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Volume 21, Issue 61 b S2 d6 p8 y9 f/ H+ R$ B. U
On the cover: The modeling of protein structures in the complete absence of + P9 T" }- c) U k% {' ]any sequential similarity to any known three dimensional structure remains a 0 l! ~5 l( c" d$ w3 `0 S achallenging problem. Recently, it has been shown that proteins are built from a 2 K7 Z, @- ~& s' flimited set of possible supersecondary structural motifs (Smotif). Menon et al. 3 t/ g" Z6 S+ V(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical # C8 @& o9 ~3 P" e- i
shift information of loop segments is used to guide the selection of entire : K1 U7 L! [/ \Smotifs for any given target sequence. The selected Smotifs then assemble into 2 T" A2 Z0 h5 Z! ?0 D3 O" @three dimensional topology. Although the approach usees only backbone fragments }- `7 `' W t5 a
of Smotifs without any sequence information and limited experimental . d6 |7 q& O3 i( ^/ n
information, it is successfully capturing the correct topologies of almost all 9 \8 E" P4 d* H1 l% d4 X
tested targets. The cover image was created by Mario Pujato, graduate student at 2 f m V* f( @4 z' m: a8 Ythe Albert Einstein College of Medicine, Bronx, New York. 2 V0 [$ U- B2 f$ U% C作者: xiaomao_zhoubo 时间: 2013-6-10 23:14
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