( f# S. u: Y5 u1 |: Z' M9 w( B ( J& `% ]9 g, ]1 b/ q' [0 N/ M: C! P Volume 78, Issue 4On the cover: Neural networks control % U; B P: S$ |" g% r. Lintrinsic encoding of the circadian clock. Circadian pacemaking in the 4 w* n) S1 _' L2 R2 X
suprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and 0 Y9 z3 ?/ |' G! Z3 n O* Tintercellular properties, with the latter still poorly understood. In this issue 8 {2 c5 p1 G) E; I* W! m3 G- m
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level 2 d& C3 Y2 z" Sencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in * P; E/ p- i3 t9 D
restricted SCN neuronal subpopulations reprograms encoding of circadian time by : k, u1 _: P1 h7 U! |the entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic , ^$ J8 u7 Z A. i8 t/ R$ c. C
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna 9 J5 c9 s5 v4 A; \& m* F: I* TWestmoreland.& [- s( v+ P1 x3 a( P' Z" |5 n