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Volume 78, Issue 5 / ~. P6 A$ Q; ^7 ]# {On the cover: During brain development, commissural axons cross the midline 3 R) i N0 ~. ^4 g1 g
and later elaborate synapses in their target areas. Using a conditional Robo3 $ j3 M; i) V' Z K5 Z
knockout approach at the calyx of Held synapse, Michalski et al. (pages 855–868) 5 X! i9 |8 [6 ]0 x
report that axon midline crossing conditions the functional maturation of this ( S9 N- A2 B% T$ t- e1 S4 F- ^large commissural output synapse. In contrast to contralateral calyx of Held 1 {3 d* b$ R$ D! E" U4 W" `8 esynapses in wild-type mice, ipsilateral calyx of Held synapses in Robo3 # g1 v1 d, T! ]9 L; P, }% Hconditional knockout (cKO) mice showed strong deficits in synaptic transmission. % ` D4 o0 c% q* G7 rThe aquarelle on the cover depicts the calyx of Held-generating axons and their 5 N: I3 h3 y4 p# r- Q' u) j$ W
synapses as flowers. On top, the physiological situation is represented by 6 H' t- s/ @7 s5 G. F% V* z9 Fcrossing stems that lead to functional calyx synapses, symbolized by colorful - c* j0 c9 R7 lflowers. Below, nonfunctional calyx synapses in Robo3 cKO mice are depicted by : U" P) S' M2 _- F, {
stems unable to cross, leading to fading calyceal flowers. The aquarelle was & |' K5 J0 ^5 a; P7 H
painted by Nicolas Michalski. 6 Q1 j5 t0 y$ t* a( U& q# A作者: cz200203 时间: 2013-6-21 11:48
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