/ Y/ c# x0 Q; q L$ s5 C0 Z' kVolume 78, Issue 5 & v) o, B) x1 Q E m0 F) s2 D- e6 YOn the cover: During brain development, commissural axons cross the midline 2 Z- F( U9 W2 J6 k4 W
and later elaborate synapses in their target areas. Using a conditional Robo3 # b8 X7 E" m3 n, k" `* u- X- w- B
knockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868) ) A) L$ {, N3 [+ |8 d9 Z9 n
report that axon midline crossing conditions the functional maturation of this : M& K4 h# o( }
large commissural output synapse. In contrast to contralateral calyx of Held 4 z% I( x6 B0 f0 E$ s( @
synapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3 , J! O- T9 ~/ I! E% y. econditional knockout (cKO) mice showed strong deficits in synaptic transmission. $ D/ g' t# j) X. F2 [9 j
The aquarelle on the cover depicts the calyx of Held-generating axons and their 9 [% k! g/ C3 P* z: H" qsynapses as flowers. On top, the physiological situation is represented by " \6 H7 h B$ j, t# _1 d/ ]( ] v
crossing stems that lead to functional calyx synapses, symbolized by colorful & q1 |# m5 G* c4 P" gflowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by # F/ w7 s3 P! \; lstems unable to cross, leading to fading calyceal flowers. The aquarelle was F6 w& n: K" |
painted by Nicolas Michalski. ( b* |" v$ C1 C$ I C作者: cz200203 时间: 2013-6-21 11:48
