本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑 2 R6 p6 N5 V4 j, W* F: e4 m1 G 5 @6 o2 N7 R: e/ r' b- Y' h- s& E 2 i, ]5 y8 e, d, ^& f7 r% W3 A& zVolume 153, Issue 1 + u, G$ N% o+ B1 Z4 g% e: NOn the cover: The kind of food an organism consumes has a broad reaching , Q: l* c% g, x) O( Y8 e- q
impact on its development, behavior, and lifespan. In this issue, two $ g3 T$ ^( }) j+ D$ P# o3 e
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore # Z/ a7 F- o' E8 l+ N. ^5 r( ]the effects of diet on these life-history traits in the nematode C. 5 i5 |2 J3 |9 |: h
elegans. Combining nutrigenomics and network analyses, they find that / \# _" b- L; f- Q8 D+ X
different diets affect traits via distinct mechanisms. The response to diet is # e; C4 y! [4 @$ ^4 n
coupled to metabolic changes, and disruptions of some of these specific . n% t( Y& ^6 m+ [% K" c; m: M6 Vmetabolic pathways correspond to inborn errors of metabolism in humans. The 5 d' V7 t& X7 {
cover features a “native-art-inspired abstraction” of a worm eating a bacterial 3 n Z0 x* }9 k6 h. P/ r% f) m1 q
diet and illustrates the interconnectedness between diet, nuclear gene 0 b$ Z$ U- B9 @7 {" I/ Aregulatory networks, mitochondrial networks, and their effects on life-history 6 ^. r( P/ {3 z1 k; D
traits such as development and brood size. Cover art by Lesley T. MacNeil.# l3 R- B* I' N k8 a
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