Science. 1982 Oct 15;218(4569):297-8.) i5 ~0 M) a5 u2 D5 j
An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: possible hormone receptor system.% m( H& H; H5 l* ^# K6 E
Feldman D, Do Y, Burshell A, Stathis P, Loose DS. ' o+ l0 y6 u7 t( v& S6 UAbstract 4 U$ \1 B( f7 s9 c$ |A protein macromolecule in the cytosol of the unicellular eukaryotic yeast Saccharomyces cerevisiae selectively binds the vertebrate estrogen hormone 17 beta-estradiol with high affinity. Lipid extracts of the yeast cells or the conditioned growth medium yield a substance that can bind competitively to the tritiated estradiol-binding sites in the yeast and to mammalian estrogen receptors. These findings suggest that the binding protein may be a primitive hormone receptor and that the lipid-extractable substance represents the endogenous ligand. 0 Q E+ c) j$ }+ g! \PMID: 6289434 [PubMed - indexed for MEDLINE] & }4 t# O$ P+ c6 o, [ , d% w: }1 ?; J! _% P" h8 i网址：http://www.sciencemag.org/content/218/4569/297.long作者: michael1013 时间: 2013-8-12 19:34
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