干细胞之家 - 中国干细胞行业门户第一站

标题: 干细胞衰老以及逆转 [打印本页]

作者: nanocellmatrix 时间: 2010-4-24 20:13 标题: 干细胞衰老以及逆转

本帖最后由 nanocellmatrix 于 2010-4-24 20:17 编辑 $ E' Q0 g! h( `1 a

Harvard 的科学家证实将衰老的造血干细胞培养于年轻的Niche中，衰老的干细胞命运可以逆转。
对于这个问题的解答：不外乎stem cell intrinsic alterations 或 age-related changes in the stem cell supportive microenvironment/ niche.
研究发现，这种现象与niche细胞应答有关，同时与局部微环境中IGF的调节有关。

希望大家可以关于干细胞命运的逆转（ips，衰老，转分化等）探讨。: w$ q1 F: i4 i+ R- H6 c4 z0 s

Systemic signals regulate ageing and rejuvenation of blood stem cell niches
Shane R. Mayack, Jennifer L. Shadrach, Francis S. Kim & Amy J. Wagers$ w! S, J/ v; B3 O' R8 N
Department of Stem Cell and Regenerative Biology, Harvard University, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02115, USA.6 l# ]$ S# M3 Q/ L

Ageing in multicellular organisms typically involves a progressive decline in cell replacement and repair processes, resulting in several physiological deficiencies, including inefficient muscle repair, reduced bone mass, and dysregulation of blood formation (haematopoiesis). Although defects in tissue-resident stem cells clearly contribute to these phenotypes, it is unclear to what extent they reflect stem cell intrinsic alterations or age-related changes in the stem cell supportive
microenvironment, or niche. Here, using complementary in vivo and in vitro heterochronic models, we show that age-associated changes in stem cell supportive niche cells deregulate normal haematopoiesis by causing haematopoietic stem cell dysfunction. Furthermore, we find that age-dependent defects in niche cells are systemically regulated and can be reversed by exposure to a young circulation or by neutralization of the conserved longevity regulator, insulin-like growth factor-1, in the marrow microenvironment. Together, these results show a new and critical role for local and systemic factors in signalling age-related haematopoietic decline, and highlight a new model in which blood-borne factors in aged animals act through local niche cells to induce age-dependent disruption of stem cell function.

附件: nature08749-s1.pdf (2010-4-24 20:10, 425.97 KB) / 下载次数 98
http://www.stemcell8.cn/forum.php?mod=attachment&aid=NjY0N3xhNDk5ODBjMnwxNzkzNzAwODU1fDA%3D

附件: nature08749.pdf (2010-4-24 20:14, 704.85 KB) / 下载次数 115
http://www.stemcell8.cn/forum.php?mod=attachment&aid=NjY1MHwwYzc3ZWFhOXwxNzkzNzAwODU1fDA%3D

作者: Aaron_Suen 时间: 2010-4-24 20:22

学习了，谢谢啊～

作者: angel-sakura 时间: 2010-4-24 21:49

好东西啊！！我正好在研究这方面的。

作者: wjy1597 时间: 2010-4-25 14:46

谢谢正在读

作者: meng19821013 时间: 2010-4-25 15:29

thank you so much

作者: bypw 时间: 2010-5-17 17:54

学习了

作者: qoome2003 时间: 2010-10-26 23:02

这篇文章被撤回了——retracted.

nature08749.pdf (449 KB) 1 o' U5 d9 R6 b E6 I
nature news

附件: nature08749.pdf (2010-10-26 23:00, 449 KB) / 下载次数 24
http://www.stemcell8.cn/forum.php?mod=attachment&aid=MTU4NTB8NDJkNjYwZTR8MTc5MzcwMDg1NXww

欢迎光临干细胞之家 - 中国干细胞行业门户第一站 (http://www.stemcell8.cn/)