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Volume 38, Issue 5: T8 l3 w$ A+ ^
On the cover: Regulation of metabolic pathways in the immune system provides 6 Z) c" M+ j/ W/ ~- r Qa mechanism to actively control cellular function, growth, proliferation, and 6 A% |* v q3 ` a3 l9 U
survival. However, the contribution of microRNAs to the regulation of cellular ) }3 L+ c( I6 v5 t6 o
metabolism in the immune system is unclear. In this issue of Immunity, . D4 u% Y0 a$ h- {+ T: s" r. ^Henao-Mejia et al. (984–997) show that the miR-181 family is a critical 7 g6 \, z% f% Ddeterminant of cellular metabolism, and therefore it is essential to support the 7 ~0 e# h, _" Y2 ?
high biosynthetic demands of lymphocyte development. In particular, regulation , i Z: m/ a3 k
of cellular metabolic pathways by miR-181 is absolutely required for early % i* P( B' m" X: F+ @2 g5 [! |natural killer T cell development. The cover cartoon depicts a lymphocyte that & x6 I, u6 R9 o W! L& a) H3 Inecessitates the presence of miR-181 (represented as an electrical plug) to # n3 T' k c% Imaintain a robust metabolism. Thus, in the absence of miR-181 (unplugged 5 O- A* R+ M8 S
status), the lymphocyte lacks the energy to efficiently carry out normal * P$ m* b; H( q* Y
functions. Image created by Gustavo Zapata.( m( H, y3 l) R# a 作者: yuheng 时间: 2013-5-24 21:18
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