Nature Reviews Immunology 9, 28–38 (1 January 2009) ! N: ?6 U& h7 V+ S
S0 M- s N+ O2 u* g Harnessing invariant NKT cells in vaccination strategies 3 w) W' `; \ g- h7 ~4 j/ s2 } , D7 N/ C5 Q$ hVincenzo Cerundolo , Jonathan D. Silk , S. Hajar Masri & Mariolina Salio ' N) x' f9 e% w0 s; K/ N- y 7 N( A. p* I# }8 v1 pAbstract% t5 B' S1 |$ ]" V+ a/ x( a1 d
To optimize vaccination strategies, it is important to use protocols that can 'jump-start' immune responses by harnessing cells of the innate immune system to assist the expansion of antigen-specific B and T cells. In this Review, we discuss the evidence indicating that invariant natural killer T (iNKT) cells can positively modulate dendritic cells and B cells, and that their pharmacological activation in the presence of antigenic proteins can enhance antigen-specific B- and T-cell responses. In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants.作者: tonley 时间: 2010-11-6 11:16