标题: Human DNA Repair Genes [打印本页] 作者: sjmpt 时间: 2012-3-26 11:00 标题: Human DNA Repair Genes
本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑 7 t/ E& o' z6 e% S: o- \: ] E8 ]) Z1 ~
Cellular DNA is subjected to continual attack, both by reactive species inside# e7 G* N4 M3 a) C( K
cells and by environmental agents. Toxic and mutagenic consequences are, d5 s8 g" |2 J6 F9 Y
minimized by distinct pathways of repair, and 130 known human DNA repair * R/ h5 N! p; u0 a! j1 |genes are described here. Notable features presently include four enzymes that# s2 K6 @/ n- ~2 x
can remove uracil from DNA, seven recombination genes related to RAD51, and 9 p2 z* S5 o* w& j0 Pmany recently discovered DNA polymerases that bypass damage, but only one % Z$ {6 ^6 c+ E. P8 Msystem to remove the main DNA lesions induced by ultraviolet light. More% H* @" K3 }" |$ D& f
human DNA repair genes will be found by comparison with model organisms $ ? r4 @# e4 I1 cand as common folds in three-dimensional protein structures are determined. / d" t/ W5 i/ y8 L0 x' O0 U2 mModulation of DNA repair should lead to clinical applications including im-+ b2 z; p* \) [+ B7 p
provement of radiotherapy and treatment with anticancer drugs and an ad- % a' x! l) p; N g* bvanced understanding of the cellular aging process.# l8 X; @. x$ Z8 b/ h3 U