标题: Cell Cycle Control of Embryonic Stem Cells [打印本页] 作者: lizhen 时间: 2009-4-20 11:50 标题: Cell Cycle Control of Embryonic Stem Cells
Josephine White1 and Stephen Dalton*,2 5 {$ w6 X% @8 @( O/ t+ |1Department of Molecular Biosciences, University of Adelaide, South Australia, 5005; and 2Department , R# A6 y5 A7 M+ q) H+ b1 cof Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602 % v+ J3 K/ k6 b6 l. b& u0 g& E+ W( ~0 j
Abstract 0 H4 c- p% e- J( ?4 |: a4 UEmbryonic stem cells have the capacity for unlimited proliferation while retaining their: \( Q& q1 E$ f3 g) m6 D4 I
potential to differentiate into a wide variety of cell types. Murine, primate and human 6 R& Q0 s) |( f" o, V1 Wembryonic stem cells (ESCs) exhibit a very unusual cell cycle structure, characterized 6 u* B. _$ x! w9 o8 a$ Mby a short G1 phase and a high proportion of cells in S-phase. In the case of mESCs, this ; z6 C9 r- x! j& n6 m( ^2 }, ois associated with a unique mechanism of cell cycle regulation, underpinned by the precocious + L5 F$ s; v% `8 Pactivity of cyclin dependent protein kinase (Cdk) activities. As ES cells differentiate, $ E; B: |- U& c6 R% m5 f2 P. ktheir cell cycle structure changes dramatically so as to incorporate a significantly ( I' X5 W( u4 V( j$ d. A' Qlonger G1 phase and their mechanism of cell cycle regulation changes to that typically! @: c9 X8 a7 V$ [) a, G! K
seen in other mammalian cells. The unique cell cycle structure and mechanism of cell# p* |9 w" v9 _$ D
cycle control indicates that the cell cycle machinery plays a role in establishment or 5 O" S# P8 S/ [+ P1 Cmaintenance of the stem cell state. This idea is supported by the frequent involvement . X2 Q! G4 r3 ?$ C& [) _of cell cycle regulatory molecules in cell immortalization.. H. ]+ T( t6 K* m! ^$ V1 Z+ [
Index Entries: ES cells; cell cycle; Cdk; pluripotent. 7 @7 W, g( I9 \( p: C( Q& { 2 Y7 _' V( I8 A2 SCell cycle control of embryonic stem cells.pdf(268.19 KB)
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Cell cycle control of embryonic stem cells.pdf
(268.19 KB)