本帖最后由 Damon-Salvatore 于 2013-12-30 17:17 编辑 5 M: e, D. D5 D; H+ M! Z ( `! }' D: S( e$ M楼主在收集资料，对于已经诱导为iPSC的细胞有 成纤维 胃上皮细胞、肝细胞、胰岛β细胞、淋巴细胞、神经祖细胞 角化细胞等。这些已经找到了相应的文献。7 U1 H$ o. W i0 C# n U
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胃上皮 （Aoi, et al., 2008）肝细胞（Aoi, et al., 2008） 6 U3 n" C+ [* X0 _' n5 XAoi T, Yae K, Nakagawa M, et al. 2008. Generation of pluripotent stem cells from adult mouse liver and stomach cells[J]. Science, 321(5889): 699-702.* L! P7 R! A9 }2 W. Y, ]
3 j$ o& {" X: O j2 F$ ^7 @, c) p胰腺beta细胞（Stadtfeld et al., 2008） ) h: L9 ~" g2 Q7 L* M( e* D1 @6 Y8 CStadtfeld M, Brennand K, and Hochedlinger K. (2008). Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Current Biology 18(12): 890–894." C# d% p: J* R& f
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淋巴细胞（Hanna, et al., 2008） & j4 m6 D! |. v i. x5 U; V$ Z7 e. WHanna J, Markoulaki S, Schorderet P, et al. (2008). Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 133(2): 250–264.3 |7 ]# S- \: e4 |% x
+ m3 [5 f* l6 `4 a# [. D神经祖细胞（Eminli, et al., 2008）7 x# v! E8 Y! R n, q
Eminli S, Utikal J S, Arnold K, et al. (2008). Reprogramming of Neural Progenitor Cells into iPS Cells in the Absence of Exogenous Sox2 Expression. Stem Cells 26(10): 2467–2474. % b( d, n* z! E. A, ] * q( S! `) t9 J, p) }6 k角化细胞（Maherali et al., 2008）" d7 r6 @, v3 [3 \+ ^3 s" C9 N
Maherali N, Ahfeldt T, Rigamonti A, et al. (2008). A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell stem cell, 3(3): 340-345.& k1 {- z" P! f# w% _
& ~3 h( Z0 E6 b; ~3 u; q - f' M9 T2 a9 ~0 s" ^/ a 4 h$ _1 |+ _% K7 J. U' y 4 [8 C% a. Y, p3 ~' c7 J) r对于 肠上皮细胞 肌细胞和肾上腺细胞的相关文献实在没找到，还请大家指点一下。+ E3 G1 c! X6 K% g' z
另外，组蛋白脱乙酰化和DNA去甲基化抑制剂对iPSC诱导效率有影响，也请指点一下相关文献。 m0 n5 R3 W9 i: {& @+ J( ]' C
先谢谢了！作者: Andyhigh 时间: 2013-12-30 18:19