7 O, F& P0 u& @9 L) a* ]2014年4月24日 Nature 9 Y1 Y. f5 V, ?: v; @) I( |# {% F! }0 I4 i) z. I' }& ^
Mammalian Y chromosomes, known for their roles in sex determination and male fertility, often contain repetitive sequences that make them harder to assemble than the rest of the genome. To counter this problem Henrik Kaessmann and colleagues have developed a new transcript assembly approach based on male-specific RNA/genomic sequencing data to explore Y evolution across 15 species representing all major mammalian lineages. They find evidence for two independent sex chromosome originations in mammals and one in birds. Their analysis of the Y/W gene repertoires suggests that although some genes evolved novel functions in sex determination/spermatogenesis as a result of temporal/spatial expression changes, most Y genes probably persisted, at least initially, as a result of dosage constraints. In a parallel study, Daniel Bellott and colleagues reconstructed the evolution of the Y chromosome, using a comprehensive comparative analysis of the genomic sequence of X–Y gene pairs from seven placental mammals and one marsupial. They conclude that evolution streamlined the gene content of the human Y chromosome through selection to maintain the ancestral dosage of homologous X–Y gene pairs that regulate gene expression throughout the body. They propose that these genes make the Y chromosome essential for male viability and contribute to differences between the sexes in health and disease. Cover: Daren Newman 9 g7 ]+ W. N* J8 J; d' ^3 u6 b7 X作者: 千细胞 时间: 2014-4-29 08:38
楼主辛苦作者: CoolCell 时间: 2014-4-29 09:52
看看: J1 B- P) M. z3 p5 e5 w 作者: sysuhoo 时间: 2014-4-29 10:15
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多谢分享！作者: redmaple 时间: 2014-4-29 19:23
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你所在的用户组无法下载或查看附件？？作者: QRoc 时间: 2014-5-1 18:57
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总是很及时！作者: tiramisu 时间: 2014-5-4 09:37
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thank作者: zorro 时间: 2014-5-5 14:58
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take a look作者: xiaojiang9945 时间: 2014-5-14 19:22
能下载吗？作者: anthappy 时间: 2014-5-16 20:59
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感谢感谢作者: 风起云涌龙 时间: 2014-12-15 13:12
谢谢楼主！！！！！！！！！！！！！！作者: anew101 时间: 2015-1-14 19:54
god bless me the link still works now作者: biobio 时间: 2015-5-22 08:54
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