本帖最后由 细胞海洋 于 2009-11-9 08:23 编辑 9 a3 s2 e1 R* j$ P; q9 P/ P
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Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog, OCT4 and SOX2 pluripotency transcription factors with Polycomb Repressive Complexes and Stem Cell micro-RNAs. ! e1 D, C: `9 _2 i" _+ S! Q: S ( T: L( ^ {5 e1 gRegulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog, OCT4 and SOX2 pluripotency transcription factors with Polycomb Repressive Complexes and Stem Cell micro-RNAs.2 y! t5 G: K. Q: }
" P2 T- F& f+ g6 v bStem Cells Dev. 2009 May 29; 7 T+ @0 ]: x! v0 @/ g; z! u' ]5 |; e, {$ s! W$ t
Authors: Kashyap V, Rezende NC, Scotland KB, Shaffer SM, Persson JL, Gudas LJ, Mongan NP% b% P" W7 O+ M) s0 A% x
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Coordinated transcription-factor networks have emerged as the master regulatory mechanisms of stem cell pluripotency and differentiation. Many stem cell specific transcription factors, including the pluripotency transcription factors, OCT4, Nanog and SOX2 function in combinatorial complexes to regulate the expression of loci which are involved in ES pluripotency and cellular differentiation. This review will address how these pathways form a reciprocal regulatory circuit whereby the equilibrium between stem cell self renewal, proliferation and differentiation is in perpetual balance. We will discuss how distinct epigenetic repressive pathways involving polycomb complexes, DNA methylation, and microRNAs cooperate to reduce transcriptional noise and to prevent stochastic and aberrant induction of differentiation. We will provide a brief overview of how these networks cooperate to modulate differentiation along hematopoietic and neuronal lineages. Finally, we will describe how aberrant functioning of components of the stem cell regulatory network may contribute to malignant transformation of adult stem cells and the establishment of a "cancer stem cell" phenotype and thereby underlie multiple types of human malignancies. . ^+ X7 ~- S! Z8 n" s+ b2 @) ] 8 R6 i. J- g; P* g) m3楼原文 感谢ydj19830 提供作者: 张也行 时间: 2009-11-8 23:31
很感兴趣，LZ有原文吗？谢谢了作者: ydj19830 时间: 2009-11-9 01:49
原文作者: gaoyunhezuibang 时间: 2009-11-9 10:06
xiexie作者: 微微一笑 时间: 2009-11-9 14:46
非常感谢！作者: stemcell313 时间: 2009-11-11 08:48
thanks作者: chb611301 时间: 2009-11-11 09:56
THANKS FOR SHARING作者: oldmac7 时间: 2009-11-14 09:21
看看如何..作者: askage 时间: 2009-11-14 17:50
十分非常感谢作者: sailan 时间: 2009-11-16 15:50
谢谢分享！！！作者: limoping 时间: 2009-11-16 18:20
非常支持作者: jessica.jr 时间: 2009-11-28 22:53
谢谢啦作者: 胡问成 时间: 2009-12-2 23:55
回复 1#托斯卡纳教父 , ]! H$ G! U) T1 s, T8 d2 |( y G0 F& o" Q( R7 h/ x
