标题: 'Stem cells show promise in stroke recovery' [打印本页] 作者: usa 时间: 2014-8-9 13:08 标题: 'Stem cells show promise in stroke recovery'
http://www.bbc.com/news/health-28694656 / m1 G5 ?1 i4 M'Stem cells show promise in stroke recovery': p) u: G) r# ~
By Smitha Mundasad: y( t$ I, f+ |: U/ R
Health reporter, BBC News 2 w; H3 d& B6 q. S1 B9 q% B7 t2 e x M8 H* k. M8 K' U% l; J5 \
Researchers studied the most common types of strokes, caused by blood clots in the brain q& H/ g2 \) O' T
Continue reading the main story ) v: |% I3 [0 {Related Stories : F7 l7 p3 y: z, J, I( K) V " b) i5 g) x5 |3 M( yStroke stem-cell trial shows promise 7 c7 J5 V+ x# V, PInfusing stem cells into the brain may help boost recovery after a stroke, according to a pilot study by Imperial College London.1 _- p- T4 D8 c3 ?$ m
4 S" b% g# [% i; a7 |" U. PScientists believe the cells encourage new blood vessels to grow in damaged areas of the brain.* |: u: p+ j* f9 U
" \0 s+ O+ U6 G2 B2 |They found most patients were able to walk and look after themselves independently by the end of the trial, despite having suffered severe strokes., \! h g j+ D3 o5 x$ p$ T/ ~- G
' U r/ F1 u3 \7 e6 xLarger studies are needed to evaluate whether this could be used more widely.1 ^1 F+ U: O* z3 w& p: H% F4 o7 w, G
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Continue reading the main story; H' f+ M; h/ \! X# l( B& a
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Now we need to look at a larger group of patients and hope eventually to develop a treatment based on this approach” 1 S: x1 @+ V- z1 g$ C/ Z8 n! R 6 w3 b; Q& q9 ^- k) N. @: V8 }4 K, fDr Soma Banerjee 4 m- |( \+ V3 K) e R5 [" w4 y. PImperial College London - M4 L5 w: @2 W \In this early trial - designed primarily to look at the safety of this approach - researchers harvested stem cells from the bone marrow of five people who had recently had a stroke.# S: `- t% V5 n
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They isolated particular types of stem cells - known as CD34+. These have the ability to stimulate the growth of new blood vessels.$ d1 x, A$ B' Y8 t
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They were infused directly into damaged sections of the brain, via the major artery that supplies this area.4 a1 @6 ~/ o! o0 f
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Scientists monitored the patients for six months, charting their ability to carry out everyday activities independently. 6 J7 @- W( S; c8 C5 ~5 o' Z# Y0 P3 f) X% {( s, }) i
Four of the five patients had suffered particularly severe strokes - resulting in the loss of speech and marked paralysis down one side of the body.0 \- P6 Y; \4 q- O
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This type of stroke usually has a high fatality and disability rate. 7 ^5 O/ k+ d) D6 @% q$ A0 s, G/ X G& [+ l4 Q% J* e
But researchers found three of the four patients were able to walk and look after themselves independently at the end of the six-month period.. @2 i+ S+ j) C3 \
8 G7 n1 E; M4 c- DAnd with some help, all five were mobile and could take part in everyday tasks.( O" |' v% l5 v: x
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Though other stem cell treatment has shown promise as stroke therapy before, this is the first UK study to investigate using this type of approach in the first week after a stroke. 9 }5 d2 B! h! R; q! m9 a `3 w S9 P8 |- G3 O3 l+ x
Scientists hope getting to patients early will improve chances of success. 8 I* l& p3 C% ^+ o- q$ i; X1 n, d+ d. T7 Z) B6 `" U G* {
Dr Soma Banerjee, who led the study, told the BBC: "This is encouraging and exciting early research.* t4 x. m" G# [- e
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"Now we need to look at a larger group of patients and hope eventually to develop a treatment based on this approach." # C: K, e; ^ \( |; m8 j! `, K; R9 |/ u& k" o; M; Y
But Dr Tim Chico, from the University of Sheffield, who was not involved in the study, said: "It is important to understand this is only the very earliest step towards a possible new treatment for stroke and does not prove the stem cell treatment improved these patients' recovery. 3 J' ~( @# Q% A- p; c 9 {5 A3 R9 S9 S# {' G. S2 y) w C"A much larger trial will be needed to compare stem cell treatment with no stem cell treatment. 5 z' @$ X$ E: q. {3 r; m1 w # g7 b4 l: A' \6 H"Anyone who has seen the suffering a stroke can cause will be encouraged that doctors and scientists are continually exploring new ways to treat this devastating disease." + l; e4 w: Z* h9 C , E- K9 {, I2 P$ c* Q* j9 iThe study is published in Stem Cell Translational Medicine.