摘要 % k$ P0 q, A: x( w5 d9 f7 RIn 2006, it was reported that transgenic expression of merely + e- w5 _! {6 @four defined transcription factors (c-Myc, Klf4, Oct4, and Sox2) 0 v# q/ f! U% t% Lis sufficient to reprogram somatic cells to a pluripotent state.) l+ v- y# x9 \* q
The resulting induced pluripotent stem (iPS) cells ignited 5 b8 Q# J+ t+ }intense interest in the field of life science for their promising # w' Q& l( x/ g4 gapplications in basic biology, drug development, and transplan-7 h( V* w' u/ o& l" {' h0 i
tation. However, the underlying problems of iPS cells seem to 5 q0 K( e4 o8 c2 D: _be ignored. This review shed light on the problems pertaining " E8 j N/ `" G$ k/ ~" siPS cells, including the elusive origin, risk of tumorgenesis, and P+ w5 C& h" S. D' B1 C% k! y
its relationship with natural selection. 2010 IUBMB作者: tainlangxing 时间: 2010-7-10 14:52