本帖最后由 nero1981 于 2012-3-29 13:25 编辑 / Z5 r& u% Q; u* j) P/ ? i ; e7 E6 P! W/ \& v, O5 C, R/ z+ \5 k5 r- [; e- F
Cancer cell lines are widely used as preclinical models to gain mechanistic and therapeutic insight. Two manuscripts in this issue describe the large-scale genetic and pharmacological characterization of human cancer cell lines. Each group characterized collections of several-hundred cell lines using different platforms and analytical methods. Their results are complementary, and confirm that many human cell lines capture the genomic diversity of their respective cancers. Initial findings include the identification of a number of potential markers of drug sensitivity and resistance. For example, Garnett et al. report an association between EWS–FLI1 gene translocations, frequently found in Ewing’s sarcoma, and sensitivity to PARP inhibitors, a class of drug currently in clinical trials for other cancer types. Barretina et al. report a possible association between SLFN11 expression and sensitivity to topoisomerase inhibitors. On the cover, dividing fibrosarcoma cells. Cover credit: Steve Gschmeissner/SPL/Corbis 6 P1 ]* n2 D# m0 ^5 V" G- G作者: wanggongyu 时间: 2012-3-29 15:19
作者: ophden 时间: 2012-3-29 15:54
为啥看不了,也下载不了附件啊。悲催了作者: zorro 时间: 2012-3-29 15:57
3qqq作者: lgclgc 时间: 2012-3-29 16:23
thank you very much作者: tpwang 时间: 2012-3-29 16:43
回复 nero1981 的帖子% m0 k! \& F3 H2 a; O) q
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thanks作者: linlicau 时间: 2012-3-29 18:33
good $ i& U \% V/ J; C" R+ ]( }5 B8 S作者: 懵懂干细胞 时间: 2012-3-29 19:25
谢谢分享作者: manybit 时间: 2012-3-29 19:36
看看作者: future007 时间: 2012-3-29 20:13
不错的东东作者: as85543849 时间: 2012-3-29 20:34
谢谢作者: jj2570782 时间: 2012-3-30 08:22
LZ辛苦了作者: piliayouxia 时间: 2012-3-30 09:29
这么快,围观作者: quanri1126 时间: 2012-3-30 10:02
辛苦* A5 _4 I1 h& T; }& W. P4 k0 U/ K3 ]. p 作者: eley 时间: 2012-3-30 10:12