reading the thoughts in this volume, you should check out Richard Doerflinger, the research ethics group Do No Harm or some of the others who oppose embryonic research. If this book were to do justice to both sides, it would be a truly first-class resource. , K! ]3 |& V0 j/ ^4 `: H/ o7 O! q# y) H
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Summary: It's a start, but where's the debate?6 t: E% B$ B/ n3 ?( i% E P8 W
Rating: 34 q& a' m5 G$ M
0 N- M1 t5 F: l" zHolland et al. created a good introduction to the public policy and science behind the current embryonic stem cell research (ESCR) debate, but while this book has "debate" in its title, there was little material disagreement between most of the contributors. A more robust, representative exchange of ideas would have made this book 5-star material. ) q, a$ n1 i* \* K% b+ D1 [ + `' ?5 i* t, Q' Q8 \The book is divided into several themes.The first three chapters are on the basic science and history of stem cell research, and the editors' choice of contributors is impeccable: they include James Thomson, who first isolated human embryonic stem cells, and Thomas Okarma, president and CEO of Geron Corp., which is the private firm that has spearheaded the development of Thomson's discoveries. : B5 _) X4 b9 \$ W! x! C7 J/ s 5 c+ O3 Z3 P) l* y! D/ z* WThe second section segues from history to public policy and ethics, including analyses of the National Bioethics Advisory Committee's report on stem cells in 1999. This by and large was a good introduction to how the government, and specifically the Clinton administration, began to respond to stem cells. Erik Parens has a good article on how people tried to differentiate between the morality of experimenting on embryos from IVF clinics and embryos made specifically for research, and a few other dilemmas stemming from current human embryonic stem cell (hES) sources and protocols. ; r6 n8 J4 `2 b, n& I7 ?4 W9 ?7 [( `5 G- f" j8 I- n! J
We then go into the third section, which contains religious perspectives on ESCR. This is where I found the term "debate" a misnomer, as for the exception of Gilbert Meilaender, a Protestant thelogian, all the religious commentators tried to show how their traditions could tolerate, if not actively approve of, ESCR. Now I know that many religious people approve of ESCR, but the deafening silence on the opposition's part (excepting Dr. Meilaender's rather short piece) concerns me. Ironically, in the following section, sociologists Paul Root Wolpe and Glenn McGee note that the majority of the ESCR dialogue has been within a community with an active interest in promoting ESCR. This seems to be just the case in this book. 1 n) e5 E c7 V: R # {2 e8 A) n1 m7 V; J/ QThe fourth chapter is a public policy section, with the aforementioned good essay by Wolpe and McGee on the nature of the ESCR debate. The essays treat issues like whether pressure will be exerted on women in fertility clinics to donate unused embryos to labs, whether the poor will get stem cell therapy, government oversight, and several other practical concerns that must be addressed if one promotes ESCR and any future applications it may bring. During the height of the ESCR debate, I didn't hear much of the minority or feminist viewpoint on ESCR, so the opinions of Suzanne Holland (who appears earlier in Section II), Margaret McLean, and Cynthia Cohen were particularly handy. R1 r& x4 p' M% b) Z! M8 \
/ @7 E% Y6 b! Y1 m- eOn the whole, this is a useful book, but I suggest that in addition to reading the thoughts in this volume, you should check out Richard Doerflinger, the research ethics group Do No Harm or some of the others who oppose embryonic research. If this book were to do justice to both sides, it would be a much better resource.2 k% @/ ]* h4 O# i) r4 A
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( [4 `; o Z. S( d2 g d - C4 \; h `- R# g! ~- m; @; gSummary: Must read on timely issue* }. ^' m- N! v; b2 j
Rating: 51 |; k- g" f9 a& j
; V7 Z; A# _1 @3 ~Stem cells- the leading newspaper topic before the September 11 horrors and a topic to which we are of necessity returning. This book is an amazingly readable compilation of information on the science, the positions. the impact of the research (or failure to do the research),and the pros and cons of regulation. In a time when not only the government's but also the public's views on this issue are in a constant state of review, these editors have managed to pull together a collection that will not become a stale item, even though addressing a "hot" topic. The selections are ones that someone without medical or research scientist training can readily understand, yet not simplistic to the extent of ever bordering on boring. Truly a must read. . B4 l% u; q% k& l0 E3 H l8 I5 T+ T7 u- B
7 d) P* D/ C, k4 \+ V - _( u) t( g! l4 d' M5 TWith the incredible potential of gene transfer into hematopoietic stem cells, active research in this field has become critically important. In "Genetic Modification of Hematopoietic Stem Cells: Methods and Protocols", leading scientists in the field provide a compendium of protocols which cover the subject comprehensively, from the purification and culture of various types of hematopoietic cells for subsequent genetic modification by vector development and technical issues of small and large scale vector production, to the complex issue of monitoring and biosafety studies related to gene-modified hematopoiesis. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections, which allow the experts to highlight tips on troubleshooting and avoiding known pitfalls.6 J% i: f8 a- m( J* |
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Unique and cutting-edge, "Genetic Modification of Hematopoietic Stem Cells: Methods and Protocols" is an ideal, thorough resource to promote further research and the implementation of investigator-driven clinical studies using gene-modified hematopoietic cells.9 [- X6 c- k; F- [7 D
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O0 F! Q; a* f( J! y* i3 c http://ifile.it/irhdfjg/hep.rar作者: telomerase 时间: 2009-4-27 20:34
Stem Cells in Regenerative Medicine: Methods and Protocols (Methods in Molecular Biology, 482) 0 W$ L; i# s6 Y1 A' R7 C0 T
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By Julie Audet, William L. Stanford1 }9 H0 O9 y& M+ k) a
5 `6 k% O# b7 h- w: g . W# g! c0 S; T. W5 Y ! q. G+ a- T& E2 RPublisher: Humana Press # l; p' ?6 |- p9 W- H
Number Of Pages: 367 % \& F( g; H, }' Y6 [" N
Publication Date: 2008-12-12 5 y: d6 D0 v: T6 Z
ISBN-10 / ASIN: 1588297977 6 d/ _: d* I1 @( \1 ?
ISBN-13 / EAN: 9781588297976 & V( m7 |. j$ y7 Y- V
Binding: Hardcover - h/ X- j3 U# w2 W
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1 ?1 C% E$ V9 f" l' }! S. R q4 S7 |9 g: o8 [3 E8 x" Z8 oAs regenerative medicine involves replacing diseased cells, tissues or organs, or repairing tissues in vivo, the manipulation of stem cells underlie its goals. In Stem Cells in Regenerative Medicine: Methods and Protocols, leading experts in the field provide an updated representation of the landscape of stem cell-based therapies in a wide spectrum of tissue systems and ontogenic stages, from the isolation and culture of stem cells to their actual use in vivo. Written in the highly successful Methods in Molecular Biology™ series format, these chapters include brief introductions to the topic, lists of the necessary materials and reagents, readily reproducible, step-by-step laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. $ X* \" h: R0 Q/ r$ e3 S3 _ 1 ~5 ^2 p# V$ ]$ R% WComprehensive and easy-to-use, Stem Cells in Regenerative Medicine: Methods and Protocols is certain to contribute greatly to the definition of standardized procedures for the manipulation of somatic and embryonic stem cells in research and clinical applications.% e& q% |$ H( q& C" l& n