Tbx18 and the fate of epicardial progenitors- t9 f% V; z" e. H3 V
Arising from: C.-L. Cai et al. Nature 454, 104–108 (2008) 3 ]$ K8 ~- Z* q9 ]Uncovering the origins of myocardial cells is important for understanding 0 A9 M/ f! T% v- rand treating heart diseases1,2. Cai et al.3 suggest that Tbx18- c% b9 z+ P8 T( \% ~. m
expressing epicardiumprovides a substantial contribution tomyocytes ; e! C( T, I2 C* {/ Rin the ventricular septum and the atrial and ventricular walls. Here we % t$ b) _7 d1 P1 S+ _show that the T-box transcription factor gene 18 (Tbx18) itself is) z: g# v* o* K6 L9 B- Q1 W
expressed in the myocardium, showing that their genetic lineage - @5 h6 L6 B* m ^/ {5 ptracing system does not allow conclusions of an epicardial origin of - r \! J# S7 kcardiomyocytes in vivo to be drawn.作者: jianlindunev 时间: 2010-5-6 23:29