本帖最后由 细胞海洋 于 2011-2-9 08:15 编辑 : A# t4 S2 R& i: X' U5 Y: `) F+ \
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最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。 * h- V& Q3 k5 h% D: \Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and2 V B! K) V8 c+ _$ P; a
they can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only! j0 W% e& @3 ]0 f
those interested in the basic mechanisms of development, differentiation, and reprogramming, but" J1 p2 |% s8 u" F- R
also those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did 3 z" J# \0 G1 n+ {9 w! G" J) Wthe stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch# m$ Q9 |# a0 F) T6 p2 N' H
and James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic 3 r$ j; w" V2 C3 w" [stem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation. H* I* n7 Y7 z5 M/ _, P2 w
in vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and 0 o7 n1 r7 V: \4 w3 }- [McCulloch defined the hallmark characteristics of stem cells., D* i, S9 ` n3 o, j
The field of stem cell research has come a long way in 50 years, as we hope will be apparent from this+ }" g7 t2 l. H9 e6 j
year’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of % y, H8 g8 ~7 E/ ~/ {9 Pstem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic + h0 W$ R. [7 K& v' J4 X: [cells can be exploited for cell replacement therapy. We would like to thank the many distinguished0 @+ q5 m t k6 I
experts who contributed their time and efforts as authors and reviewers to make this special issue on 3 o; y \" W1 n9 Q. q6 Q5 C5 m( Z% astem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys, `( A' j7 h! `8 u
the excitement and promise of stem cell research, as we enter a new era of possibility.作者: yusheen 时间: 2011-2-9 00:03