标题: 再来一本病毒学经典--Virology:principles and applications--John B. Carter [打印本页] 作者: dahui 时间: 2011-7-14 17:27 标题: 再来一本病毒学经典--Virology:principles and applications--John B. Carter
' r# F4 I$ h* K1 V% |Greek letters used in this book. 4 U) A1 l$ K1 K. Q- Z. ~4 o. ^: g; {) Y5 @; Z4 Z
Colour coding for molecules. 9 a- [. d3 V- A* D 7 Y+ y6 t6 g: C; X1 Viruses and their importance. & o! h8 h1 N' ~9 N5 n' z - |; G$ U. r8 \$ P8 R1.1 Viruses are ubiquitous on Earth. 7 b0 A2 X1 F8 n+ G5 }2 Q8 k% |; H( @+ U2 j
1.2 Reasons for studying viruses.. c5 U+ W' w! W5 t: D2 U' N
% n0 s. O' U+ B1.3 The nature of viruses.# l) z c% ]' a- q9 z
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1.4 The remainder of the book. & O' w) ~+ P; u9 C 8 O5 B2 Z- z* a8 y4 H2 Methods used in virology. : ^ y# Q3 ]5 K: i . e, O8 O7 D, w0 i' Z2.1 Introduction to methods used in virology.0 ?* o$ |. J. \2 O7 p1 F
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2.2 Cultivation of viruses. ; c' Y3 |: w! F( ~- e( I4 q& ?3 Y& k9 F# Y( n
2.3 Isolation of viruses.9 `: a' x [ W8 @- U: k
1 c7 V& V- _: U8 p2.4 Centrifugation.% E+ ^' Z- N! G* N# ~
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2.5 Structural investigations of cells and virions.2 V% s/ j9 B v$ W2 Z6 ^
: d1 J7 g$ a" |- E. _2.6 Electrophoretic techniques. 9 `7 P& o7 c) u9 ?# x2 o s8 {, ~1 Q* a# w8 e" ?( P% t7 y) s G
2.7 Detection of viruses and virus components. ) W) O! E% r& M # T5 I- M( Q4 u* I6 Z2.8 Infectivity assays.8 i4 w+ S) g8 e0 m
$ |; H; G2 G6 Y* k4 M2.9 Virus genetics. ! W3 p, J" I: ]8 |4 l2 P$ K9 D0 K, C P7 f1 V2 a) N/ ]- ?
3 Virus structure. 9 d* S P) s3 N! i+ k( b+ b. m& e+ H
3.1 Introduction to virus structure.+ h6 |$ |2 {) z y) g& g6 v3 F
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3.2 Virus genomes.& m# {9 I, _2 p- F3 k0 u* p8 Z% B
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3.3 Virus proteins.6 s ~7 u+ F$ U$ a4 W9 z% T H4 q" h
$ z8 f5 a8 ~5 H. a) U, ^; u3.4 Capsids. ; q6 i' p, A& `2 K2 b7 Y3 y' u3 t+ v% H+ E# A8 r
3.5 Virion membranes. 4 v8 w: L( g$ r' U, Y9 G" g$ t. O+ G: w5 d6 |. O
3.6 Occlusion bodies.% t+ Q* ?+ ?# ~9 [ i- Y
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3.7 Other virion components. 3 D, {9 F z+ [! \3 p" q# L8 |. w M Z/ s* F/ S. P8 J
4 Virus transmission.( A" e7 ?+ m, w- F \( k7 A
$ t& }% g# M+ e9 r4.1 Introduction to virus transmission.' x5 Q' I6 M$ ^' I
0 J' m( o+ \0 X2 E6 z) q5 n+ I* e4.2 Transmission of plant viruses.: D! m. w+ n2 X7 R3 B
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4.3 Transmission of vertebrate viruses. " }8 Z6 n1 l- ~1 ]; r: ^4 @ , h. p% Z5 ]# h# s. V/ c0 Q" w4.4 Transmission of invertebrate viruses.+ Y& ?0 v& k+ f& b0 r! ^
2 i# {5 I3 p: g+ f: g+ h* d/ T( d4.5 Permissive cells.0 Z* f( i& y# T3 }
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5 Attachment and entry of viruses into cells. - u/ d& j- w) E) |, N% X% y; h% \, c( n/ M& ~
5.1 Overview of virus replication. 3 \; ^* p$ V! u0 x* E% j# {6 N" g 0 ^8 X' l! x$ z5.2 Animal viruses.$ h2 I; v! y! q4 j! ]; m
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5.3 Bacteriophages.1 `1 [+ p5 Z$ p* i
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6 Transcription, translation and transport. ( ]) w: J- j% J" z5 S 4 ^! ^% w* O$ z+ {0 w2 o6.1 Introduction to transcription, translation and transport. ! {1 Z& y8 D8 f- V+ Q5 O( d1 U' M7 C( \9 c/ f# {, k, h+ @$ u9 E
6.2 Transcription of virus genomes., M$ Y2 q- b/ q6 i! w/ O
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6.3 Transcription in eukaryotes., T& s. f3 R: ~/ b
) G# E9 a- w3 l+ D6.4 Translation in eukaryotes. # U7 T" ?% ]# B9 B3 q! P+ j( _9 _ N' y
6.5 Transport in eukaryotic cells.3 `, \" P! h1 \' m
" h& C3 s3 U. V1 l* M2 \6.6 Transcription and translation in bacteria. 5 C$ i, @. b8 Q6 ^- Z5 v, F4 d `# I/ d% e4 Q7 ^% r1 [; l
7 Virus genome replication. 6 D- L; ?$ k- D* h0 a % g( L* v3 L0 d2 w$ q, q0 X7.1 Overview of virus genome replication.( g7 r8 N5 i: t! g1 g6 E1 w& l: y
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7.2 Locations of virus genome replication in eukaryotic cells.3 x8 e6 O9 h6 X0 n
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7.3 Initiation of genome replication. ' \+ m) {! B+ r, ~ ; O+ {7 d+ O$ f2 n" I& V3 `9 m7.4 Polymerases. $ J( F* C3 m8 L- V6 V: m+ N/ J) l( S7 f. G' H+ }$ d( H
7.5 DNA replication.1 U% X! s" R- K2 Y% P' G
- k) e; ~/ X3 d. [6 h7.6 Double-stranded RNA replication. + W/ K b, l, G" w3 `. A; t# r 7 h2 X2 A/ ^8 _7.7 Single-stranded RNA replication., I9 d! A. [# _5 k
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7.8 Reverse transcription. ) A+ W, q: q! C: ^ , U2 }1 s* n* u: o) ~8 Assembly and exit of virions from cells. / h' x+ i$ m. K. n O : f$ g; S4 Z0 `# L1 W6 S% `1 b. q8.1 Introduction to assembly and exit of virions from cells.( A y7 }1 x( j0 t' ?6 n% R# D
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8.2 Nucleocapsid assembly. 5 C6 {1 O) i: N0 Q! T% A2 F ) ]# b4 w4 f7 ~$ O8.3 Formation of virion membranes. , B& P9 ^; i/ {2 _: t' U. @ ! d4 j2 B3 y9 X6 ], ?1 |/ G8.4 Virion exit from the infected cell. : ?& j! t: n0 B9 e3 w; L; f" {5 f$ R! o1 n2 q
9 Outcomes of infection for the host.+ ]0 V3 O% C5 Y
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9.1 Introduction to outcomes of infection for the host.4 k/ {/ |5 p8 z8 F E
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9.2 Factors affecting outcomes of infection. 3 Q. w: j% Y. V/ N 8 ^; @5 K; k0 W0 d4 W. o; \9.3 Non-productive infections. ( W# W4 V+ O: G; }) c5 B 7 u0 |" ]+ K6 N6 Y7 _6 B9.4 Productive infections. 5 ]: g7 h" e, V6 `4 J# l# C$ x4 g0 Q! D0 v7 D8 w
10 Classification and nomenclature of viruses. 7 c& A2 I' K1 O2 n - o& u/ v$ c: P+ \* c9 `# i8 y10.1 History of virus classification and nomenclature. + |$ S" s: J) c8 ]% v& n 4 }8 f% ?) {* c4 R- z10.2 Modern virus classification and nomenclature.3 V/ ]: K# _+ E4 [) K$ R
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10.3 Baltimore classification of viruses.) O9 e) T1 L. y# } Z
7 T+ S4 O6 E6 D2 N; Y, D' } C11 Herpesviruses (and other dsDNA viruses). & H$ u: v8 }/ k7 l6 [ v% H1 v4 ?3 e) H% x; H
11.1 Introduction to herpesviruses. . X- T5 A( T5 I# m5 s9 n. D9 l% l' O0 w9 [+ ^
11.2 The human herpesviruses. : h# ~/ @+ E! X) h# J& Y, e1 i" O1 E
11.3 The herpesvirus virion.5 p# H" x% c9 J+ s& t
$ [* l7 {! X: C! ]11.4 HSV-1 genome organization. : s( z0 C; r- P7 [% D$ U! a8 b$ [& c- I
11.5 HSV-1 replication. : N2 U8 w2 D4 @; z) }/ q+ W. m* \# b9 M + }: g: y$ |; d7 Q2 D8 v3 W5 R11.6 Latent herpesvirus infection. 8 a) M4 V5 C3 s) f1 o5 }# ` 2 H4 D9 m3 [5 o, F8 G. }11.7 Other dsDNA viruses. 0 i- Y" w6 ~- ~, D9 [ & x7 D4 v; \# Z& L8 r2 b12 Parvoviruses (and other ssDNA viruses). ( F) U, }( x" H% Q0 \" }) D0 \7 b8 X' X4 ^
12.1 Introduction to parvoviruses.& ? o$ q/ g" {7 j6 m( k
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12.2 Examples of parvoviruses.* P2 t& s% L7 F& P8 W4 g
- D- s% j8 r$ M1 r12.3 Parvovirus virion. t x% ]% B) ~9 c1 c5 s
% ?; [' k6 @! w/ G, D( k* s3 f12.4 Parvovirus replication. . ?7 n) L$ N/ {2 |9 p6 c3 j% Z7 k( t% {; n. `: e9 j
12.5 Other ssDNA viruses. 4 D- Q, t3 b& W7 n- F: O; d6 {. K$ N2 }
13 Reoviruses (and other dsRNA viruses). / _6 }$ B9 v1 a# l8 S/ \; A/ \/ F5 E- p! e' O3 k! C2 l
13.1 Introduction to reoviruses. 7 s! `3 p, D+ {/ [ 0 M1 v9 A3 _0 x1 b; J13.2 Rotavirus virion. , n5 i- i& x0 D) ~* \) s' m2 Y % U6 @& r$ c/ _/ z' L( P13.3 Rotavirus replication.# T4 _' d1 q$ k! l
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13.4 Other dsRNA viruses.+ ?6 g4 g& [9 F# u
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14 Picornaviruses (and other plus-strand RNA viruses). / E1 x0 ^ W3 Z0 m# o2 z6 N$ H: h
14.1 Introduction to picornaviruses.1 S& S8 B4 O. G1 r1 v& _7 G# v( J) ^
2 w" A4 a; e( T6 i, Z14.2 Some important picornaviruses. 1 X; {7 C; L6 k; M0 M# ^; P- M8 C R" ~2 r$ {- m# I1 ^: N2 Q
14.3 The picornavirus virion.& K& u4 s- C2 C+ u R/ k$ h
) B! d6 {2 A7 i1 |14.4 Picornavirus replication. / o; P' P( H# [1 Y& \+ t5 A2 w3 k/ E7 i, x
14.5 Picornavirus recombination. & x, \: `* J9 D3 D2 a3 X7 }% P- S, `1 ] c. B5 b8 {
14.6 Picornavirus experimental systems5 Q5 \1 y/ Z8 X9 t3 ?: K, d: l. f$ }; K
2 F; b' o' M+ X1 v" w k' z14.7 Other plus-strand RNA viruses., i7 P7 {: h9 C- C. M
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15 Rhabdoviruses (and other minus-strand RNA viruses). 9 }' ]) Z2 q+ _5 l' C; z S ) T' y: P" ]7 }3 x0 J5 e1 f9 u15.1 Introduction to rhabdoviruses.. v$ ]# U6 A& W1 d( d
$ x6 f/ |+ G, [6 [15.2 Some important rhabdoviruses.' F8 x5 m, \8 k5 ^% D
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15.3 The rhabdovirus virion and genome organization. ' s' C. q; s5 w$ M% B$ j8 K& m8 C4 ]8 z
15.4 Rhabdovirus replication. . b. C' q5 Y1 @0 ?0 [8 p9 r1 L& L4 H9 G: @/ K5 ]
15.5 Other minus-strand RNA viruses. * { z: L" y. Q6 Q/ o* A9 m 0 p1 T4 O) u% \+ e15.6 Viruses with ambisense genomes. 6 Z3 U! {% k& y( C: {- j( P6 {2 h' W8 H6 P. V) S8 v
15.7 Reverse genetics.9 b' y. Y0 p$ |8 J+ G, V0 H: i
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16 Retroviruses. e; d3 u% Z7 x) Z3 h
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16.1 Introduction to retroviruses. ' u3 n6 ]4 w [- K. S; n 9 G/ \! f; F, }& a. J5 \0 m16.2 Retrovirus virion. . b! f( x1 D0 G* B& T3 O) U7 A ) C) P( X1 R* v2 t$ p# N16.3 Retrovirus replication. % f' u1 `6 K, l# W( k . C# C8 j4 H w. v( [; r8 H16.4 Examples of retroviruses.' Q" b0 ?, b6 s( U# t
8 V% g) p& Z. X# A17.1 Introduction to HIV.; M6 P0 Q# ]1 f# P Z- q+ z
- Z7 x5 L0 y& P: i. X* G" z7 O17.2 HIV virion./ l# F9 ~ |3 v2 K! N
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17.3 HIV genome.5 |5 A, q" O+ T$ U& v n8 m
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17.4 HIV-1 replication.( o/ v: I4 K F
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17.5 HIV-1 variability. : q/ n$ T" n" J' h: U. k* C+ s9 ~
17.6 Progression of HIV infection. : f0 b7 {5 V' _. b' ~1 h$ U4 d7 |+ z* S; i- n8 A. E) m. i) O& R
17.7 Prevention of HIV transmission.0 r+ x2 ?( c: I( R* \8 X! F
" j; V$ J, K3 q0 p$ y u18 Hepadnaviruses (and other reverse-transcribing DNA viruses).. G6 ~. A' B; M3 I( w. o) _5 G+ h
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18.1 Introduction to hepadnaviruses. ; ~6 }7 i7 M- g' z1 t 4 q1 X5 e, W) O18.2 Importance of HBV. & x: l; Y/ M( I1 q y: f" T; z + j8 U; L! H3 P: o4 W/ ~/ H* t18.3 HBV virion. ; X2 u$ t; k5 W4 }% f! Y6 I) A# B
18.4 Non-infectious particles.% h8 w9 S! q2 \
% |* Y& M) d' u+ E6 j9 f9 \8 h18.10 Other reverse-transcribing DNA viruses.2 j& U2 |" D& _7 B# i) l$ q7 {
1 y, k8 Z: k! |# {. c- i19 Bacterial viruses.& w& u C) d8 Z5 h7 r& w# P4 B# D
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19.1 Introduction to bacterial viruses (bacteriophages. ; l8 F5 V1 Y) e0 v; w: B, }% |0 Y- }: T* ]4 z( s
RNA PHAGES.4 N0 r' m7 }7 |. w7 H
+ r7 K2 j/ U' ]: K3 i1 u19.2 Single-stranded RNA phages.5 l( a M# ]% v+ R
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19.3 Double-stranded RNA phages.4 \, M! b, Z, i
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DNA PHAGES. 8 V/ D, M U; n6 X ( z `0 d( N/ a; O19.4 Single-stranded DNA phages.7 E+ S) C, y1 o I. i9 R
$ L$ M" K w& [7 l$ `4 l2 x' n x19.5 Double-stranded DNA phages.7 @2 l- O9 c# a4 X
$ B1 M; ^" ^' N8 d* E8 M. ~1 `5 n20 Origins and evolution of viruses.) |+ \( s4 `1 d
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21.1 Introduction to origins and evolution of viruses.. }! v9 g( F& _- D: g- y) z9 w
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20.2 Origins of viruses., p/ n( [1 U7 s3 p2 X H
9 n" v3 D4 J' `; n% K20.3 Evolution of viruses. . W3 S" W/ `/ h' E8 P" N& \* d w D5 R8 u# ?. t7 L5 f+ D9 R
21 Emerging viruses. , L5 w5 f* i) G: L, w1 z- B - _# @2 X( U5 _21.1 Introduction to emerging viruses# a, t) @" `9 f0 W* v5 n. C7 D
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21.2 Viruses in new host species 2 C( J, ~4 e& W! M4 z. z& x! g ' h' z2 r9 F2 M: H21.3 Viruses in new areas% u1 C5 E) `4 N
0 M6 I+ u) L) B2 f ]21.4 Viruses in new host species and in new areas' A4 q7 u1 k: K9 C+ i8 |
% B. j# I& f# B) W% d5 n) f, |21.5 New viruses$ K( G. h7 ]7 e6 c1 S/ e! I
% m( L- h& ~ b. W v21.6 Recently discovered virus 9 h# Z6 E5 w2 X$ \6 X2 ], Z4 I' v # F8 a: n4 \) I) e21.7 Re-emerging viruses u+ P4 B* \. Z" X# p }! h- H
* \- b& X+ g9 }% F. ^21.8 Virus surveillance % l! }: e7 z! f" q% [, E0 ]2 i9 x2 L* B8 v, \2 @4 w
21.9 Dealing with outbreaks3 D3 N& @2 P( y9 g, l
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22 Viruses and cancer % b( H5 f8 g1 ^3 T* {) K8 o$ p/ E( Z2 ?5 B
22.1 Introduction to viruses and cancer % g. z4 \2 i S- W2 Z* Q% U: b * h" [6 V' f; R% W9 b) a- n& q* R22.2 Papillomavirus-linked cancers 9 f$ n" a' K+ ]9 H9 d: Z) k! H) y' W
22.3 Polyomavirus-linked cancers; \/ I" N9 v) O' N
+ E. k5 B5 n! [- J7 p& C! y22.4 Epstein-Barr virus-linked cancers 2 N1 C3 i# Q' ?. u2 R$ o1 h 8 l+ _9 {2 p `3 h8 @8 q0 s# w22.5 Kaposi’s sarcoma ; S* p! G. O+ i% J, d4 ~0 ]" f 8 P% s* ^( Q8 W. b) E& _22.6 Adult T cell leukaemia 7 ]9 o) h& M: V+ ~" Z3 D # L( m5 s/ {0 D* Y$ r22.7 Hepatocellular carcinoma 5 Q, {; c: \6 n! Q3 I- D7 \) d; t: s0 E2 M- b* f
22.8 Virus-associated cancers in animals+ E8 q" u6 A; B! ?. t3 |2 t$ \
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22.9 Cell lines derived from virus-associated cancers.2 l9 C- m5 X% M5 `
4 Q9 b; m/ }0 N22.10 How do viruses cause cancer? T. C* Z: E: {6 z # A) K) ~# q! m8 I* ^6 {# N X22.11 Prevention of virus-induced cancers. ) x$ v/ b% L; H O* k* v " { J; c! X% K6 b23 Survival of infectivity. . x$ ?2 R! k; z1 p3 W ( e) X9 ] Q# O( q3 ?& E23.1 Preservation of virus infectivity. - F" t0 L# |' ^0 [. `, \8 [2 e5 n* w) f7 C
23.2 Destruction of virus infectivity.3 m0 W5 D& R/ I) |. x
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