# i$ G" E! [, ?" xIslets. 2012 Jul 1;4(4). [Epub ahead of print]/ W: j) P' Q9 u) k9 f
Mnx1: A gatekeeper of β cell fate. 5 M4 F9 x1 X- @' N1 m9 c, HDalgin G, Prince VE. 7 i3 W. g1 R/ KSourceDepartment of Organismal Biology and Anatomy; University of Chicago; Chicago, IL USA. i1 }% ~8 X9 R/ c7 @# K5 x
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Abstract + G0 i/ f0 f2 w8 r. Q$ J' vA full understanding of embryonic endocrine pancreas development will be key to the establishment of islet replacement strategies. In particular, it is important to identify molecular pathways that establish the correct balance of specific endocrine pancreatic islet cell types. Recently, our work in the zebrafish has revealed that the correct ratio of α and β cell fates depends on the homeodomain transcription factor Mnx1 (Hb9); in the absence of functional Mnx1, β cell precursors give rise to α cells. ( 1) Our study suggests that mnx1 may function in β cell precursors to suppress the α cell fate. Here we consider how Mnx1 may interact with other endocrine-specific transcription factors to specify β cells. Our work emphasizes the vital importance of Mnx1 for β cell development, and suggests that identifying Mnx1 transcriptional targets in β cell precursors may provide important new information of direct relevance to stem cell-based protocols to cure diabetes.; N+ u" \9 l* i6 S/ i' a& d 作者: enyacat 时间: 2012-9-4 11:41
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好的，谢谢哈~~作者: enyacat 时间: 2012-9-5 11:34
回复 flydayzhu 的帖子 , ~2 O" |) B) [. r8 K2 ?- n j, d. @
咦，你给我的威望加2又收回去了？作者: enyacat 时间: 2012-9-5 11:35
回复 flydayzhu 的帖子 ( L7 f, @2 B. O5 t8 w ' C6 A, r2 H( K( f2 B/ V页子上写着呢The pdf of this article is not yet available for download. Check back soon.作者: flydayzhu 时间: 2012-9-5 12:04
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那好像不是我操作的，可能是其他版主吧~~~作者: enyacat 时间: 2012-9-5 15:57