[attach]18326[/attach] * c$ @4 T0 e g$ e3 |1 V英文稿件：& E3 o5 h0 l$ m" v k7 r
A young marmoset is carried by its father at the Amneville zoo, eastern France, June 2010. Japanese researchers said Wednesday they had used stem cells to restore partial mobility in a small marmoset that had been paralysed from the neck down by a spinal injury.8 ]6 t8 a8 X& x( c- e
- C% M. T9 E v6 C8 W B, aJapanese researchers said Wednesday they had used stem cells to restore partial mobility in a small monkey that had been paralysed from the neck down by a spinal injury. 5 E$ t% d1 g) n/ G" ~' K4 a
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"It is the world's first case in which a small-size primate recovered from a spinal injury using stem cells," professor Hideyuki Okano of Tokyo's Keio University told AFP. ; y, k: x z a6 T2 Q, K7 W. P4 X4 S) u- A( o2 G
Okano's research team, which earlier helped a mouse recover its mobility in a similar treatment, injected so-called induced pluripotent stem (iPS) cells into a paralysed marmoset, he said. 6 ^- j) {6 h, E, o# L- y( J( x1 d$ o) R( F
The team planted four types of genes into human skin cells to create the iPS cells, according to Kyodo News. & X) ^* v) Z- Y( `. p% I+ Y$ P1 C8 x" o: F2 T" K j: Q7 G4 b7 E
The injection was given on the ninth day after the injury, considered the most effective timing, and the monkey started to move its limbs again within two to three weeks, Okano said. 9 u; A& b( W& q$ y1 U - O- X2 z- |: e9 L. c: D"After six weeks, the animal had recovered to the level where it was jumping around," he told AFP. "It was very close to the normal level."$ I. @" S7 U! [5 ]- A$ o) g
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"Its gripping strength on the forefeet also recovered to up to 80 percent."9 y' X# |& m. h6 X
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Okano called the research project a major stride to pave the way for a similar medical technique to be used on humans.: s6 G$ b* b& k7 _
: f! Q- U: l- i6 u; v5 mScientists say the use of human embryonic stem cells as a treatment for cancer and other diseases holds great promise, but the process has drawn fire from religious conservatives and others who oppose it.! _- x/ X: }5 y4 }# V: B; ]
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Embryonic stem cell research is controversial because human embryos are destroyed in order to obtain the cells capable of developing into almost every tissue of the body.& A! v' b6 Y! s- V- Y1 u+ ?/ l4 ^
日本人 这个实验创新性很大。如果取的是猴子皮肤细胞然后ips，最后治疗了猴子截瘫。其实也可以的。2 h9 K1 w% G) U, i1 c
但是他们用人的皮肤ips，治疗猴子截瘫，却更有意思了 2 l! y, R' V' I2 ]% dThe team planted four types of genes into human skin cells to create the iPS cells, according to Kyodo News. ' q, @1 y$ P, `5 S ' ^. z" k- a' ^( ~The injection was given on the ninth day after the injury, considered the most effective timing, and the monkey started to move its limbs again within two to three weeks, Okano said.; b- }1 P1 i( K0 `& A& E2 y$ f 作者: 千细胞 时间: 2010-12-10 12:36
这里面有几个很实际的问题， 3 v$ g! c5 M8 I/ P6 B1.先切不说ips的安全性问题，如果用患者自身细胞做ips，前面提及的9天的创伤损伤期这个时间太短了； 1 n* T$ j5 l1 d! S! I2.这个损伤的时间能不能有更加延长的时期，有没有损失到一定的时间后就不可能再恢复了；2 D2 T/ N6 N% B2 Z
3.会不会用诱导后的神经细胞或者神经前体细胞效果会更加好； # D0 t. G+ w5 G ' l F, M. ~$ P个人之言，共讨论作者: qingshui1985 时间: 2010-12-10 13:13
本帖最后由 qingshui1985 于 2010-12-10 13:22 编辑 0 Y8 @# J1 {! ]& P( Z6 B' W! [- s- q8 r 回复 千细胞 的帖子 K* ?* X X' Z. Y, ]( d: \
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回复： ) b5 Z6 I0 A! r6 b$ h9 e3 g1.按照新闻里说法，ips可以用人的治疗猴子的高位截瘫。也就是说供体材料限制小（排除安全性）。没有必要用猴子的皮肤去ips（需要数周），为节约时间，可以拿别的哺乳类的材料如已经诱导好的ips细胞来用。$ d" I: T. x* V' l7 `; ?6 i
7 y" S; i: e6 V' w2.3 这两个问题涉及再生问题。高等动物 蝾螈再生机制较多。但是哺乳类再生机制不明朗。因为再生一个器官所涉及的组织太多，如血管、肌肉、上皮、神经等。而成体体细胞内不存在能生成这么多组织的多能干细胞。( r% V5 t" V2 f: C& D
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但我个人感觉，猴子截瘫后，注入了人的上皮来源的ips细胞后，得到治愈，或许与蝾螈再生过程很相似。蝾螈再生时候会由多能干细胞形成胚基，之后再生附肢。7 c3 Z" E- m r$ o8 l# X
而注入了人上皮ips（同样也是多能干细胞）后，猴子脊椎内的伤口可能不是发生了愈合而是形成了与蝾螈的类似的新的胚基。之后产生多能组织，最后完成了再生过程。/ y. ]" N6 K, s; K$ P/ o" D8 I, B, s
当然这只是我个人想法。也不排除您说的用神经干细胞更有针对性，效果更好。 1 L" M1 F, f& a8 z ' ?) Y) I( J" p6 G参考：德科学家发现蝾螈肢体再生原理 或可造福人类 4 `0 }7 D" ~0 A" B5 S1 b2 Mhttp://www.stemcell8.cn/forum.ph ... mp;page=1#pid238417* j* G& u& Z+ i3 c% n) q
“汉诺威医学院的科学家在对美西螈进行了大量实验后发现，当它的一只腿被截断后，它体内的血管会迅速收缩并止血，皮肤细胞会迅速覆盖在伤口上，并形成所谓的胚基。9 m* G, {9 r1 x3 b. S+ d P
