, q* K; R5 V- BToday' s topic: Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy + T: s# W* O$ o5 x; A& { 3 s! ^, k; A$ F3 z5 o, HThe summary and the paper is in the attachments.1 Y3 s% P" R& D' ^- t8 A4 S4 \
1 you could try to translate the summary9 T4 b4 {3 v. F) {% c( ~: A. C6 e* G
2 you could talk about the author or the institute & V3 A- M$ W- f1 o. x6 g3 you could summarize steps of the experiment or the results ; b# m& @* _3 D5 p. B [+ y( \- h7 v4 you could give your doubts of this paper " T5 l$ }( Q! f1 K. y5 you could upload your record of the summarize 5 K K% Y+ i5 Q/ b3 ^9 E9 p6 \- w$ e4 L' I( b: ?/ H3 p2 ~" |, i$ ~0 h
If you want to talk something else, please let me know.作者: linxingxing 时间: 2009-9-6 01:13
Luigi Naldini % _! T: I* f) x3 @' V" D; JGene Transfer Technologies and new Gene Therapy Strategies: R2 J2 ~* ]* ?' ` luigi.naldini@hsr.it 7 |# p/ Y6 ?9 w5 x
) `& G' }7 E, v+ G+ d. P# u* ~2 Q 9 U1 o& q: }4 tSomatic gene therapy requires the efficient delivery and sustained expression of therapeutic genes into the tissues of a human body. Such an approach has tremendous therapeutic potential for several inherited and acquired diseases. However, several challenges must be met to fulfill these expectations, starting from the development of more efficient, safe and versatile gene transfer tools.作者: linxingxing 时间: 2009-9-6 15:12
introduction % h( s+ Q, S, a0 I7 ydesign of lentiviral vectors! K3 Q( D, L+ H; {( ?
transgen expression by lentiviral vectors7 G; H% Y, m: e. M9 N6 O
biosafty of lentiviral vectors % |6 i- _8 d' i6 }. }non-primate lentiviral vectors% J( M) f& f+ g/ D, C( j0 n) q
gene transfer performance+ f( v& @) a$ m/ G3 k) r! h8 H
conclusions and perspectives- s. \( ?! E+ F' h
reference作者: linxingxing 时间: 2009-9-6 15:12
introduction - J+ k' G& g- s. Ndesign of lentiviral vectors0 c8 ~- \% }! j: w* K+ G
transgen expression by lentiviral vectors ; ^& X( T Z4 Q9 f% Wbiosafty of lentiviral vectors% E/ A4 n9 g2 |+ s6 }7 G
non-primate lentiviral vectors- x6 s5 z/ m0 E8 e
gene transfer performance ]( ^. b8 w+ i, \conclusions and perspectives7 `) I" k9 W; q% C! @* l e
reference作者: linxingxing 时间: 2009-9-9 10:32
QUSETION:/ o) X3 @7 x! C. E: K7 A
1 What' s the differences between primate lentiviral vector and nonprimate lentiviral vector?what are they? ) y6 ~+ o( a H% r7 G2 shall we use lentiviral vector in vivo?作者: windboat 时间: 2009-9-10 09:08
楼主辛苦作者: linxingxing 时间: 2009-9-10 20:09
please join in actively, you can learn a lot.作者: angel-sakura 时间: 2009-9-10 22:57
来学习下~~~作者: pig 时间: 2009-9-12 00:48
come on~作者: linxingxing 时间: 2009-9-12 16:40
"HIV can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Some of the subtypes are known to be more virulent or are resistant to different medications. Likewise, HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses, although HIV-2 is known to cause AIDS." & f; m; l& {: p4 {" M. w! I5 s ! s5 V3 g3 O; R( M& x7 Aso primate and nonprimate lentiviral vector are different origins. they used for different hosts.作者: peter1983 时间: 2009-10-9 02:15
come on~