REVIEW 9 x9 Y" k5 ^/ \* q. W+ }Cardiogenesis and the Complex : Q& @$ K4 [' RBiology of Regenerative . t! s! s. m5 TCardiovascular Medicine) |% d* j+ t5 m. m$ _1 w
Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3/ p1 Z- |' s4 S C
The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle . s: V; U. _% _7 p5 G) A+ J0 b) j# Wcells. Understanding the pathways that drive the formation, migration, and assembly of these cells , f0 o8 ]! S/ q8 q3 n" uinto the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is ) {* W# t) F# _a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo+ P2 k; x- W- O
cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These# W4 L9 Y2 W! a; a7 J6 h
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and3 Q ]6 W/ v4 T* c. u' I8 X2 z( ?
ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering 4 d' D0 e) ?3 D/ [$ V4 k! Gtechnologies with patient-specific cardiac progenitor biology holds great promise for the ! t" P5 K. f' d6 {development of human cell models of human disease and may lay the foundation for ) M W" c1 y: x. f! onovel approaches in regenerative cardiovascular medicine.作者: jianlindunev 时间: 2010-5-6 21:35
