干细胞之家 - 中国干细胞行业门户第一站
标题:
婴幼儿牙齿可能成为新的干细胞来源
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作者:
韩雪娜
时间:
2008-12-30 23:39
标题:
婴幼儿牙齿可能成为新的干细胞来源
日期: 2003-04-23 今日/总浏览: 1/460
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Yourseven-year-old'sbabytoothmaybeworthalotmorethanthequarterthetoothfairyleftunderthepillow.Scientistshavediscoveredthatthepulpinsidedeciduousteethisatreasuretroveoffast-growingstemcells.Naturally-shedchopperscouldthusprovideaneasilyaccessiblenewsourceofthesesought-aftercellsforclinicalstudiesofstem-celltransplantationandtissueengineering.
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Whenhissix-year-olddaughterpulledoutherbabytooth,SongtaoShioftheNationalInstituteofDentalandCraniofacialResearchinBethesda,Md.,washeditofftoprepareitforthetoothfairy.Holdinghisdaughter'spartialtooth,thestemcellresearchernoticedlivingtissueinsideandwonderedwhetheritmightcontainrelativelyyoungstemcells.Shitookthetoothtohislabandfoundthathewasindeedabletoisolatesuchcellsfromthetoothpulpleftinthecrown.
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Extractingmorestemcellsfromthelostbabyteethofseven-andeight-year-olds,ShicalledthenewgroupofcellsSHED(stemcellsfromhumanexfoliateddeciduousteeth).Inthelab,theculturedcellsgrewquickly,formingsphere-likeclustersindicativeofafastrateofproliferationnotobservedinstemcellsisolatedfrombonemarroworadultteeth.Notonlydidtheygrowrapidly,butwhenimplantedundertheskinofimmunocompromisedmice,SHEDinducedboneformation--afeatthatstemcellsextractedfromadultwisdomteethcouldnotaccomplish.SHEDcellsalsotriggeredneuralcellformationinthebrainandfatcellgrowth;stemcellsfromadultteeth,ontheotherhand,arenotasgoodatneuralcellgenerationandcannottriggerfatcellgrowthatall.AreportdescribingthesefindingswaspublishedonlinethisweekbytheProceedingsoftheNationalAcademyofSciences.
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Oneofthechallengesofstemcellresearchisthatnobodyquiteknowstheextenttowhichtheycanbeusedtoinducegrowthintissuesotherthanthatfromwhichtheywereextracted.Inthatregard,SHEDcellscouldpotentiallyworkbetterthanothertypesofstemcellsbecauseoftheiryouth(andthusfastproliferation)andtheirdemonstratedabilitytoinducethegrowthofseveraltypesofcells.Whenkids'teethfalloutwecansavethem,Shiremarks.Iftheyneed[thestemcellsfrom]themin20years,therewillbenoimmunorejection.Justwhatthoseneedsmightbe,Shicannotsay.Butconsideringthatotherresearchersarealreadyfreezingstemcellsfromumbilicalcords,hemuses,Whydon'twesavethisone?
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作者:
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来源: Scientific American
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发布者: 亦云
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