2014年9月19日 Science8 V: ^2 ?. T) ^, U, t! q5 g+ N - }" G: k7 d/ M' O
COVER Artist's impression of how a bacterial immune complex, called Cascade (foreground structure), from the CRISPR-Cas system recognizes invading DNA (red-blue-black strand) from a bacteriophage. Cascade, a complex of 11 proteins and a guide RNA, uses the sequence of the guide RNA to detect invading DNA. See pages 1452, 1473, and 1479 for a close-up look at Cascade before and after it binds to its target DNA.Illustration: Valerie Altounian/Science; protein coordinate data supplied by Scott Bailey. q$ I& C8 {- R& ^" L# E) K, J0 T
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