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Volume 149, Issue 3 9 R8 j8 @; c$ b8 ]4 I1 {On the cover: The combined activity of neurons in the brain generates , d- b0 W4 T: d O& a5 zoscillatory rhythms, or “brain waves,” that can be detected by * ?' d2 _* X+ Y) x/ C$ `* m
electroencephalographic recordings. Verret et al. (pp.708–721) found that these " d9 L4 ~' D$ `. W9 W+ Vbrain waves, which are represented on the cover by an undulating pattern, are 6 T$ w, O( S6 ^, z' B% f7 [: yaltered in mouse model of Alzheimer's disease (AD), and the changes are linked % g! |/ w9 ~- j- v7 P c0 l
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring % z) D& q2 s, ]4 wNav1.1 levels specifically in inhibitory interneurons improves oscillatory 4 n" s% e/ O. O4 }( d9 s: A
rhythms and memory in AD mice, offering a new therapeutic approach for ( c6 i- ^4 Y7 [" Rpotentially treating cognitive disorders. The image was created by Arantxa ; V! Q5 G) p) B- [. e) e& I9 u! w
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop 3 o* f+ a$ K* J; |- b: d(electronic recreation). {' @ E# }6 h4 h1 \" f5 r 作者: menghy 时间: 2012-4-27 13:55
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，有下载完的大虾能不能给传一下shangtaott@126.com，谢谢了