在文献中看到这样一段话 In some tumors, normal tissue stem cells may serve as the cells-of-origin that undergo oncogenic transformation to yield CSCs; in others, partially differentiated transit-amplifying cells, also termed progenitor cells, may suffer the initial oncogenic transformation thereafter assuming more stem-like character. 0 }4 A# @' c5 ~! V ( F# v8 Z6 g# V0 T; ] 这里好像说Transit-amplifying cells 是祖细胞，在网上查了好久。! x4 J3 |6 u& a, V. f, b8 e; c0 g' k
有一篇文献《隐窝干细胞和结肠癌的发生》中说是“子代中有少量的传递- 放大细胞(transit-amplifying cell, TA)，TA细胞具有非常有限的分裂和自我更新能力，大约经过3 － 4 次分裂，通过一个位于隐窝中低部的传递-放大区域(transitamplifying zone)向上迁移，最后到达肠腔面。” ! k0 k$ a0 c9 T8 a& X+ R) F' J; Z 而另一篇文献《肠上皮干细胞分裂、分化的信号转导机制》中说“肠上皮干细胞的不对称分裂就是一个干细胞和一个子代细胞(daughter cel1)，其中干细胞可以维持自身数量的恒定，而子代细胞继续分化为“过渡扩增细胞”(transit．amplifying cell，TA)。TA可以认为是多能细胞，正常情况下不具有干细胞的特性，因为它们将继续朝着各个方向分化，最终分化为分泌性细胞(包括杯状细胞、潘氏细胞、内分泌细胞)和吸收细胞，最后走上凋亡的道路。但肠上皮干细胞受到损伤的情况下TA会向隐窝底部迁移．恢复成为肠上皮干细胞。 ; I* n! z, K4 l1 d) i6 @ $ h) X. x5 G. l( B 求正解！是否真是祖细胞？作者: grape 时间: 2011-8-25 07:54
本帖最后由 grape 于 2011-8-25 08:05 编辑 w# G. C1 t! C6 n' \& K, H+ k7 |
以下是"Adult stem and transit-amplifying cell location. Histol Histopathol. 2006 Sep;21(9):995-1027"一文对Transit-amplifying cells (TAC)的解释：4 d9 ^+ }8 `& E" c
Transit-amplifying cells (TAC) are committed progenitors among the Adult stem cells (ASC) and their terminally differentiated daughter cells.2 u$ j# O8 g4 c4 Z
“过渡-扩增细胞（Transit-amplifying cells,TAC）”被认为是介于成体干细胞（Adult stem cells, ASC) 与其终末分化子细胞（terminally differentiated daughter cells）之间的一类祖细胞（progenitors）（或前体细胞）。0 Z% V2 X7 C$ i' m5 e7 k) S
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个人认为该细胞被命名为"Transit-amplifying cells"正是取"过渡、介于"之意，the cell have a transitional amplifying ability." A; k6 k/ R* d( ^% T! T
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Histol Histopathol. 2006 Sep;21(9):995-1027. 3 D/ Y/ v: Q2 y$ k. w$ ]Adult stem and transit-amplifying cell location. 1 a' i1 h4 {: X/ l6 j' T4 uDíaz-Flores L Jr, Madrid JF, Gutiérrez R, Varela H, Valladares F, Alvarez-Argüelles H, Díaz-Flores L. 0 a4 Q v. S5 L0 H3 S8 ?9 oSourceDeparment of Pathology, Histology and Radiology, School of Medicine, La Laguna University, Canary Islands, Spain.3 ]6 t% C/ o. G- d; ~
2 V7 }# L+ |. |" o+ w- oAbstract; f1 A5 d2 F+ _' M
Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be useful to regenerative medicine and tissue engineering. The ASC reside in a specialized physical location named niche, which constitutes a three-dimensional microenviroment where ASC and TAC are protected and controlled in their self-renewing capacity and differentiation. The niche can be located near or far from the recruitment point, requiring a short or long-distance cellular migration, respectively. This paper briefly reviews the current status of research about ASC plasticity, transdifferentiation, fusion and functional adaptation mechanisms. Subsequently, ASC and TAC occurrence, characteristics and location have been considered in the skin, cornea, respiratory tract, teeth, gastrointestinal tract, liver, pancreas, salivary glands, kidney, breast, prostate, endometrium, mesenchyma, bone marrow, skeletal and cardiac muscle, nervous system and pituitary gland. Moreover, the role of cancer ASC has also been revised. $ W% e$ \6 q& [( j% ^8 X 0 Z" N1 H# O: z z" C( ]6 \PMID:16763950[PubMed - indexed for MEDLINE] 5 i* T4 m: W# L% H1 d ; r+ a) G, ], M# h' {% S' kAdult stem and transitamplifying cell location.pdf(2.9 MB)
Adult stem and transitamplifying cell location.pdf
(2.9 MB)