回顾p53的发现和认识史，作者感慨：When a group believes something, evidence to the contrary tends to be more readily dismissed. " r8 y( X* q) I我们目前从事的热门学科是否也存在这种问题呢！作者: iseeyou1210 时间: 2009-11-11 00:41
谢谢！作者: 张也行 时间: 2009-11-11 12:33
呐也是 谢谢哈作者: have-a-rest 时间: 2009-11-11 21:34
30 years and a long way into p53 research+ A2 g; D( P$ K+ \0 M
Pierre Hainaut, Klas G Wiman! b; j- K3 ~+ c+ ]% Q
Among the 278 092 publications indexed into PubMed in 1979, a handful of articles stand out as the foundation of one8 n. }- u, J7 A
of the most profound forays into the molecular basis of carcinogenesis: the discovery of the p53 tumour-suppressor ' _4 }; `" N7 y" @5 {protein. In the 30 years since then, understanding of p53 has progressed from obscure oncogene to key- \% N* F, B8 X$ c* }# y6 n4 E
tumour-suppressor gene with clinical potential. Yet, p53 research has not followed a straight course. In this Historical # X" s5 g k) Y0 x8 k, aReview, we describe how the 1979 discovery has shaped our view of the molecular basis of cancer, and identify some1 J% n, [$ U2 v1 c
crucial steps ahead to transfer the wealth of knowledge accumulated on p53 into applications to cancer prevention2 ?* G2 ?) s$ g$ p
and treatment. ( {! [6 T. g4 k* E* m/ U% [1 Y- F[attach]2936[/attach]作者: franklinhg 时间: 2009-11-25 00:43