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标题:
Stem cell-based approaches to solving the problem of tissue supply for islet tra
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作者:
bobo
时间:
2009-3-25 09:24
标题:
Stem cell-based approaches to solving the problem of tissue supply for islet tra
Cale N. Street a, Simonetta Sipione b, Lisa Helmsa, Tanya Binette a,
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Ray V. Rajotte a, R. Chris Bleackley b, Gregory S. Korbutt a,∗
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a Surgical-Medical Research Institute, University of Alberta, Room 1074, Dentistry/Pharmacy Building, Edmonton, Alta., Canada T6G 2N8
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b Department of Biochemistry, University of Alberta, 4-60 Medical-Sciences Building, Edmonton, Alta., Canada T6G 2S7
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Received 13 August 2003; accepted 16 September 2003
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Abstract
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Type 1 diabetes is a debilitating condition, affecting millionsworldwide, that is characterized by the autoimmune destruction
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of insulin-producing pancreatic islets of Langerhans. Although exogenous insulin administration has traditionally been the
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mode of treatment for this disease, recent advancements in the transplantation of donor-derived insulin-producing cells have
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provided new hope for a cure. However, in order for islet transplantation to become a widely used technique, an alternative
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source of cells must be identified to supplement the limited supply currently available from cadaveric donor organs. Stem
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cells represent a promising solution to this problem, and current research is being aimed at the creation of islet-endocrine
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tissue from these undifferentiated cells. This review presents a summary of the research to date involving stem cells and cell
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replacement therapy for type 1 diabetes. The potential for the differentiation of embryonic stem (ES) cells to islet phenotype
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is discussed, as well as the possibility of identifying and exploiting a pancreatic progenitor/stem cell from the adult pancreas.
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The possibility of creating new islets from adult stem cells derived from other tissues, or directly form other terminally
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differentiated cell types is also addressed. Finally, a model for the isolation and maturation of islets from the neonatal porcine
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pancreas is discussed as evidence for the existence of an islet precursor cell in the pancreas.
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© 2003 Elsevier Ltd. All rights reserved.
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Keywords: Stem cells; Type 1 diabetes; Islet transplantation; Differentiation; Xenotransplantation
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时间:
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时间:
2009-8-16 19:02
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时间:
2009-11-15 00:56
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2010-3-23 14:33
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附件: abbr_e77589653cec1ef09b7b03844154e9f9.pdf (2009-3-25 09:24, 309.01 KB) / 下载次数 16