标题: 1998-nature-Dendritic cells and the control of immunity [打印本页] 作者: andylee824 时间: 2011-9-1 13:41 标题: 1998-nature-Dendritic cells and the control of immunity
B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic8 j7 L" q) e- c- ]( d) b
cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to ( _. z7 y/ Z/ [7 D5 R u) O; Mlymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also8 w% T! k3 I- ?( H7 u
tolerize Tcells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once 5 m6 M, J, c4 S1 R& I2 R wa neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell ' J) F4 W v4 W0 K4 q1 Kbiological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the : M9 \0 A7 W) B1 F5 X, W" Eimmune system.作者: andylee824 时间: 2011-9-1 13:44