本帖最后由 naturalkillerce 于 2013-5-4 11:00 编辑 . J) a4 ]' ~' b
* ?. Y# X% m7 X8 a 回复 naturalkillerce 的帖子 / K) T) i" B* iScientists reproduce epileptic pathology using iPS cells 0 U; Y$ W! y. ?A Japan-based group of scientists has successfully reproduced the pathology of a severe form of epilepsy by using induced pluripotent stem (iPS) cells derived from a patient's skin, bringing the global medical community a step closer to understanding the neurological condition and how to treat it.9 L# M( L1 H' \0 \5 o
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The research results were published on May 2 in Molecular Brain, a British scientific journal. 1 _/ n% O& F9 I' C0 ^! @6 m0 m# e7 Z3 |. x L1 Y Q/ d6 o
Epileptic seizures arise when a balance between excitation and inhibition is lost in nerve cells, resulting in proneness for excitation. ) D& t* j& c7 W( f ! \* R4 F" i: b |Epilepsy occurs in one in every 100 people, with 30 percent of the cases believed to be severe forms that cannot be fully controlled with drugs. 0 \6 K" K, Y5 ?: ?" @- r7 y9 Y6 E. T! c1 ^
The team of researchers from Fukuoka University, Keio University in Tokyo, and other institutions generated nerve cells from iPS cells, which were derived from the skin of a patient suffering from a severe form of epilepsy involving SCN1A gene malfunctions.$ Z8 g2 N! k5 K/ v' ^# S% y4 `
% ~6 s/ N7 g+ M7 w- o% M: RWhen compared with control nerve cells from iPS cells derived from an epilepsy-free individual, the nerve cells from the patient-derived iPS cells showed a decline in functions to inhibit brain activity, the apparent main driver of epileptic seizures.# ~5 O6 z$ [; y( w
' V9 W* y, T2 f8 r* T2 Y% |7 aThe use of patient-derived iPS cells to help clarify disease mechanisms and develop new drugs and therapies is drawing attention as a novel approach of research. iPS cells have so far been derived from patients of Alzheimer's disease, Parkinson's disease and other ailments.6 l }$ d. L4 D; w7 E9 O$ m2 E
. l) K. W/ ]4 H g* o0 M/ {& c! D- _/ x) I http://ajw.asahi.com/article/beh ... airs/AJ201305030047作者: naturalkillerce 时间: 2013-5-4 11:07
A human Dravet syndrome model from patient induced pluripotent stem cells 2 O/ o3 a3 X; [; ^8 {doi:10.1186/1756-6606-6-19 ' ~) P4 G+ R. s1 Whttp://www.molecularbrain.com/content/6/1/19/abstract L# k Y* D2 N& ?! q- g) n7 e1 p) H) [5 D& D' [( s; V/ J# t! r$ ~! `/ s
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