本帖最后由 l19rna 于 2011-4-6 22:31 编辑 ( s& g! e2 [0 O6 ] z" s3 ?3 M+ K' X( l6 G8 }) T
建议你看文献the hallmarks of cancer: the next generation, 里面有详述参与肿瘤形成的各种细胞。附一张截图 + f; L1 D3 u r) V. c5 ^[attach]24537[/attach] - S+ J, W. _+ W; q& U附原文[attach]24539[/attach] $ ?: {3 h% s0 @. U. c(Upper) An assemblage of distinct cell types constitutes $ @: ?) x; |/ `, k5 Vmost solid tumors. Both the parenchyma and stroma of* z& q" E" b/ k/ |+ t1 ^
tumors contain distinct cell types and subtypes that ' q* c' P" a7 r" e! ycollectively enable tumor growth and progression.' K2 T" E: W4 F3 {, v
Notably, the immune inflammatory cells present in tumors 2 t) J; V( i4 T6 V y" Ncan include both tumor-promoting as well as tumor-killing % ~7 Q8 N) ^5 @* {! o4 asubclasses. # V j% x4 _ `; B(Lower) The distinctive microenvironments of tumors. The/ q5 c+ y& Q8 h A4 x
multiple stromal cell types create a succession of tumor * e8 q( ~+ M t S1 B9 [6 l7 w2 _microenvironments that change as tumors invade normal : s) Q. Q/ `2 Rtissue and thereafter seed and colonize distant tissues./ T/ x' A/ a4 i
The abundance, histologic organization, and phenotypic # O$ S8 p a' B# a( P- G, v$ Z, ]/ Tcharacteristics of the stromal cell types, as well as of the% O" _# r1 K8 p6 J4 f0 O
extracellular matrix (hatched background), evolve during : D% R) m$ R1 ? a$ Oprogression, thereby enabling primary, invasive, and then. T t/ B% l& S
metastatic growth. The surrounding normal cells of the5 ~; ]4 B. N9 v
primary and metastatic sites, shown only schematically, ) `1 m& Z7 E$ x" J9 mlikely also affect the character of the various neoplastic( ^& F8 S) [# h+ L( J; o2 @& b( b
microenvironments. (Not shown are the premalignant$ u; ]+ z2 d5 m! F) r8 d
stages in tumorigenesis, which also have distinctive 0 T, G7 O8 |5 K8 c8 e2 N8 q6 e, Pmicroenvironments that are created by the abundance 4 r; r) G" `# A) O1 Iand characteristics of the assembled cells.)作者: embryonic12 时间: 2011-4-6 22:45