, w$ w2 v8 \3 d, J5 D. kGuo Huang及其同事在研究小鼠模型时发现，所谓的C/EBP转录因子激活了发育和损伤时的心外膜。阻断受伤心脏的心外膜中的C/EBP信号传导可减少炎症并改善心脏功能。 6 X9 @+ }9 C( V" a" x) i# P % Q5 y* C1 G' p+ Z3 T- Y6 I) h $ U. C. m- O3 ^! R( O0 U, P2 _5楼原文 感谢jianlindunev 提供作者: 坤明 时间: 2012-11-20 11:27
C/EBP Transcription Factors Mediate Epicardial Activation During Heart Development and Injury 5 M6 h: S# [0 @ 7 Y* h. F3 `# ^& |. T1 iGuo N. Huang, Jeffrey E. Thatcher, John McAnally, Yongli Kong, Xiaoxia Qi, Wei Tan, J. Michael DiMaio, James F. Amatruda, Robert D. Gerard, Joseph A. Hill, Rhonda Bassel-Duby, Eric N. Olson 9 i% f5 ?; r0 e |. l* |" T6 j& a9 r4 N1 G" U+ c9 ]9 q
The epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and repair. Injury of the adult heart results in reactivation of a developmental gene program in the epicardium, but the transcriptional basis of epicardial gene expression has not been delineated. We established a mouse embryonic heart organ culture and gene expression system that facilitated the identification of epicardial enhancers activated during heart development and injury. Epicardial activation of these enhancers depends on a combinatorial transcriptional code centered on CCAAT/enhancer binding protein (C/EBP) transcription factors. Disruption of C/EBP signaling in the adult epicardium reduced injury-induced neutrophil infiltration and improved cardiac function. These findings reveal a transcriptional basis for epicardial activation and heart injury, providing a platform for enhancing cardiac regeneration. % Q, T; P0 `; S, E$ e" `" U" v- t
. r& c8 C5 t7 d8 X 作者: 坤明 时间: 2012-11-20 11:27
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