本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑 ) Z% e' A* _( t+ } " L0 l- R5 n8 J3 X2 R" Q6 Q* @, [9 \李凌松*，王 莉; |# h" d5 d- {
（北京大学干细胞研究中心细胞生物学系，北京 100871） 8 I6 i8 ~; z, W1 {摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学 8 l4 j3 }! J* l' a. R特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界% `* D: Q1 E/ I- J4 G
范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日 0 Y! _) |2 {0 p2 t起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身( |& @, p; y+ C+ i4 Z# E. X4 w
涉及的伦理学争论给予概述。8 Y% W6 m; e) ]8 b
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用 7 W( y( X6 K2 M$ ]1 L8 y% J. Z中图分类号：Q813 文献标识码：A 9 E# x; e: u, d# z, | h- REmbryonic stem cells! M3 G0 R# E# T! z& l
LI Ling-Song*, WANG Li0 Y2 \% O! I3 ]# R+ z8 m3 T
(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871): j7 h+ G' L) A, P3 r+ a
Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to ( }4 g2 n( E3 N3 N. otheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental+ d+ O3 X6 f0 n0 d3 k) M* J+ Y
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation , P8 g& C2 U% X1 _9 {$ N# ceggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial. : |; u/ e7 ~; N9 d' @: X6 C0 U* _2 nThis review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell ! G' H: q: F6 min treating diseases, as well as ethical issues related to human ES cells research.- h/ |% w3 ^# P5 d
Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;5 l/ u. {) I& S$ i" J& H+ Q
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