[attach]30007[/attach]Emerging models and paradigms for stem cell ageing / l$ H; y; ~ v/ }6 h9 H0 i. ?6 ~D. Leanne Jones and Thomas A. Rando * L5 }7 B% q% H+ J* s3 h8 Q: SAgeing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. 3 b& H S& x' H8 X, x/ yHere we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction3 i& \, T/ K- `
in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal & Z9 B5 C0 |# Z* aand aberrant differentiation potential. ' b( | m5 X, M9 |; E& B"Nature cell biology 13(5) 2011" 5 G: X' v4 g/ P# q* Z作者: liuer0041 时间: 2011-7-12 11:11