4 N9 E' p% F$ O# b" k' t. x7 Y ' A& q1 w0 W- V' a. i9 j Volume 78, Issue 4On the cover: Neural networks control ; b4 \" }9 C. ~5 C- h5 p# iintrinsic encoding of the circadian clock. Circadian pacemaking in the 8 B2 @5 l! M7 ~, o
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 7 j2 b+ E5 R7 j* o: c: T
intercellular properties, with the latter still poorly understood. In this issue & r. ^ ]! L6 {) g& `$ t: b6 C
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level . n z% B/ a' n( ]; z, O5 @: Pencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in 7 d* N4 g! d% l, l5 T
restricted SCN neuronal subpopulations reprograms encoding of circadian time by 7 t, e* j1 L& S* U7 N
the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic , J6 j7 F9 |7 H+ a6 H$ nconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna ' e; D; u {* p8 u4 }0 Y9 p5 lWestmoreland. : V. F- t, A* X, \ 5 ~, o+ G9 M5 e$ B作者: tempo 时间: 2015-6-14 16:01
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