本帖最后由 细胞海洋 于 2011-3-18 15:49 编辑 7 e, S7 R/ K! h! I* H5 u% V
0 c* U' H5 s& C% Q7 \! hCell Transplant. 2010 Aug 18. [Epub ahead of print]6 Q! }* `0 w% O* y x9 H% a
Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis. p% z9 g! `5 O. h2 H$ S
Park JY, Jeon SH, Choung PH. p O9 E2 v( v) P. q. T# BAbstract7 U% B; Q# d/ z5 P5 e# m
Periodontitis is the most common cause for tooth loss in adults and advanced types affect 10% to 15% of adults worldwide. The attempts to save tooth and regenerate the periodontal apparatus including cementum, periodontal ligament and alveolar bone reach to the dental tissue derived stem cell therapy. Although there have been several periodontitis models suggested, the apical involvement of tooth root is especially challenging to be regenerated and dental stem cell therapy for the state has never been investigated. Three kinds of dental tissue derived adult stem cells (aDSCs) were obtained from the extracted immature molars of beagle dogs (n=8), and ex vivo expanded periodontal ligament stem cells (PDLSCs), dental pulp stem cells (DPSCs), and periapical follicular stem cells (PAFSCs) were transplanted into the apical involvement defect. As for the lack of cementum specific markers, anti-human cementum protein 1 (rhCEMP1) antibody was fabricated and the aDSCs and the regenerated tissues were immunostained with anti-CEMP1 antibody. Autologous PDLSCs showed the best regenerating capacity of periodontal ligament, alveolar bone and cementum as well as peripheral nerve and blood vessel which were evaluated by conventional and immune histology, 3D micro CT and clinical index. The rhCEMP1 was expressed strongest in PDLSCs and in the regenerated periodontal ligament space. We suggest here the PDLSCs as the most favorable candidate for the clinical application among the three dental stem cells and can be used for treatment of advanced periodontitis where tooth removal was indicated in the clinical cases.6 ?3 b; o2 d, w8 |8 w9 b' q" ] 作者: qianqianlaile 时间: 2011-3-18 15:25
回复 qianqianlaile 的帖子; d7 |, ^. q: [4 @( U' q& C U
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很有内容的信息，学习了。几点建议：+ n; @( p* H! y: m: [ k/ M
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[Epub ahead of print]Epub 提前打印 ) Y; B9 l, G- Z6 H# }4 Q ' F6 P& }9 ^6 ^7 h9 [) REpub应该是electronic publication电子出版，ahead of print是“付印前”：付印前电子版。9 x# X9 b7 A1 b* x' G1 P
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Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis.牙周膜干细胞移植治疗进行性牙周炎的效果 . Y! P. o5 b; M# p- s+ ^2 }( u% L6 l
advanced = “高级别”，用在疾病分类上是指病程发展比较深的，后期的，晚期的，重度的，一般翻译为“严重的”。“进行性”在医学上一般用progressive，比如progressive muscular dystrophy=进行性肌营养不良。需要指出的是“进行性”有时候在病理上也等于“退行性”，所以有时用degenerative，如neurodegenerative diseases，神经退行性病变。 ! W# S1 Q! I) c$ N: S% l( h: i( b5 W/ y- J+ T
Although there have been several periodontitis models suggested, the apical involvement of tooth root is especially challenging to be regenerated and dental stem cell therapy for the state has never been investigated. 虽然一些牙周炎模型显示，牙根的根尖是再生和牙源性干细胞治疗的特殊挑战，但还有待进一步研究。 ; ~# x% ^2 N0 f9 Q& \ 8 H3 X* D8 V E# h. D/ P2 v“尽管人们提出了几种治疗牙周炎的方法，然而牙根尖的再生极具挑战性，尚未见牙齿干细胞治疗这种病理状况的研究。”the state应该是指前述牙根尖再生问题。* o6 r \1 ]5 ~8 Z
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The rhCEMP1 was expressed strongest in PDLSCs and in the regenerated periodontal ligament space. 抗人牙骨质蛋白-1在牙周膜干细胞中和牙周膜再生期间表达最强。4 E. w( Q( P* o& Q) ~! U `) g
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“……在……和再生的牙周膜间隙（即牙骨质与骨质齿槽的空隙）表达最强。” F% J- w, k( a2 X , c. I( p2 x0 n! G+ Z( gWe suggest here the PDLSCs as the most favorable candidate for the clinical application among the three dental stem cells and can be used for treatment of advanced periodontitis where tooth removal was indicated in the clinical cases.我们的研究表明，三种牙干细胞之中，牙周膜干细胞最有望用于临床，可被用于治疗引起牙齿移位的进行性牙周炎的临床病例。 0 J( I9 t5 Z9 p# `1 M+ N" _& g8 t! K$ B8 ^" G6 ^6 W
“……可用于治疗有拔牙指征的严重牙周炎。”where tooth removal was indicated in the clinical cases是指牙科临床上严重的牙周炎导致必须拔牙的病例。was indicated=提示、暗示等，即有……的指征。 4 V& Q- m* d/ u$ X 2 G, T: f; f: h1 C2 W/ y9 f仅供参考。作者: qianqianlaile 时间: 2011-3-18 22:32
