标题: <Cell Stem Cell> 2011.3 Perspective. A Precarious Balance Pluripotency Fac [打印本页] 作者: 清风闲云 时间: 2011-5-5 11:41 标题: <Cell Stem Cell> 2011.3 Perspective. A Precarious Balance Pluripotency Fac
Kyle M. Loh, and Bing Lim2 X3 W9 D( m4 E# F
Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of ( ~' p# G" W) A. D( jdevelopmental and translational consequence. We propose that pluripotency transcription factors are/ A* S0 N6 G2 H4 T5 U s
lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the ability to( ^5 F" U4 ^1 z0 V* W
differentiate into particular cell types, and concomitant expression of multiple lineage specifiers within pluripotent 0 V4 U: ]/ M6 z7 Gcells enables differentiation into every fetal lineage. Moreover, we speculate that, rather than being an ) u; x' g4 o0 x' c/ lintrinsically stable ‘‘ground state,’’ pluripotency is an inherently precarious condition in which rival lineage u, ^: s) f) m3 R7 Especifiers continually compete to specify differentiation along mutually exclusive lineages.! @; ]# q/ r/ ~" V5 ?( q- a+ d
[attach]26458[/attach]作者: webber43 时间: 2011-5-11 08:58
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