, X/ ~' _' S% r% G8 V ( g) ^+ K! \% W2 {Volume 25, Issue 3On the cover: & |6 C1 V, O3 |" F6 m- c2 [
Epidermal growth factor (EGF) induces fast and efficient mitotic progression, 1 R8 h3 m! R( H0 l& D# aparticularly in cancer cells, by accelerating centrosome separation. Thus, a ! a4 q0 [1 E4 ^" \9 C- Z" c2 j+ ?HeLa cell treated with EGF proceeds faster through mitosis (left path) than a , X" W \! k- r8 b: c; T, W, M: ^
cell left untreated (right path), as visualized by confocal microscopy. - n( e. o+ e0 V+ I6 F5 U& C. G7 n
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear : f/ J; T0 @* N, Kenvelope. For more information on the effect of EGF on centrosome separation and : W! G3 r) y: E. g( Hmitotic progress, and on how this may relate to cancer therapeutic strategies, * R- l6 P9 O4 C
see Mardin et al., pp. 229–240.1 o3 r& W8 @& | G1 F P
