In additional mating studies we have conducted (as yet unpublished)9 x6 d! ?$ T) O
using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous1 J: L& y: P: @- k* x2 n
breeding assay following heat shock. Results from these 6 r4 H8 A: V v; Qexperiments separate the histopathologic lesions in early 0 H0 z0 _0 P# ]and late spermatogenic stages (i.e., apoptotic spermatocytes), : P1 u- g. u+ D4 l. x5 h( {0 pwhich are dependent on HSF1 and inducible HSP $ p9 O; s/ `* B- zexpression, from longer-term effects on reproductive performance ?* e; r) U; L6 q0 A- o) v9 mrelating to spermatocyte-specific but stage-independent + h, ^; W3 P* @1 veffects. ! B" } p7 V" D& `6 v E) N6 Z( B来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression, ; f1 _# d9 h1 E5 o! x0 w; h& wand Fertility in Adult Male Mice。) O, z3 M0 f: A2 `; Q
236页删划线部分7 H( l [' C, z; M4 i W
# A* {/ L1 x, Q! L' f
谢谢哦。[attach]37089[/attach]作者: 随心 时间: 2011-12-22 11:28