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标题: Cell子刊:发现免疫细胞能促进肿瘤干细胞存活 [打印本页]

作者: naturalkillerce    时间: 2013-9-10 09:42     标题: Cell子刊:发现免疫细胞能促进肿瘤干细胞存活

本帖最后由 naturalkillerce 于 2013-9-10 11:20 编辑
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Cell子刊:发现免疫细胞能促进肿瘤干细胞存活
9 f+ T3 _: x' C1 @6 l" S时间:2013-09-09 09:12:41 来源:生物无忧 作者:davidtower ( L  U# |; I% r$ S

  l( x. v+ `9 M  G        众所周知,免疫系统通常保护身体免患疾病。但是一小部分免疫细胞似乎是弊大于利。; m# n9 Y+ I5 Y! ]5 n
        在一项新的研究中,来自美国密歇根大学综合癌症中心的研究人员发现这些被称作髓系来源抑制性细胞(myeloid derived suppressor cells, MDSCs)的免疫细胞提供一种让肿瘤干细胞(cancer stem cells)存活的微环境(niche)。相关研究结果于2013年9月5日发表在Immunity期刊上,论文标题为“Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2”。! v% U0 z4 g0 c( Y1 [
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        肿瘤干细胞被认为对当前的化疗和放疗产生抵抗力。研究人员认为杀死肿瘤干细胞是根治癌症的关键。
" f1 b: ?/ W% L6 V! Y- D! @        这些MDSCs不仅有助癌症,而且它们也抑制免疫系统。论文通信作者Weiping Zou博士说,“这种细胞和它的作用机制对人体是不好的。它们通过让肿瘤干细胞茁壮成长而有助癌症。如果我们能够鉴定出一种靶向这种机制的疗法,那么我们就能够解除免疫抑制和对肿瘤干细胞的支持。本质上就是,我们希望一石二鸟。”
0 t/ I8 K0 f# V        研究人员认为这些MDSCs让癌细胞具有干性(stemness)而使得它们变得致命性,而且如果没有这种免疫细胞,那么这些肿瘤干细胞可能不会高效地导致病变。/ c5 C0 U6 I5 a& E* V, s% y6 z0 J
        在这项研究中,论文第一作者Tracy X. Cui博士、论文通信作者Weiping Zou博士和同事们研究了来自一种最为常见的和最为致命性的卵巢癌的细胞,其中患上这种癌症的病人经常对化疗产生抵抗力,而导致癌症复发。( p: f1 _! b8 W& O
        用于癌症治疗的免疫疗法作为一种具有很大治疗潜力的方法当前正在很多癌症中进行临床试验。这些发现有助人们开发出这样的一种免疫疗法。
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本文版权归生物无忧所有,侵权必究。转载时请务必注明来源为生物无忧和保留原作者名。 0 @' J; g4 J/ o  A$ \8 J- R& }5 X/ }
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参照阅读:/ o8 ]  ?; Z$ o- I" r
    Some immune cells appear to aid cancer cell growth, study finds! P: |- T& Q4 i, n. c  p
原始论文:
3 w4 d. p( T# [6 n/ B4 f   Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2, Immunity, DOI:10.1016/j.immuni.2013.08.025

作者: helong    时间: 2013-9-10 10:51

生物无忧这篇简报,水平低!
5 m; L* @$ N6 E/ b免疫细胞能促进肿瘤干细胞存活?应该是
( c1 q% \. f9 B- h" ZMDSC通过......促进肿瘤细胞干性
作者: naturalkillerce    时间: 2013-9-10 11:00

回复 helong 的帖子8 A8 [% E5 j! F9 I/ u( ]

* u0 [+ v2 n: Y# v  i( W" v这不是一种促进存活的机制么?
作者: naturalkillerce    时间: 2013-9-10 11:19

回复 helong 的帖子
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) w" }, v8 b8 Z0 j: y髓系来源抑制性细胞(MDSC)也属于免疫细胞。
作者: helong    时间: 2013-9-10 12:49

1MDSC本来就与血管生成相关;2MDSC本来就促进肿瘤;3(抑制性)免疫细胞促进肿瘤太寻常;% P0 e7 |2 Q* r  L& |( f" T
文章的价值在于找到了MDSC促进肿瘤的新机制和MDSC调节干性!
作者: naturalkillerce    时间: 2013-9-10 14:51

回复 helong 的帖子- T3 M0 O; n1 f6 H; K1 h

+ B. v; V2 W0 Z/ S) [8 q# j' ]这就是它为什么能发Cell子刊Immunity,即揭示其机制。
作者: naturalkillerce    时间: 2013-9-10 16:39

本帖最后由 naturalkillerce 于 2013-9-10 16:39 编辑   S; ~/ v* B" r& P; j  s
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回复 helong 的帖子6 B8 x9 m1 e6 b$ \. ]$ L3 ^
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提供这篇翻译译文的原始来源。好坏大家去判断。
" ?1 y- @, g1 jSome Immune Cells Appear to Aid Cancer Cell Growth
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Sep. 5, 2013 — The immune system is normally known for protecting the body from illness. But a subset of immune cells appear to be doing more harm than good.
: \% [# D% v; m5 @8 c/ OA new study from researchers at the University of Michigan Comprehensive Cancer Center found that these cells, called myeloid derived suppressor cells, provide a niche where the cancer stem cells survive.
7 ^) `; b/ L/ U( Q. ZCancer stem cells are thought to be resistant to current chemotherapy and radiation treatments, and researchers believe that killing the cancer stem cells is crucial for eliminating cancer.2 {+ U; @4 ]: r" Q
At the same time that these immune cells help the cancer, they also are suppressing the immune system.* A  a& @# M- I3 {
"This cell and its mechanisms are not good for your body and it helps the cancer by allowing the stem cells to thrive. If we can identify a therapy that targets this, we take away the immune suppression and the support for cancer stem cells. Essentially, we kill two birds with one stone," says senior study author Weiping Zou, M.D., Ph.D., Charles B. de Nancrede Professor of surgery, immunology and biology at the University of Michigan Medical School.. f3 @- g; u: A9 ]4 {& Z& _; {
The researchers believe the immune cells give the cancer cells their "stemness" -- those properties that allow the cells to be so lethal -- and that without this immune cell, the cancer stem cells may not efficiently progress.2 y& {6 G, l9 z/ x
The study, which was led by Tracy X. Cui, Ph.D., and Ilona Kryczek, Ph.D., looked at cells from the most common and lethal type of ovarian cancer, a disease in which patients often become resistant to chemotherapy, causing the cancer to return.* G1 v4 x8 d( Z( g' s8 R0 C
Targeting the immune system for cancer treatment, called immunotherapy, has been well-received with many potential therapeutics currently being tested in clinical trials for a variety of cancer types. The U-M team is a worldwide leader in the field of tumor immunology.% z2 U+ g9 s0 X
Additional authors: Other contributors are Lili Zhao, Ende Zhao, Rork Kuick, Michael H. Roh, Linda Vatan, Wojciech Szeliga, Yujun Mao, Dafydd G. Thomas, Max S. Wicha, Kathleen Cho, Thomas Giordano, and J. Rebecca Liu, all from the University of Michigan; and Jan Kotarski and Rafal Tarkowski from Medical University in Lublin, Poland.* `2 J* C5 ]4 z! J* u: m& J
Ovarian cancer statistics: 22,240 Americans will be diagnosed with ovarian cancer this year and 14,030 will die from the disease, according to the American Cancer Society' T3 h% i6 R5 U0 h4 f5 h# }0 m1 k
Funding: National Institutes of Health National Cancer Institute grants CA123088, CA099985, CA156685, CA171306 and 5P30-CA46592; the Ovarian Cancer Research Fund, and the Marsha Rivkin Center for Ovarian Cancer Research.
3 H+ b1 z, E1 J% w* T9 zhttp://www.sciencedaily.com/releases/2013/09/130905133752.htm




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