本帖最后由 细胞海洋 于 2011-1-9 21:53 编辑 ! t4 I. k, j# m 3 W; C( U0 {& Y4 T% X$ XProgenitor Cell Therapy for Neurological Injury: Z+ {, @* l$ s8 r
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Severe neurological injury, including traumatic brain injury, spinal cord injury, and 0 V0 c4 g# v S/ Ystroke, can have devastating consequences. There are currently no reparative therapies9 W2 _9 i4 {5 K5 n- w
for neurological injury, with most treatments designed to limit secondary damage., `4 j2 g& N; D" B* T# j' \( ^# N
The idea that exogenous stem and progenitor cells have the potential to. ]1 t2 Z0 \% `
promote a reparative response to injury is now supported by pre-clinical data,5 }: T" C5 E1 u' I' J3 u9 S1 S
prompting early translational studies using progenitor cell therapies. To that end,+ L: v% ]7 h% }8 N2 f- d* Y
this text explores the unique aspects of neurological injury and focuses on the critical 4 E) s! E; x1 m+ t' r z% W) n0 Z4 s0 wtranslational issues of cell delivery: routes of administration, types of progenitor 5 |& ^( s) [( g& ]0 ]) Fcells (alone and/or in combination), timing of delivery, and adjuncts to promote cell6 [* F( q- O/ T3 l( E+ l6 t" w
engraftment/survival/effectiveness. Finally, measuring the effects of transplanted9 O. \* d3 v- N
cells and cell tracking is explored in several chapters. $ T/ I: q. x# M4 I) E4 A, a% j9 f" pEven while compiling this monograph, the paradigms of how cell-based therapeutics - x0 v# z6 |$ h& U) M Saffect neurological injury have been changing. Mechanisms that seemed) e3 w4 z6 B- c ~, f7 F
reasonable and well-supported are being re-examined, and this necessarily drives 8 N5 y2 \( [3 h& ]) T) Y* Ythe movement toward various clinical trial plans. The earliest clinical trials are 1 Z% ?* S* {. ]# O% }% pbeginning, and as this monograph goes to press, Phase 2 studies in TBI and stroke . K4 t! i0 P- o0 d& uwill begin. The developments in the field may ultimately offer realistic hope for 2 F9 r, `9 g9 f2 t' E" U5 Dimprovement in patients with severe injuries, and the work on these vexing problems1 Z' O A9 l) ~' v: v
will be the key to unlocking future treatments. , k) n: y6 N G F6 G, S; o: I% M/ t0 T3 Z 作者: henryjia 时间: 2011-1-10 22:40