本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑 9 c0 I* i5 Y0 J4 R3 s + U5 X% L* s6 \# q! p - `, n: Q) A9 S$ q/ K7 ~" qVolume 153, Issue 1 1 [! N3 o: `- Z; a: r! tOn the cover: The kind of food an organism consumes has a broad reaching 8 I1 Y* q N( U% K
impact on its development, behavior, and lifespan. In this issue, two 9 q A/ e6 O$ H
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore # f+ V4 _# V- R" `9 ?& ethe effects of diet on these life-history traits in the nematode C. 2 N$ c7 y @2 D3 N9 c) E
elegans. Combining nutrigenomics and network analyses, they find that & h- E- }# W* s7 \3 A) E. Qdifferent diets affect traits via distinct mechanisms. The response to diet is D% } a- Q% \# k8 ]9 ccoupled to metabolic changes, and disruptions of some of these specific 0 O: \5 y, J0 O9 c( g
metabolic pathways correspond to inborn errors of metabolism in humans. The . g+ d) t* W# k0 x7 q0 m8 W1 o
cover features a “native-art-inspired abstraction” of a worm eating a bacterial e3 x" M- G" y0 R. V& O5 D4 Qdiet and illustrates the interconnectedness between diet, nuclear gene / l4 ^1 c$ Y: F1 B
regulatory networks, mitochondrial networks, and their effects on life-history 5 l+ V9 [1 @. btraits such as development and brood size. Cover art by Lesley T. MacNeil.5 \/ o: F" M2 b0 V# U. M y& E! `6 f
