Annu Rev Biochem. 2007;76:447-80. - \. }6 p1 ^& e( d6 U" @) D' W0 g- S 0 H% T4 x+ P+ `* V) I5 KSignaling pathways downstream of pattern-recognition receptors and their cross talk. ( n5 Z& a( D( G7 x: ?* V( |Lee MS, Kim YJ. + |+ P- L' e; ~/ K5 G3 G5 |( h& A% T8 K& y+ ]
Department of Biochemistry, Yonsei University, Seoul 120-749, Republic of Korea. myeongsup.lee@gmail.com: g) y* c) [6 j4 U, R6 b' g
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Abstract : }7 q7 e; @6 s7 f1 O+ mPattern-recognition receptors (PRRs) initiate innate immunity through pathogen recognition. Serum PRRs opsonize pathogens for enhanced phagocytic clearance. Toll-like receptors (TLRs) initiate common NF-kappaB/AP-1 and distinct IRF3/7 pathways to coordinate innate immunity and to initiate adaptive immunity against diverse pathogens. Cytoplasmic caspase-recruiting domain (CARD) helicases, such as RIG-I/MDA5, mediate antiviral immunity by inducing the production of type I interferons via the adaptor IPS-1, whereas nucleotide-binding oligomerization domain (NOD)-like receptors mediate mainly antibacterial immunity by activating NF-kappaB or inflammasomes. Dectin-1 is important for antifungal immunity, promoting phagocytosis and activating NF-kappaB. Potentially harmful TLR signaling pathways can be negatively regulated by negative feedback mechanisms and also by anti-inflammatory factors such as TGFbeta, interleukin (IL)-10, and steroids. Many combinations of TLR-TLR and TLR-NOD modulate inflammatory responses. TLRs and NALP3 interplay to produce mature IL-1beta. Thus signaling pathways downstream of PRRs and their cross talk control immune responses in effective manners.( h+ T1 Q6 F6 K" |0 x% Z8 g
% l! N2 F) {) N. ^8 V. ~8 D 作者: ada800515 时间: 2011-3-25 21:50